Baylor College of Medicine

Hepatic reticuloendothelial distribution on sulfur colloid single-photon emission computed tomography/computed tomography is discordant with biochemical liver function in patients undergoing preradioembolization evaluation

Objective To determine whether qualitative technetium-99m sulfur colloid ( 99m Tc-SC) single-photon emission computed tomography/computed tomography (SPECT/CT) grading is discordant with conventional liver function assessment in patients undergoing preradioembolization evaluation...

Caspase-3 dependent, induction of barrier dysfunction and hyperpermeability in blood-brain barrier endothelial cells

BACKGROUND: Blood-brain barrier (BBB) dysfunction and associated microvascular hyperpermeability lead to brain edema and elevation of intracranial pressure in traumatic and ischemic brain injuries. Pro-inflammatory cytokines, interleukin (IL-1β) and tumor necrosis factor (TNF-α),...

A brief acceptance and commitment therapy intervention for individuals at risk of neurodegenerative disease: A translational study in inherited prion disease

Living at risk of a neurodegenerative condition such as inherited prion disease (IPD) is associated with substantial psychological burden, yet evidence-based supportive interventions are lacking. This unmet need is likely to grow as advances in biomarkers and predictive testing l...

Trends in Pediatric Urology Resident Operative Exposure and Autonomy: An 11-Year National Study

PURPOSE: Fewer urology residents are pursuing pediatric urology fellowship. Studies have examined potential associations between surgical residents' operative experience, autonomy, and exposure and fellowship pursuit. This relationship has not been examined with respect to pediat...

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation. Mitochondr...

Vitamin D supplementation for prevention of vitamin D deficiency in preterm and low birth weight infants

RATIONALE: Infants born prematurely or low birth weight (LBW) are at increased risk of vitamin D deficiency, poor bone health and rickets. Uncertainty exists regarding the need, dose and duration of vitamin D supplementation in preterm and LBW infants. OBJECTIVES: To evaluate the...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

The Transition of Youth With Diabetes From Pediatric to Adult Diabetes Care Services: A Consensus Report of the Joint Working Group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD), and the American Diabetes Association (ADA)

Young adulthood is a period of significant and unique physiological, psychological, sexual, and social upheaval. Related challenges can have an impact on effective diabetes self-management, with high rates of unplanned health care use recorded for many, and consequent increases i...

Association of patient and clinical characteristics with failed conversion of neuraxial anesthesia for intrapartum cesarean delivery among patients who had top-up of indwelling labor epidural catheters: a retrospective single center study

Background The primary aim of our study was to determine which patient and clinical characteristics were associated with failed conversion from neuraxial labor analgesia to neuraxial anesthesia for intrapartum cesarean delivery (CD) at our hospital.Methods The study included pati...

Platinum chemotherapy ages the liver

Platinum-based drugs cause mutations and liver aging in children treated for cancer

Updated COVID ‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

OBJECTIVE: We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECMO), and death in people with autoimmune rheumatic conditions. METHODS: We conduct...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...

Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System

Gastric mucosa atrophy is the cancerization field for gastric cancer development. Atrophic changes in the gastric mucosa can be assessed endoscopically and histologically. Gastric serology (e.g., pepsinogens and their ratio, and gastrin) may provide information on the functional...

Perceptions of Incidental Findings on Lung Cancer Screening Exams: A National Survey of Primary Care Clinicians and Radiologists

RATIONALE: Unlike other common cancer screenings, annual lung cancer screening often identifies a spectrum of incidental findings unrelated to lung cancer. While these findings could be actionable, how to best communicate and manage them can be a challenge, often falling upon pri...

Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes

Objective: Impulse control disorders (ICDs) are clinically important nonmotor features of Parkinson's disease (PD). Tremor-dominant PD (TD-PD) has been associated with greater cerebello-thalamo-cortical involvement, whereas postural instability/gait difficulty-dominant PD (PIGD-P...

Beyond The Usual Suspects: A Teenager's Diagnostic Odyssey

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CEDART study: protocol for a non-randomized feasibility study

Background: Family caregivers of persons with dementia face significant challenges in navigating hospital-to-community transitions. Community health worker-led interventions offer a promising approach to delivering culturally responsive psychosocial support and care navigation. H...

The Modern Urology Pipeline: Career Trajectories of Recent Residency Graduates

INTRODUCTION: Urology residency graduates face a pivotal transition when deciding on fellowship training and eventual practice setting. While traditionally a fellowship was a gateway to academia, recent trends reveal increasing pursuit due to job market concerns and perceived gap...

Artificial Intelligence in Echocardiography and Point-of-Care Ultrasound: Applications, Clinical Integration, and Future Directions

Artificial intelligence (AI) is increasingly used in echocardiography and point-of-care ultrasound (POCUS) to support image acquisition, view recognition, image-quality assessment, segmentation, automated quantification, disease classification, reporting, and bedside decision sup...