Charles University

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinic...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

Hidden in the clay. Unveiling the tradition of handmade pottery in Roman Thrace through an integrated analytical approach

Abstract Handmade pottery is among the most enduring yet least understood ceramic traditions of Roman Thrace. Long regarded as a simple household craft and primarily interpreted as a marker of local “Thracian” identity, it has rarely been examined as a dynamic cultural practice....

Maternal microchimerism: foreign friend, hidden enemy

Maternal microchimerism (MMc) encompasses the transfer and long-term persistence of maternal cells within the offspring-beginning in utero via the placenta and continuing after birth through breastfeeding. Once viewed as an immunological oddity, MMc is now recognized as a dynamic...

Cannabinoids modulate inflammatory tone and attenuate inflammatory responses in human placental explants

Abstract Background With increasing cannabis use during pregnancy, understanding how cannabinoids affect placental immune function is fundamental. The placenta maintains a regulated immune environment through innate immune pathways, including nuclear factor kappa B (NF-κB)–depend...

Preprint of "Cobalt Oxidation State Controls Ir–CoOₓ Catalysts for Acidic Oxygen Evolution: From Model Surfaces to PEM Water Electrolyzers"

Water electrolysis is a key technology for sustainable hydrogen production, yet its efficiency in proton exchange membrane (PEM) electrolyzers is limited by the sluggish oxygen evolution reaction (OER) and the high cost of iridium-based catalysts. Combining Ir with Co and its oxi...

Preprint of "Cobalt Oxidation State Controls Ir–CoOₓ Catalysts for Acidic Oxygen Evolution: From Model Surfaces to PEM Water Electrolyzers"

Water electrolysis is a key technology for sustainable hydrogen production, yet its efficiency in proton exchange membrane (PEM) electrolyzers is limited by the sluggish oxygen evolution reaction (OER) and the high cost of iridium-based catalysts. Combining Ir with Co and its oxi...

Differential responses of fungal guilds to climatic effects mediated by changes in dominant vegetation

Summary Climate is a major driver of fungal species distributions and community composition, yet disentangling the effects of climate‐mediated changes in dominant vegetation from other climatic effects remains a key challenge. To separate climatic effects mediated by dominant veg...

Cumulative Disadvantage of Judicial Harshness: The Effect of Previous Harsh Sentences at Sentencing

Sentencing disparities are often conceptualized as a static problem in which one judge imposes a harsher sentence than another would impose in the same or a similar case. However, less is known about the impact of sentencing disparities on subsequent sentencing decisions. We argu...

The Effect of Nitrogen and Phosphorus Fertilization on Plant Community Along Chronosequences of Reclaimed and Unreclaimed Postmining Soils After Coal Mining

ABSTRACT Nitrogen and phosphorus availability drive plant community composition, productivity, and ecosystem functioning. During succession, nutrient availability typically changes as organic matter accumulates in the soil, influencing both nitrogen and phosphorus pools. We asses...

Snow microinvertebrates from lowlands, high mountains and the Arctic—implications for conservation efforts

Abstract The protection of cryospheric ecosystems and their biota cannot be properly defined without a detailed species inventory. Snow microinvertebrates are crucial for estimating cryophilic biodiversity, yet they are poorly described at broader spatial scales. To fill this kno...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Biparental care is a resilient evolutionarily strategy persisting across multiple species of small carpenter bees despite low paternity

Abstract Biparental care is rare in insects and is commonly attributed to genetic monogamy, which yields high fitness benefits for caring males. The discovery of biparental care despite low male paternity in the bee Ceratina nigrolabiata challenges this view. We tested whether th...

Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes

Abstract Signalling via the epidermal growth factor receptor (EGFR) is indispensable for morphogenesis and tissue homeostasis. It is activated by extracellular ligands, typically released from transmembrane precursors by proteolysis. Ligand shedding activity is provided by the co...

Minimal Surfaces via Complex Quaternions

Abstract. Minimal surfaces play a fundamental role in differential geometry, with applications spanning physics, materials science, and geometric design. In this paper, we explore a novel quaternionic representation of minimal surfaces, drawing an analogy with the well-establishe...

Different Conditions, Different Composition: Reactive Environment-Induced Surface Composition Dynamics in Pt-Based Bimetallic Alloys

Abstract Due to their unique properties, bimetallic platinum-based alloys often exhibit superior activity compared to their parent counterparts for many catalytic reactions. Nevertheless, as multimetallic systems, they often undergo compositional and structural changes under reac...

Phylogeography of European hedgehogs revisited: Pleistocene northern refugia and ecological differentiation

Abstract Background This study re-evaluates the Pleistocene history of the European hedgehog ( Erinaceus europaeus ) and the Northern white-breasted hedgehog ( E. roumanicus ), by integrating genetically verified occurrence records, complementary allopatric GBIF records and ecolo...

Typology of transit-oriented development to promote sustainable urban structure

<title>Abstract</title> Transit-Oriented Development (TOD) has emerged as a transformative strategy in sustainable urban planning, aiming to integrate land use and public transportation to foster compact, walkable, and mixed-use communities centered around high-capacity transit s...

Impact of adpkd-associated PKD1 gene variants on the human facial phenotype quantified by 3d geometric morphometry

Verification and visualization of the possible impact of PKD1 causative variants associated with autosomal dominant polycystic kidney disease (ADPKD) on facial phenotype using three-dimensional (3D) geometric morphometry. Three-dimensional facial scans of 39 adult patients with A...

Hepatitis A vaccination and its public-health impact in routine prevention and outbreak control: a systematic review and meta-analysis

Background Hepatitis A vaccination is used for routine prevention and outbreak control, but its effectiveness and population-level impact have not been comprehensively synthesised. We aimed to assess vaccine effectiveness, certainty of evidence, and population-level impact. Metho...