Central South University

Lifelong dictionary learning for dynamical system fault detection: A Bayesian perspective

Dynamical-system fault detection is essential for maintaining safe and reliable operation. However, industrial systems often evolve across operating modes, causing fixed monitoring models to lose accuracy when the data distribution shifts. Updating the model with new mode data ca...

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

To elucidate the molecular structure, oligomerization mechanisms, and roles of Ninjurin-1 (NINJ1) in regulated cell death (RCD) pathways (pyroptosis, necroptosis, ferroptosis, secondary necrosis, PANoptosis) and its dual role in cancer (tumor suppressor vs. pro-tumor factor). Sys...

Diagnostic utility of plasma metagenomic next-generation sequencing for bloodstream and localized infections in advanced HIV disease

Abstract Objectives To evaluate the diagnostic performance of plasma metagenomic next‑generation sequencing (mNGS) for suspected bloodstream infections (BSI) and localized infections in patients with advanced HIV disease. Methods We conducted a retrospective observational study o...

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

ABSTRACT Pancreatic cancer (PC) presents a significant global health challenge because of its high mortality rate, highlighting the urgent requirement for effective early diagnostic and therapeutic strategies. This study examined the function of phenylalanine metabolism in PC and...

Quenching Kinetics of Triplet-State Photosensitizers in Environmental Photochemistry

Abstract Triplet-state photosensitizers (3Sens*) are central to carbon cycling and pollutant degradation in sunlit surface and atmospheric waters, but their environmental roles remain only partly understood. Although the photophysical and photochemical properties of 3Sens* have b...

Frequency-Guided Feature Representation for Instance Segmentation in Aerial View Traffic Accident Scenes

Accurate instance-level perception of aerial view traffic accident scenes is the foundation of accident investigation. However, existing accident datasets mainly support event-level video analysis or coarse spatial localization, and rarely provide pixel-level vehicle masks togeth...

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study

Indiscriminate antibiotic use remains common in febrile patients with acute necrotizing pancreatitis (ANP), particularly during the early phase. Metagenomic next‑generation sequencing (mNGS) has shown diagnostic utility for infected pancreatic necrosis (IPN) and may offer a means...

Prediction of Joint Roughness Coefficient Using Metaheuristic-Optimized Random Forest Model

Reliable estimation of the joint roughness coefficient (JRC) is important for quantitative characterization of joint roughness and provides an important geometric parameter for subsequent joint shear strength assessment. However, single-parameter empirical models cannot fully cap...

Reconfigurable structural color generation in multicolor pixels using phase-change materials

We introduce multilayer structures based on phase-change materials for reconfigurable structural color generation. These structures can produce multiple distinct colors within a single pixel. Specifically, we design structures that generate either two or four maximally distinct s...

From bubble–particle aggregate formation to froth stability in mineral flotation: mechanistic links and controlling factors

Froth is an indispensable component of the flotation process, and its stability determines both the recovery and the separation efficiency. Accordingly, from the perspectives of the pulp phase and froth phase in the flotation system, this review elucidates the bubble-particle int...

Multi-process regulation of surface residual stress for improving SCC resistance of Al-Zn-Mg-Cu alloy high-lock nuts

Aerospace high-lock nuts, as core aircraft fasteners, face severe stress corrosion cracking (SCC) risks during long-term service, threatening flight safety. This study investigates the effects of closing, stress relief aging and shot peening on residual stress, SCC resistance and...

Prognostic Associations of BMI and Metabolic Syndrome With Outcomes After Anti‐ PD ‐1 Therapy in Recurrent or Metastatic Nasopharyngeal Carcinoma

ABSTRACT To evaluate the associations of body mass index (BMI) and metabolic syndrome (MetS) with outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M‐NPC) receiving anti‐PD‐1 therapy, and to develop a prognostic model for overall survival (OS). This mu...

SIRT3-dependent mitochondrial redox homeostasis protects against age-related tendon degeneration

Aims: Mitochondrial redox homeostasis is closely linked to the ageing processes of tendons, whether in normal or pathological conditions. This study employed an innovative approach to examine the role of sirtuin 3 (SIRT3) in mitochondrial dysfunction in the aged murine supraspina...

Recent advances in delivery strategies for CRISPR-based genome editing

Abstract The rapid development of CRISPR genome editing technologies has established a transformative paradigm within biomedical research, drug discovery, and gene therapy. Despite the robust nuclease activity and programmable targeting exhibited by these systems, the clinical tr...

Parent Material, Water Regime Shifts, and Fertilization Regulate Aggregate Stability and Cadmium Adsorption in Typical Subtropical Paddy Soils

Cadmium (Cd) contamination in paddy soils poses health risks, yet the role of aggregate-scale Cd binding remains poorly understood under interactive agricultural management. Unlike primary textural separates that are fixed by parent material, aggregates are dynamic and manageable...

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. We studied 28,842 diabetes-free UK Bioban...

Clinical characteristics and management of iatrogenic urological injuries in gynecological surgery: a retrospective analysis of 75 cases

To evaluate the incidence, clinical characteristics, primary management strategies, and long-term outcomes of urinary tract injuries after major gynecological surgeries. A retrospective analysis was conducted on a cohort of 34,568 major gynecological surgeries performed at our in...

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...

ContextFireAgent: A Multi-Role Consensus Agent for RGB Wildfire Monitoring

In real-world wildfire monitoring, haze, glare, refraction artifacts, and related visual effects can cause false alarms and missed detections. This study explores two implementations: ContextFireVLM and ContextFireAgent. ContextFireVLM fine-tunes Llama-3.2 Vision with LoRA to imp...

Topologically distinct intratumoral heterogeneity scores for predicting high-risk pathological grades in invasive lung adenocarcinoma: A multicenter study across four institutions

High-risk subtypes of invasive lung adenocarcinoma (IAC), particularly micropapillary- or solid-predominant patterns, are closely associated with poor prognosis. This multicenter retrospective study developed and validated a predictive model for the preoperative identification of...