Centre National de la Recherche Scientifique

DNTTIP2 coordinates RNA exosome activities to ensure fidelity of human ribosome assembly

Abstract The RNA exosome-associated helicase Mtr4/MTR4 (yeast/human) is recruited by adaptor proteins bearing Arch-Interacting Motifs (AIMs) to selectively degrade RNA substrates. Although the exosome targets diverse RNAs, only a few adaptors have been identified. Here, we extend...

EvolutionaryConvergence on a Dihydrofolate ReductaseMutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis

Abstract Trimethoprim–sulfamethoxazole (SXT) remains central to melioidosis eradication therapy, yet the genetic basis of resistance evolution in Burkholderia pseudomallei is not fully defined. Using Burkholderia thailandensis as a biosafe surrogate, we subjected populations to s...

Urban transit experimentation as a mega-event legacy: public security in railway stations at the Paris 2024 Olympic Games

The urban sites of sport mega-events, such as the World Cup or the Olympic and Paralympic Games, have become stages for experimenting with extraordinary security and safety procedures. These procedures are designed to demonstrate the host country’s capacity to mobilize in the fac...

Accelerating biomass loss from forest disturbances across Europe

Abstract Forest disturbances are rising globally due to climate change and land-use pressures, weakening the terrestrial carbon sink. However, declines in aboveground biomass from tree cover loss remain poorly quantified, limiting our understanding of the role of disturbances in...

CO 2 ‐to‐CO Electrochemical Conversion With an Fe(I) Porphyrin Complex in Water

ABSTRACT Iron porphyrin complexes constitute a well‐established and versatile class of molecular electrocatalysts for the reduction of CO 2 to CO. In both organic and aqueous media, the reaction mechanism is typically proposed to involve the interaction of CO 2 with a formally de...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Pseudomonas aeruginosa mgtC gene is under the control of PhoP and CbrAB regulators, and its expression can be visualized in macrophages

ABSTRACT The MgtC virulence factor is important during the intramacrophage stage in both classical intracellular pathogens, such as Salmonella Typhimurium, and in extracellular bacteria that transiently encounter intracellular environments during infection, such as Pseudomonas ae...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

Scaling up fabrication of thin-film nanocomposite (TFN) membranes: Methods, challenges, and applications

Abstract Thin-film nanocomposite (TFN) membranes have received significant attention because of their excellent separation performance, structural flexibility, and tunability. As the demand for high-efficiency membrane technologies in industry grows, it becomes imperative to tran...

Improving ADRC Strategy for DC-Link Voltage Regulation in PV Grid-Tied Four-Leg Inverters Using an Adaptive Nonlinear High-Gain Observer

In practical photovoltaic grid-tied four-leg inverter systems (PV-GTFLIs), changes in radiation, temperature, and grid voltage magnitude cause significant disturbances, including DC-link voltage disturbance and power unbalance, which can impact the system’s dynamic responses, con...

Dietary behaviour of Sepedon (Parasepedon) ruficeps and Sepedon (Sepedomyia) nasuta (Diptera: Sciomyzidae) and the distribution of their snail prey in Benin (West Africa)

Sciomyzidae (Diptera) larvae live as predators and/or parasitoids of snails. They have potential economic importance as biological control agents against gastropods that are vectors of parasitic diseases. In the present study, the use of Sepedon larvae in schistosomiasis control...

Empirical evidence for a trade-off between reproduction and tumour dynamics in the freshwater cnidarian Hydra oligactis

Abstract Reproduction is a key life-history trait but often comes at the expense of somatic maintenance, including ageing and susceptibility to disease. While reproduction–immunity trade-offs have been experimentally demonstrated in the context of infectious diseases, whether rep...

Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe

All living organisms can enter a non-dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re-enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non-dividin...

Visual Pathways Involvement in Friedreich’s Ataxia Patients Without Macular Impairment

Objectives: Visual Evoked Potential (VEP) abnormalities in Friedreich Ataxia (FA) may result from dysfunction of retinal ganglion cells (RGC), post-retinal visual pathways, or both. Therefore, we aimed to clarify whether in Friedreich Ataxia (FA), abnormal neural conduction is du...

Paclitaxel-loaded nanostructured lipid carriers surface-functionalized with N6L for pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies, with limited therapeutic options. Despite advances in chemotherapy, such as FOLFIRINOX and Abraxane® (nab-paclitaxel) combined with gemcitabine, these treatments show limited effic...

Quantifying the Gap Between the Local Perceptions of Farming Households and What Experts Say About Climate Change in Haiti and the Dominican Republic

This study quantifies and assesses the gap between the perceptions of 550 farming households on the Caribbean island of Hispaniola and the opinions of 60 regional experts on climate change. This quantification draws on the traditional knowledge of farming households, which is bas...

SARS-COv-2, influenza and other respiratory virus co-circulation during an outbreak in a rural health zone in Democratic Republic of Congo, 2024–2025

Little is known about the global impact of co-circulation and co-infection of COVID-19 and influenza in Democratic Republic of the Congo (DRC). This study aims at analyzing data on SARS-CoV-2, influenza and other respiratory viruses collected during an outbreak response in the ru...

Dissent enhances the credibility of groups of Bayesian conformist decision-makers

When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimation provides tools for modelling decisions...

Labyrinthula merlionensis sp. nov.: A Novel Labyrinthulid Infecting Marine Diatoms

Labyrinthulomycetes are a class of fungus-like heterotrophic protists from the Stramenopiles lineage, recognized for their ecological role as decomposers and contributors to nutrient cycling. They colonize various substrates, from seaweed to terrestrial environments, utilizing ec...

Hydration-dependent exciton-phonon coupling in a metal-organic framework photocatalyst

Abstract Metal-organic frameworks (MOFs) have potential for light-harvesting applications owing to their tunable optoelectronic properties via building block selection. The presence of bound solvent in MOFs is known to impact gas adsorption properties, but little is known about t...