Centre National de la Recherche Scientifique

PercolationMechanisms in Transient Polymer Networksacross Dilute and Semidilute Regimes

Abstract Percolation in transient polymer networks remains poorly understood because reversible cross-links continuously reorganize the network structure. In this study, we investigated percolation in transient polymer networks by independently controlling network connectivity an...

Bioelectrical Impedance in Cardiovascular Health

Bioelectrical impedance (BI) is gaining significant attention for its potential in cardiovascular health monitoring and early disease detection. On the basis of the principles of tissue conductivity and body composition, BI operates by applying a low-amplitude alternating current...

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

Pressure-SelectiveMagnetic Switching via SpatiallySeparated Soft Interlayer and Rigid Charge-Transfer Intralayer

Abstract We report a pressure-responsive molecule-based magnet featuring a layered cyanido-bridged Co–W assembly, [{CoII(4-phenoxypyridine)4}3{WV(CN)8}2], exhibiting a distinct pressure-selective magnetic behavior. The compound forms two-dimensional charge-transfer layers with la...

Microencapsulation of Araucaria angustifolia bract extract: protection and bioaccessibility of phenolic compounds in chitosan-based systems

Abstract Purpose Native to South America, Araucaria angustifolia bracts (an underutilized by-product of seed processing) account for nearly 80% of the pinecone and are commonly discarded. The lyophilized aqueous extract obtained from these residues is rich in phenolic compounds (...

Altered excitation-inhibition balance in the somatomotor and default mode network in multiple sclerosis

Excitation-Inhibition (E/I) balance is a system-level principle governing healthy neuronal information processing. Its disruption has been implicated in the pathophysiology of multiple sclerosis (MS), yet in vivo characterization of E/I balance in MS remains under debate. In MS,...

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...

Coordinative chain transfer homopolymerization and copolymerization of bio‐sourced β ‐myrcene and butadiene promoted by iminopyridine iron complexes

Abstract A family of iron complexes bearing iminopyridine (ImPy) ligands with systematic variations on the N ‐aryl and pyridine moieties was evaluated as pre‐catalysts for the coordinative polymerization of β‐myrcene and butadiene. Upon activation with Al i Bu 3 and trityl borate...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Effects of home-based videoconference adapted physical activity on healthy aging

Abstract Aging induces muscle weakness and power decline in older adults, increasing the risk of falls. Adapted physical activity (APA) programs are effective in mitigating these declines. Recent innovations, including videoconferencing, offer alternative delivery modes, but thei...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

The skin of sorrow. The controversies between protected areas and tourism in a context of glacial retreat: Grande Motte (Tignes) and Girose (La Grave), France

The aim of this article is to identify the sources and drivers of conflict and conciliation in the case of two glacier redevelopment projects, drawn up in response to operating difficulties caused by climate change–driven glacial retreat and the declining popularity of summer ski...

Drainage divide dynamics modulated by erosion-driven landscape adjustment in a low-deformation setting

The Vosges Mountains (northeast France) are a mid-altitude mountain range with peaks reaching ∼1500 m a.s.l., in a low-deformation setting. Despite this, they maintain significant topographic relief (up to ∼1000 m), characterized by deeply incised valleys and broad, rounded uplan...

Melt burst events in a dominantly amagmatic lithosphere at Gakkel Ridge in the Arctic Ocean

Abstract Alternation of magmatic and amagmatic seafloor along the slow and ultraslow spreading ridges is common. Yet, temporal variation is obscured by sediments blanketing oceanic basement away from spreading centers. Here we analyze aeromagnetic data covering zero age to ~35 Ma...

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas

ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐r...

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

ABSTRACT Nanopore sequencing is a promising method for decoding synthetic digital polymers, but translocation signals are often complex. This study examines the influence of macromolecular design on the accuracy of nanopore sequencing. Nine phosphoramidite monomers were synthesiz...

Electrical control of exchange bias in sub-10 nm regime enabled by single-nanotube patterning

Achieving stable magnetization in sub-10 nm ferromagnetic layers represents a fundamental bottleneck in spin-orbit torque magnetic random-access memory development. While exchange bias potentially offers stabilization at such scales through antiferromagnetic coupling, conventiona...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...

CRISPR screens reveal MCT1-driven metabolic escape from SMAD3 inhibition as a therapeutic vulnerability

Resistance to therapy remains a critical challenge in cancer. This is exemplified by TGF-β pathway inhibitors which, despite broad clinical testing, have failed to deliver survival benefit. More precise SMAD3 targeting has shown preclinical promise, yet resistance mechanisms to S...