Central South University

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

ABSTRACT Metabolic remodeling is one of the hallmarks of malignant tumors, and post‐translational modifications of proteins, such as succinylation, play an important role in the process of metabolic remodeling by regulating the function of metabolic enzymes. However, the role of...

Reliability and Validity of the Chinese Version of the Parental Acceptance Questionnaire (6‐PAQ) Among Parents of Children With or Without Hearing Loss

ABSTRACT Background The parental acceptance questionnaire (6‐PAQ) is a user‐friendly and contextually sensitive scale of psychological flexibility. Objective This research aimed to translate the original English version of the 6‐PAQ into Chinese and to test its psychometric prope...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms

AIM: Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the fron...

Hydration mechanisms of calcium sulfoaluminate (CSA) cements: the role of barium carbonate in sulfate-carbonate balance

Abstract This study investigates the partial and total replacement of CaSO 4 by BaCO 3 in calcium sulfoaluminate (CSA) cement systems through a systematic compositional series to examine the coupled effects of decreasing initial sulfate content, carbonate incorporation, and BaSO...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Strain‐Buffering Layered/Rocksalt Heterostructure Constructed via Oxygen Redox Activation for Durable O3‐Type Layered Transition Metal Oxides

ABSTRACT Harnessing anionic oxygen redox is pivotal for boosting the capacity of O3‐type layered transition metal oxides for sodium ion batteries (SIBs), yet it often triggers severe lattice distortion and irreversible oxygen release. Herein, we propose an in situ electrochemical...

Gut Microbiomes of Two Bamboo Locusts Reveal Divergent Metabolic Potentials

ABSTRACT The yellow‐spined bamboo locust ( Ceracris kiangsu ) and the green‐spined bamboo locust ( Ceracris nigricornis ) are two common bamboo‐feeding forestry pests in China. C. kiangsu has stronger migratory capacity and causes greater damage, yet comparative studies of their...

Fertility support needs of reproductive-age women based on the Kano model and ERG theory: a cross-sectional study

Amidst the declining fertility rate and population aging, providing effective fertility supports for reproductive-age women is urgently needed. Hence, understanding their fertility support needs is paramount. An observational design was implemented and the STROBE Checklist was ad...

Modelling injury severity of pedestrian crashes on urban road networks: a random-parameter spatial-joint logistic regression approach

Pedestrian crashes on urban road networks are commonly modelled separately for intersections or road segments, potentially overlooking the network-level dependence between physically connected entities. This study developed a random-parameter spatial-joint logistic regression app...

Glutathione S‐Transferase Omega 1 Promotes Macrophage Inflammation‐Associated Coagulopathy in Sepsis by S‐Glutathionylating ANXA5 to Enhance Its Ubiquitination

ABSTRACT Sepsis‐associated coagulopathy contributes to organ dysfunction and mortality. Macrophage‐mediated inflammation disrupts anticoagulant homeostasis, but the role of glutathione S‐transferase omega 1 (GSTO1) in this process remains unclear. Clinical samples from sepsis pat...

Mechanical behavior and fracture mechanisms of rock-backfill composites under different hole geometries and backfill conditions

Abstract Rock-backfill composites, as key load-bearing structures in deep mining, exhibit mechanical behavior and failure mechanisms that are predominantly controlled by excavation-induced hole geometry and backfill conditions. In this work, a series of uniaxial compression tests...

Curvature-controlled instability coupling in hypersonic three-dimensional boundary-layer transition

Abstract Boundary-layer transition on hypersonic lifting bodies is strongly affected by three-dimensional effects and surface curvature, which influence instability development and aerodynamic heating. However, the specific role of curvature in modulating transition behavior rema...

A Swirl-Driven Grouting Control Method for Non-Newtonian Fluids: 2.5D Seepage Model and Stability Analysis of Fractal-like Viscous Fingering

In porous media grouting, highly viscous non-Newtonian fluids often trigger viscous fingering (Saffman–Taylor instability) due to adverse mobility ratios, creating fractal-like preferential channels that severely weaken the reinforcement volume. To overcome this, a novel swirl-dr...

Exosome-packaged ILK from healthy female serum stimulate osteogenesis via the MAPK signaling pathway

The pathogenesis of osteoporosis (OP) is multifactorial, with impaired osteogenic differentiation of bone marrow stromal cells (BMSCs) serving as a fundamental pathological basis. Enhancing osteogenesis is a key strategy for OP therapy. Exosomes are recognized as promising cell-f...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Rural Sustainable Development Potential Under Ecological Prerequisite Constraints: Structural Differentiation and Spatiotemporal Evolution in the Leishui River Basin, China

Villages within Key Ecological Function Zones (KEFZs) are governed by a common ecological-priority regime, yet their rural sustainable development potential (RSDP) continues to diverge. This suggests that ecological conditions are not sufficient determinants of rural development...

Tortoise-Inspired Magnetically Actuated Soft Robot Enabled by Segmented Legs with Programmable Bending

Inspired by the natural curvature and jointed configuration of tortoise limbs, this paper presents a magnetically controlled soft robot based on a “programmable intrinsic curvature” design paradigm. When corrugated flexural notches are introduced into a single-material elastomeri...

Plasma proteome reflects tissue damage and clinical manifestations in patients with inflammatory myopathies

OBJECTIVE: Tissue-specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating cle...

Engineered hypoimmunogenic iPSC-derived mesenchymal stromal cells secreting high levels of functional FVIII ameliorate the hemophilia A phenotype

Background: Cell-based gene therapy represents a promising therapeutic avenue for genetic diseases such as hemophilia A (HA). However, clinical translation is limited by low transgene expression and host immune responses. Methods: Using CRISPR/Cas9, we targeted a codon-optimized...