Central South University

A Transfer Learning and Data Augmentation Approach for Classifying Field Images of Granite Residual Slope Soils

Granite residual and slope-wash soils are important disaster-prone geological bodies in the hilly and mountainous areas of Hunan Province, China. Their engineering classification has long relied on manual visual inspection and laboratory testing, which is inefficient and subjecti...

Experimental and numerical investigation of the effects of engine oil on combustion and particulate formation in a renewable bioethanol-gasoline engine

Ethanol is a promising biomass-derived renewable biofuel for internal combustion engines, offering substantial potential for carbon-emission reduction and knock suppression. This study combines experiments and numerical simulations to investigate the effects of engine oil on etha...

tACS and nervonic acid inhibit microglial overactivation via the Rap1 signaling pathway and ameliorate sleep deprivation-induced cognitive impairment

Sleep deprivation (SD) has become a critical global health concern, with consequences including cognitive decline. Transcranial alternating current stimulation (tACS) holds significant potential for improving cognitive impairment. This study aimed to evaluate the effects of tACS...

Engineered Hierarchical Porosity in Three-Dimensional-Printed Hydrogel Scaffolds Enhances Mesenchymal Stem Cell Therapy for Chronic Diabetic Wounds

Abstract Unhealing chronic diabetic wounds is a major clinical challenge, as it is rooted in the complex pathological microenvironment, including neuropathy, angiopathy, and chronic inflammation. Traditional treatment methods cannot fundamentally solve these problems. Inspired by...

Combined Protection Technology in Deep High In Situ Stress Environment of Metal Mines

Deep mining operations in metal mines face escalating challenges from high in situ stress environments, where conventional single-method ground control approaches often prove insufficient. This study proposes an innovative combined protection technology integrating four synergist...

Multi omics landscape of AGTRAP in ammonia induced cell death and cervical cancer progression

Abstract Background Cervical cancer (CESC) remains a leading cause of cancer-related mortality among women worldwide. Ammonia‑induced cell death, a recently identified metabolic cell death process, plays a significant yet incompletely understood role in tumor progression. Its reg...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes

Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high intraocular pressure (ph-IOP). Despite the established role of ferroptosis in RGC degeneration, specific molecular...

Advanced Strategies for Comfort and Mechanical Performance of 3D-Printed Concrete Wall Structures: A State-of-the-Art Review

3D-printed structures are an important direction in green construction, but layer-wise deposition forms interlayer interfaces that strongly influence the axial compressive performance of printed walls. This paper reviews interlayer bonding, anisotropy, strengthening strategies, a...

Vibration Characteristics of FG Shaft–Double-Disk Rotor System for Power Turbines

This study establishes a dynamic model for a functionally graded (FG) shaft–double-disk rotor system under rotational motion. The effective properties of the functionally graded material (FGM) are described using the Voigt homogenization scheme. Within the frameworks of first-ord...

Vesicular trafficking in immune regulation and disease: from intracellular sorting to intercellular communication

Vesicular trafficking is a fundamental mechanism that maintains cellular homeostasis, enables precise material transport, and regulates signal transduction in eukaryotic cells. In immune cells, vesicular trafficking supports dynamic membrane remodeling and activation-dependent ve...

Synergistic I 3 − Scavenging and Spontaneous Interphase Construction for Ultralong‐Life Zinc–Iodine Batteries

ABSTRACT Aqueous Zn–I 2 batteries combine safety, sustainability, and high theoretical capacity, making them a promising energy storage solution. However, their practical employment is impeded by challenges such as uncontrolled dendrite growth on the Zn anode, severe polyiodide s...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Large maximal subgroups of almost simple classical groups

Abstract A proper subgroup 𝐻 of a finite group 𝐺 is called large if | H | 3 ≥ | G | \lvert H\rvert^{3}\geq\lvert G\rvert . This paper characterises all the large maximal subgroups of almost simple groups whose socle is a finite simple classical group. For such a socle G 0 G_{0} a...

Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder

Abstract Individuals with methamphetamine use disorder (MUD) exhibited functional and structural brain recovery during abstinence. However, longitudinal neural changes of large-scale brain networks after prolonged abstinence remain unclear. Here, energy landscape analysis was app...

Endogenous spermidine biosynthesis contributes to fetal liver megakaryopoiesis and platelet production in mice

Metabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins remain incompletely defined....

Spatiotemporal Evolution of Land Use Patterns and Carbon Emission Effects in Hilly Regions

Land use and land cover change represent major anthropogenic carbon emission sources, yet most existing studies on landscape patterns and carbon emissions predominantly focus on plain urban agglomerations, with limited empirical evidence from terrain-restricted hilly regions. Tak...

Formal Governance or Compliance Constraint: ESG Committee Establishment and Corporate Environmental Penalties

Board-level ESG committees are increasingly used to formalize corporate sustainability governance, yet formalization does not ensure implementation. Existing research mainly evaluates disclosure, ESG ratings, and other favorable sustainability outcomes, and it remains unclear whe...

The Effect of Pore Size on Cell Ingrowth in PLLA/HA Scaffolds for Bone Tissue Engineering.

In bone regenerative medicine, scaffolds play a pivotal role in promoting cell adhesion, proliferation, and differentiation. Among the various materials employed for creating scaffolds, mixed materials composed of poly-l-lactic acid and hydroxyapatite (PLLA/HA) have emerged as a...

Autophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake

Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation; however, how selective autophagy regulates ferroptotic sensitivity remains incompletely understood. Here, we identify RAB8A as a selective autophagic substrate and negative regulator of fe...