Charles University

Hydrophobic MFI‐Type Zeolites via Alkali‐Cation‐Induced Defect Healing: Implications for Adsorbent and Catalyst Design

ABSTRACT Here, we demonstrate that sub‐stoichiometric amounts of alkali cations (Na + and K + ) critically govern defect formation during the synthesis of Silicalite‐1 (MFI), enabling precise control over framework integrity and surface properties after calcination. Combining sys...

Depression in people with epilepsy: reliability and validity of the Czech version of Beck Depression Inventory (BDI-II) and Beck Depression Fast Screen (BDI-FS) for major depressive episode

Objective Depression affects up to 55% of people with epilepsy (PWE) yet remains systematically underdiagnosed. This study aimed to evaluate the psychometric properties of the Czech versions of the Beck Depression Inventory–II (BDI-II) and Beck Depression Inventory–Fast Screen (B...

Common pathways and outliers in glucose catabolism across Trypanosomatidae

Glucose catabolism in trypanosomatids differs significantly from that in most other eukaryotes. Here, the first few enzymes of the pathway are all located inside glycosomes, that is, the peroxisome‐like microbodies uniquely present in the Kinetoplastida and Diplonemida of the Eug...

Outside Back Cover: Cycloazulenylene

Cycloazulenylene exhibits a remarkably narrow HOMO–LUMO gap, intense absorption in the visible range, and a unique tubular packing in the solid state. In Research Article e2204400, Tomáš Slanina, Oliver Dumele, and co-workers strained the nonalternant azulene, known for its anti-...

The Search for Life Elsewhere: Avoiding Hype and Fostering Public Understanding

The search for life beyond Earth presents unique challenges for science communication due to its interdisciplinary nature, the potential for groundbreaking discoveries, and the inherent uncertainties involved. The Lorentz Center workshop Breaking News: We Found Extraterrestrial L...

Temperature, pH and silica as key drivers of papillae formation in Mallomonas (Chrysophyceae) across local and continental scales

Abstract Papillae are small siliceous protuberances occurring on the scales and cysts of many chrysophyte algae, yet the environmental factors shaping their distribution remain poorly understood. We combined pan-European and local datasets to identify the key drivers of papillae...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation combined with antidepressants in major depressive disorder: a randomized, double-blind, single-center, sham-controlled trial

Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation (DMPFC-rTMS) has shown some evidence of an antidepressant effect. This study aimed to examine the efficacy and safety of DMPFC-rTMS as a combination strategy with concurrently initiated selective serotonin...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

Medium-term prediction of clinically relevant outcomes in first-episode schizophrenia patients

Background Predicting long-term outcomes in first-episode schizophrenia (FES) remains difficult, despite being especially important early in the illness, when timely intervention is most critical. It also remains unclear how much data from the initial phase of illness is required...

Soil enzyme dynamics under PFAS contamination in arid and Mediterranean soils

Abstract Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants increasingly detected in agricultural soils, yet their effects on extracellular enzyme activities remain poorly resolved. This study examined the short- and long-term effects of perfluorooctanoic acid...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Detailed study of non-equilibrium characteristics of quasi-neutral TNSA plasmas

In an experiment performed in November 2022 at the petawatt (PW) laser facility at Vega III located in Salamanca-Spain, we have studied the successful production of several radioisotopes using protons accelerated by the Target Normal Sheath Acceleration (TNSA) mechanism (Rodrigue...

The Impact of Robotization on Employees' Mental and Physical Health: A Qualitative Study in the Czech and Slovak Republics

BACKGROUND: This study aimed to explore the impact of introducing robotic technologies on employees' mental and physical health across three Czech and one Slovak manufacturing company. It sought to understand employees' subjective experiences and perceptions of organizational sup...

Timing pattern of Common Cuckoo parasitism and its relation to host nest attendance

Classical works show the adaptive importance of precise timing of egg‐laying in brood parasitic Common Cuckoos Cuculus canorus to ensure sufficient incubation time and successful hatching. Laying in the late afternoon has been suggested to increase the chance of secretive parasit...

From 5Cs to ABC: operationalizing the AAP guidelines into the MEPA-ABC scale for parental mediation of children’s digital media use

Parental regulation of children’s digital media use is central to healthy development, yet existing instruments are often lengthy or only loosely aligned with contemporary clinical frameworks. The American Academy of Pediatrics (AAP) formulated the 5Cs of Media Use (Child, Conten...

A high-resolution perspective on climate drivers of lake stratification and phototrophic community dynamics in Late Glacial Central Europe

Abstract. Predicting the trajectory of aquatic deoxygenation under global warming requires a mechanistic understanding of lacustrine responses to rapid climate shifts. We investigated how climate-driven changes in catchment vegetation and local iron-rich lithology regulated lake...