Charles University

Optimal Depolarization Sequence for CRT Patients

Abstract Background Electrical ventricular dyssynchrony is a hallmark of intraventricular conduction disease in heart failure with reduced ejection fraction. Although cardiac resynchronization therapy (CRT) is effective, a proportion of patients with ECG evidenced electrical dyss...

Foundational Fracture: Failing to Reform the World Trade Organization in an Age of Geopolitics

ABSTRACT The World Trade Organization (WTO) is at the crossroads, with a principal challenge raised to the organization by the United States in 2025 and a series of related, largely unsuccessful reform attempts over the last several years. To shed new light on why recent WTO refo...

Health utilities in individuals with alpha-1 antitrypsin deficiency with and without COPD from the EARCO registry

Background Data on health utilities in Alpha-1 antitrypsin deficiency (AATD) are scarce. This study aimed to evaluate health-related quality of life (HRQoL) using the EQ-5D in a cohort of AATD Pi*ZZ individuals from the European AATD Research Collaboration (EARCO) registry and to...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Polynomial Definability in Constraint Languages with Few Subpowers

Abstract. A first-order formula is called primitive positive (pp) if it uses only existential quantifiers and conjunctions. Primitive positive formulas are a central concept in (fixed-template) constraint satisfaction, as [Formula: see text] can be viewed as the problem of decidi...

Benchmark-Driven Selection of AI Can Improve Capabilities of Reasoning Language Models in Epistemology

Abstract Evaluation of reasoning language models gained importance after it was observed that they can combine their existing capabilities into novel traces of intermediate steps before task completion and that the traces can sometimes help them to generalize better than past mod...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Enabling climate action: A nexus approach for delivering co-benefits across biodiversity, water, food, and health

Climate response options rarely affect biodiversity, water, food, and health in uniform ways. This comparative analysis examines why technically viable response options generate uneven cross-nexus outcomes, and how governance and justice conditions shape whether these outcomes be...

Peritumoral B cells in primary colorectal cancer and synchronous liver metastases associate with longer survival

Abstract Purpose Prognostic value of local B cells across nontumor colon mucosa (NM), primary colorectal cancer (pCRC), and its paired synchronous and metachronous liver metastases (LM) are currently under investigation. This retrospective, single-center, hypothesis-generating st...

Prolonged low-dose intravenous thrombolysis in early recurrent stroke

INTRODUCTION: Treatment of acute ischemic stroke follows well-established guidelines and standards of care. However, the optimal management of ultra-early stroke recurrence remains unclear. We present outcomes of prolonged low-dose intravenous thrombolysis used as rescue therapy...

The ‘MIXPAR’ project

Abstract This paper presents an overview of a project aimed at creating and developing an extensive database of mixed perfective auxiliation systems. The project, named MIXPAR (MIXed PARadigms), compiles comprehensive data on mixed paradigms attested across a wide range of Italo-...

Judd-Ofelt analysis of holmium-doped alumino-silicate optical glass prepared by MCVD combined with nanoparticle doping

We present a detailed Judd-Ofelt (JO) analysis of Ho3+-doped alumino-silicate optical fiber preforms in a wide range of compositions and prepared by both standard solution doping method as well as the more advanced nanoparticle doping. The absorption spectra were measured, the ab...

Preprint of "Beyond Steady-State Limitations of Electrochemical Impedance Spectroscopy: Time-Resolved Decoupling of Transient Processes"

Electrochemical Impedance Spectroscopy (EIS) is a powerful tool for separating individual processes in electrochemical systems. However, conventional EIS requires the system to remain stationary during measurement, thereby limiting its applicability to transient phenomena. In thi...

Judd-Ofelt analysis of holmium-doped alumino-silicate optical glass prepared by MCVD combined with nanoparticle doping

We present a detailed Judd-Ofelt (JO) analysis of Ho3+-doped alumino-silicate optical fiber preforms in a wide range of compositions and prepared by both standard solution doping method as well as the more advanced nanoparticle doping. The absorption spectra were measured, the ab...

The impact of orography on the troposphere-to-stratosphere transport during a typhoon event in the tropics

Stratosphere-troposphere exchange (STE) plays a fundamental role in the global atmospheric budget of chemical constituents. The troposphere-to-stratosphere transport (TST), as a part of STE, can inject anthropogenic pollutants from the Earth’s surface into the stratosphere, chang...

Preprint of "Beyond Steady-State Limitations of Electrochemical Impedance Spectroscopy: Time-Resolved Decoupling of Transient Processes"

Electrochemical Impedance Spectroscopy (EIS) is a powerful tool for separating individual processes in electrochemical systems. However, conventional EIS requires the system to remain stationary during measurement, thereby limiting its applicability to transient phenomena. In thi...

Methylene blue modulates mitochondrial electron flow via multiple regulatory sites in isolated brain mitochondria: Implications for neurodegeneration

Methylene blue (MB) is a redox-active compound capable of modulating the efficiency of the mitochondrial electron transport system (ETS). We investigated the acute dose-dependent effects of MB on oxygen consumption and H₂O₂ production in isolated brain mitochondria. High-resoluti...

Design of Small Circularly Polarized Luminescence-Active Planar-Chiral Azaboroles

Abstract We report an enantioselective approach toward new planar-chiral azaboroles bearing the [2.2]paracyclophane unit and studies of their (chir)optical properties. Fusing the planar-chiral scaffold with a B,N-heterocycle led to the formation of a set of three substances, all...

Implementing Set-Theoretic Types

Set-theoretic types provide a rich type algebra that supports unrestricted unions, intersections, and negations, together with a decidable type constraint-solving algorithm known as tallying. These types are particularly well suited for typing dynamic languages, where functions o...

A multicenter, prospective – retrospective, epidemiological study in Czech and Slovak minors with spinal muscular atrophy treated with nusinersen

Abstract Background We used the Czech REaDY registry to collect and analyse data of paediatric patients with spinal muscular atrophy (SMA) who received nusinersen for five years. By sharing the results, we aim to increase healthcare professionals’ knowledge about this therapy. Re...