Chinese University of Hong Kong

siRNA-mediated mismatch repair disruption synergizes with oxaliplatin to restore immune surveillance in microsatellite-stable colorectal cancer

Proficient mismatch repair/microsatellite-stable colorectal cancer (pMMR/MSS CRC), which represents the majority of clinical cases, exhibits low tumor mutational burden and minimal responsiveness to immune checkpoint blockade. Disrupting the MMR system has been shown to resensiti...

Effectiveness of 222 nm far-UVC disinfection of airborne and surface bioaerosols in railway trains

Abstract Since urban residents heavily rely on rail transit on a daily basis, controlling airborne infectious disease transmission in railway trains is critical for public health. In recent years, 222 nm far-ultraviolet C (UVC) lamps have emerged as a promising solution for disin...

State entrepreneurialism under economic transition: Bounded rationality in China’s high-speed rail new town governance

Drawing on 16 high-speed rail (HSR) new towns along the Beijing–Shanghai corridor, this paper develops a middle-range explanation of how state entrepreneurialism is practiced and differentiated under conditions of economic transition in China. While the notion of state entreprene...

Embedding e-learning in postgraduate medical education: system-level barriers and enablers in Hong Kong

INTRODUCTION: E-learning is increasingly central to postgraduate medical education (PGME), yet system-level barriers may hinder its integration. In Hong Kong, the Academy of Medicine (HKAM) has invested in a learning management system and faculty development, but uptake among Aca...

Enhanced Antibiotics Sieving by Exfoliated TiS2 Membranes via Surface Functionalization and Passivation

Abstract Transition metal dichalcogenide (TMD) nanolaminate membranes hold great promise for molecular sieving due to their two-dimensional capillary structures, which facilitate size-restricted diffusion. However, many transition metal sulfides exhibit intrinsic instability and...

ARport: an augmented reality system for markerless image-guided port placement in robotic surgery

Abstract Purpose Precise port placement is a critical step in robot-assisted surgery, where port configuration influences both visual access to the operative field and instrument maneuverability. To bridge the gap between preoperative planning and intraoperative execution, we pre...

Rapid general electromagnetic analysis of metallic surfaces via conformal energy minimization

We recently found that the electromagnetic scattering problem can be solved efficiently using an approach that expresses the fields in terms of a set of orthonormal basis functions. In this paper, we apply computational conformal geometry with the conformal energy minimization (C...

Integrated Analyses of mRNA and microRNA Regulatory Networks at Different Soil Moisture in Tropical Earthworm Eudrilus eugeniae

Earthworms play crucial roles in soil fertility and are vital to sustainable agriculture and environmental stability. Synchronously, they are highly sensitive to their environment, which limits their abundance and activities. Existing research primarily focuses on their protein-c...

Incidence and Risk Factors for Progression of Pachychoroid Subtype

Importance The incidence and determinants of progression across the pachychoroid subtype remain incompletely characterized, limiting risk stratification and follow-up strategies. Objective To evaluate progression, diagnostic transitions, and associated risk factors in eyes with p...

Asymmetry of inter-joint coordination patterns and variability between dominant and non-dominant legs during landing in young healthy adults: a cross-sectional study

Abstract Background Landing movement usually challenges motor control and causes lower limb injuries. Although asymmetries in landing biomechanics between the dominant and the non-dominant sides have been observed, the side-to-side differences in inter-joint coordination patterns...

Comparative Efficacy Of Different Computer-Aided Detection Products in Colonoscopy: A Network Meta-Analysis Of Randomized Controlled Trials.

Background and aims: Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of differ...

From Reactive to Proactive: World‑Model Enhanced VLA for Mobile Manipulation

Mobile robot manipulation demands tight coordination of locomotion and dexterous arm control under changing viewpoints and contacts, making the action space far larger than in fixed-base settings. Vision-Language-Action (VLA) models map perceptual and linguistic inputs directly t...

Existence and Uniqueness Theorem of Continuous and Monotone Bayesian Nash Equilibrium and Stability Analysis

Since the seminal work by Meirowitz [Meirowitz A (2003) On the existence of equilibria to Bayesian games with non-finite type and action spaces. Econom. Lett. 78(2):213–218], there has been growing attention to the existence and uniqueness of continuous Bayesian Nash equilibria....

Validation of the 15-item Things You Do Questionnaire among South Asian adults: a psychometric analysis

Abstract Background The Things You Do Questionnaire–15 item version (TYDQ‑15) is a brief self‑report measure assessing adaptive daily behaviours associated with mental health across five behavioural domains. Although the TYDQ‑15 has demonstrated strong psychometric properties in...

Dike‐Induced Earthquakes as Probes of the Local Stress Field Prior to the 1998 Eruption of the Piton de la Fournaise Volcano, La Réunion

Abstract Volcano‐tectonic (VT) earthquakes generated during dike propagation provide useful constraints on stress changes in volcanic systems. During the 1998 pre‐eruptive unrest at Piton de la Fournaise, ∼600 VT earthquakes were recorded. Using manually picked first‐motion polar...

Cost utility analysis of two BK polyomavirus screening strategies: quantitative polymerase chain reaction vs 2-stage approach

Screening for BK polyomavirus (BKPyV) with quantitative polymerase chain reaction (qPCR) or a 2-stage approach with urine cytology followed by qPCR are acceptable strategies. However, the magnitude of the health benefits and incremental cost of adopting these 2 screening strategi...

“Good Me” and “Bad Me” Function in the Relationship Between Child Neglect and Adolescents’ Social Networking Addiction

This two-wave longitudinal research aims to investigate the temporal relationship of child neglect on adolescents’ social networking addiction through the mediating mechanism of inferiority and the moderating effect of self-compassion and left-behind status. A total of 629 Chines...

The Political Economy of the Chinese Contemporary Art Market: Institutions, Value, and Global Circulation

This doctoral research examines the political economy of the Chinese contemporary art market, with particular attention to the institutional processes through which artistic and economic value are produced. Situated at the intersection of economic sociology, political economy, an...

从国家主导重组到技术能力形成：中国中央国有企业的组织机制、组态路径与创新结果

State-led restructuring is widely used to concentrate strategic assets, reduce duplication, and accelerate technological upgrading, yet a formal merger changes organizational boundaries more quickly than it creates technological capability. This thesis explains how and under what...

Industry-University cooperation in China's HSR Innovation

This doctoral research proposal investigates how China's Government–Industry–University (GIU) innovation system operates in the high-speed rail (HSR) sector, and what accounts for variation in its functioning and performance. Beginning from China's remarkable trajectory—from impo...