Baylor College of Medicine

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Parental Refusal of the Best Treatment: Nudges and Trust in Pediatrics

More effective and less toxic therapies are welcomed by clinicians and families and are the rationale and raison d'être for well-designed clinical trials. This is especially true for life-threatening diseases like childhood cancer. When parents opt for an existing and good treatm...

Perceptions of Safety and Fear of Seeking Emergency Care After 2025 Anti-Immigrant Policies

This cross-sectional study examines safety concerns and fear of seeking emergency care among English- and Spanish-speaking Latino patients following implementation of immigration policy changes in 2025.

American Rhinologic Society Expert Practice Statement: Indications and Recommendations for Posterior Nasal Nerve Ablation

ABSTRACT The goal of this American Rhinologic Society expert practice statement (EPS) is to provide an evidence‐based evaluation of the current literature on posterior nasal nerve ablation. Subtopics reviewed include the evidence for specific indications such as nonallergic rhini...

Human norovirus infection does not induce serotonin secretion in human intestinal organoids

Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. The primary symptoms of HuNoV-associated disease are vomiting and diarrhea; yet the mechanisms underlying these symptoms are poorly understood. Neuroactive hormones such as serotonin (5-hydroxytryp...

Immune correlates of protection are exposure-dependent: evidence from the Dominican Republic

Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This matters for vaccine e...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia

Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet nearly 40% ultimately relapse and die from their disease. High risk cases are typically referred for stem cell transplantation (SCT) in first remission, but because SCT is ass...

Inter-rater and intra-rater reliability of quantitative ultrasound in preterm infants: an observational cohort study.

= 81). The MiniOmni was the QUS device, and the smallest probe, CS probe (length 24 mm, range 2200-4700 m/s, and max depth 4.5 mm), was used for all subjects. Measurements were taken at the mid-tibia location. Inter-rater reliability was calculated using 2-way random-effects intr...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Race, Ethnicity, and Social Vulnerability in the Evaluation of Stillbirth.

OBJECTIVE: To examine the relationship between race, ethnicity, and social vulnerability on evaluation of stillbirth. METHODS: Retrospective cohort study examined stillbirths occurring at two sites within a single tertiary care center from 2015 to 2024. Cases included stillbirths...

Missed Opportunities for Multimodality Therapy in Resectable Pancreatic Cancer: National Disparities and Consequences for Survival

ABSTRACT Background Multimodal therapy (MMT) combining surgery and chemotherapy remains the optimal management strategy irrespective of sequence for resectable pancreatic ductal adenocarcinoma (PDAC). Determinants of MMT receipt and sequencing remain incompletely understood, part...

Firearm owners’ support for policies regulating firearms left in vehicles

Abstract Purpose Firearms stolen from vehicles are a leading source of gun theft in the US. In response, there has been growth in the number of proposed and enacted policies at the state and local levels. Yet firearm owners’ attitudes toward policies regulating firearms left in v...

Prevalence of Gastric Intestinal Metaplasia Among Patients with Active Helicobacter Pylori Infection Served by a Safety-Net Healthcare System

Gastric intestinal metaplasia (GIM) is a precursor of gastric cancer. Prior estimates of GIM prevalence in retrospective studies of U.S. populations may not be representative of true prevalence because gastric biopsies are not routinely performed for screening in the general popu...

Randomized phase II trial of liposomal cytarabine and daunorubicin with or without pomalidomide in newly diagnosed acute myeloid leukemia myelodysplasia-related

Not available.

Ultra-slow release of hydrophilic drugs via multilamellar–multivesicular liposomes formed by unsaturated phospholipids

Abstract Maintaining therapeutic drug concentrations at a target site while limiting systemic exposure is difficult for hydrophilic drugs, which rapidly diffuse from the injection site. Liposomes are widely used carriers, yet designs based on rigid, saturated phospholipids aim to...

Estimating Daily Taxon-Specific Tree Pollen at a 1-km Resolution in Atlanta, GA from 2020 to 2024

Abstract While tree pollen is a major trigger of respiratory allergies, the lack of high-resolution, taxon-specific exposure data has limited our ability to identify local taxa. Traditional pollen monitoring networks rely heavily on human efforts, thereby being limited to one sit...

Best practice recommendations for spoken and signed language interpreter-mediated clinical neuropsychological services

Objective: The increasing linguistic and cultural diversity of the United States population has intensified demand for equitable, patient-centered neuropsychological services. Yet, a persistent shortage of bilingual and multilingual neuropsychologists, across both spoken and sign...

Demographics, clinical features, and survival of patients with adenoid cystic carcinoma in major and minor salivary glands versus non-salivary sites: an updated SEER analysis

Introduction Adenoid cystic carcinoma (ACC) is a rare malignancy of secretory glands, most commonly arising in the salivary glands but also reported in the lung/bronchus, breast, skin, and other secretory gland tissues. Although typically slow-growing, ACC is also associated with...

Salivary Duct Carcinoma With Rhabdoid and Signet-Ring Cell Features Mimicking Invasive Lobular Carcinoma of the Breast: A Case Report and Review of the Literature

Salivary duct carcinoma is a rare, aggressive salivary gland malignancy that morphologically and immunophenotypically resembles breast ductal carcinoma. The rhabdoid variant is characterized by discohesive tumor cells with rhabdoid cytomorphology, frequent loss of E-cadherin expr...