Charles University

Cerebral Small Vessel Disease and Sleep-Disordered Breathing in Patients with Acute Intracerebral Haemorrhage: A Prospective Two-Centre Observational Study

Abstract Background Intracerebral haemorrhage (ICH) is the second most common stroke subtype and carries high mortality and disability. Cerebral small vessel disease (cSVD) and sleep-disordered breathing (SDB) are mechanistically linked and both implicated in ICH pathogenesis, ye...

Superconductivity in epitaxial PtSb(0001) thin films

Building on earlier reports of superconductivity in bulk PtSb, we present a systematic study of superconductivity in epitaxial PtSb(0001) thin films grown on SrF 2 ( 111 ) . Electrical transport measurements reveal a superconducting transition at T c = 1.72 K . The field-induced...

Self-reported aggressiveness does not follow facial masculinization in diverse South Asian populations

Abstract It has been suggested that sexually dimorphic facial traits are related to competitive behavior and aggression, but empirical evidence remains inconsistent and is based on a small number of populations and culturally homogeneous samples. We have combined geometric morpho...

Classical BV cohomology of the N = 1 spinning particle

A bstract We show that the classical Batalin-Vilkovisky cohomology at negative ghost number of the spinning particle, observed in ref. [1], is removed by a Koszul-Tate resolution involving saturation of Grassmann odd variables. The model thus satisfies the axioms of Felder and Ka...

Hemorrhage Volume and Imaging Recommendations: Factors for Decision Making in the Care of Patients With Perimesencephalic Subarachnoid Hemorrhage

BACKGROUND AND OBJECTIVES: Perimesencephalic subarachnoid hemorrhage (pmSAH) has a markedly better prognosis than aneurysmal subarachnoid hemorrhage. Despite advances in noninvasive imaging, the role of repeat digital subtraction angiography (DSA) after negative initial high-qual...

Programmable hydrodynamics of active particles

Abstract Self-propelled microparticles create flow fields that determine how they interact with surfaces, external flows, and each other. These flow fields fall into distinct classes–pushers, pullers, and neutral swimmers–each exhibiting fundamentally different collective behavio...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Fast Flexible LSQR with a Hybrid Variant for Efficient Large-Scale Regularization

Abstract. A wide range of applications necessitates solving large-scale ill-posed problems contaminated by noise, which are commonly formulated as linear approximation problems (possibly overdetermined or underdetermined). Krylov subspace regularization methods are particularly a...

Search for axion like particles produced via the Primakoff process at COMPASS

Abstract Axion-like particles (ALPs) are well-motivated candidates for dark matter and potential mediators to the dark sector. We present a search for ALPs coupled to photons, based on a reinterpretation of COMPASS data. Using the 2009 dataset consisting of $$190~\text {GeV}$$ 19...

VEGFA gene expression levels in patients with Parkinson’s disease and first-degree relatives

Abstract Background: Vascular endothelial growth factor A (VEGFA) contributes to angiogenesis and exerts neurotrophic and neuroprotective effects. Altered VEGFA expression has been implicated in neurodegenerative processes, including Parkinson´s disease (PD), yet findings from pe...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinic...

The development and psychometric evaluation of the brief Compulsive Pornography Use Scale (CPUS-4)

Abstract Online pornography use has increased worldwide in recent decades, with problematic use being associated with negative mental health outcomes. However, no brief instrument is currently available to specifically assess Problematic Pornography Use (PPU) by operationalizing...

Male Sexual and Reproductive Health in Diabetes and Obesity Pharmacotherapy: A Source‐Triangulated Counseling Map

BACKGROUND: Drugs used for diabetes and obesity increasingly shape male sexual and reproductive counseling, but clinical studies, trial registrations, regulatory labels, and patents answer different questions. OBJECTIVES: The objective is to map these sources and define what each...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

Hidden in the clay. Unveiling the tradition of handmade pottery in Roman Thrace through an integrated analytical approach

Abstract Handmade pottery is among the most enduring yet least understood ceramic traditions of Roman Thrace. Long regarded as a simple household craft and primarily interpreted as a marker of local “Thracian” identity, it has rarely been examined as a dynamic cultural practice....

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

Cannabinoids modulate inflammatory tone and attenuate inflammatory responses in human placental explants

Abstract Background With increasing cannabis use during pregnancy, understanding how cannabinoids affect placental immune function is fundamental. The placenta maintains a regulated immune environment through innate immune pathways, including nuclear factor kappa B (NF-κB)–depend...