Chinese University of Hong Kong

The double-decking method for rezūm water vapor therapy in benign prostatic hyperplasia: volumetric, functional, and dosimetric outcomes

Abstract Background Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) significantly impact quality of life in aging men. Conventional Rezūm water vapor therapy consistently achieves only a modest 25–30% prostate volume reduction, leaving a clinic...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires fr...

Multi-objective and cross-scale inverse design of temperature-control materials via physics-constrained machine learning

Abstract Temperature-control materials, notably composite phase-change materials (CPCMs), show great potential for the thermal management of next-generation power electronics. However, the synergistic optimization of multiple performance metrics still relies heavily on Edisonian...

Prospective observational study of the impact of early-life feeding on gut microbiome development in caesarean-delivered infants: associations with clinician-confirmed illness

Caesarean section (C-section) born infants acquire a compromised gut microbiome at birth. This prospective observational study investigated the impact of early-life feeding on gut microbiome of C-section born infants and its association with clinician-confirmed, parent-reported i...

Impacts of droughts on biomass burning emissions, air quality, and public health in the Amazon

Abstract. Wildfires in the Amazon, increasingly influenced by climate variability and anthropogenic activities, pose severe environmental and health challenges. While drought events amplify fire activity and emissions, the cascading effects of droughts and deforestation on air qu...

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomo...

The information content of private information acquisition: evidence from FOIA requests to the SEC

Abstract This study examines whether Freedom of Information Act (FOIA) requests to the Securities and Exchange Commission convey value-relevant information about publicly traded firms and whether sophisticated investors trade on that information. Our empirical analysis reveals he...

Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses

Cardiovascular disease (CVD) is the leading cause of death and imposes a substantial burden on women’s health. Early onset of menopause, as a unique trait of reproductive aging, has been associated with a higher risk of adverse cardiovascular events in traditional observational s...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

Chitosan Microspheres Incorporating Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a Potential Multifunctional Platform for Postoperative Osteosarcoma Management

Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...

Neuropeptide diversity and evolutionary patterns in crustaceans: insights into adaptations, agonism, and functional importance in organs

<title>Abstract</title> Background Crustaceans exhibit great diversity in anatomical, physiological, and behavioral adaptations, all of which contribute to their evolutionary success, and neuropeptides are important regulators mediating these adaptations. While expansion of certa...

Single-leg squat knee biomechanics at 4 months post-operation predicts 6- and 12-month outcomes after anterior cruciate ligament reconstruction: a cohort study

Persistent functional deficits frequently complicate recovery following anterior cruciate ligament reconstruction (ACLR). This prospective cohort study investigated whether sagittal-plane knee biomechanics during a single-leg squat at 4 months post-ACLR predict functional outcome...

Engineering Hidden Ferroelectric‐Like Distortion for Ultralow Thermal Conductivity in Polar van der Waals Tetradymite

ABSTRACT Ferroelectric‐like polar structures enable diverse functionalities through coupling with charge and phonon transport. Although effective in modulating thermal conductivity, the rational design of novel polar materials with intrinsically low thermal conductivity via ferro...

Competition mechanisms of interfacial crack propagations in thermal barrier coatings

Abstract Cracking failure of thermal barrier coatings (TBCs) in advanced gas turbines under bending loads presents a persistent engineering challenge, particularly regarding how cracks compete and propagate through multilayer structures. This study addresses that challenge by con...

RKHS-Based Latent Position Random Graph Correlation

We study the problem of evaluating the correlation between two latent position random graphs, which is a challenging issue because the latent positions are generally unobservable in random graphs. We introduce a correlation coefficient that is defined in the reproducing kernel Hi...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications

Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-tissue studies provide important mechanistic evidence, but species differences a...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

Tribenzotriquinacene Fused Dimers (“Fusodimers”)—Synthesis and Host–Guest Properties

ABSTRACT The synthesis and structural properties of two stereoisomeric tribenzotriquinacene (TBTQ) derivatives, syn ‐ 4 and anti ‐ 4 , in which two rigid TBTQ bowls share a common benzene ring, are described. Owing to the orthogonal orientation of the three indane wings in each o...