Baylor College of Medicine

Social Risk Screening and Referrals in the Pediatric Inpatient Setting

BACKGROUND/OBJECTIVES: Many professional organizations recently recommended inpatient screening for social risks. Although prior studies have explored social risk screening rates in children's hospitals, many excluded community hospitals and lacked detail on screening practices....

Machine Learning to Distinguish Physiologic Causes of Hypoxemia After Bidirectional Glenn Using Bedside Markers

Background: Hypoxemia after bidirectional Glenn palliation can result from distinct physiological mechanisms that may produce similar arterial oxygen saturation. We evaluated whether routinely available bedside markers could recover physiological states encoded in a mechanistic v...

Single-cell multi-omics in IPF and COPD: from atlas to impact

Single-cell and spatial multi-omics technologies are transforming our understanding of the normal lung cellular repertoire as well the molecular and cellular networks of chronic lung diseases. In this review we focus on idiopathic pulmonary fibrosis (IPF) and chronic obstructive...

Aberrant one-carbon metabolism and ancestral genetics underlie edematous severe acute malnutrition

Edematous severe childhood malnutrition is distinct from the non-edematous form of malnutrition and remains a major cause of under-five mortality. Its etiology remains unclear, although aberrant one-carbon metabolism has emerged as a potential contributor. Here, we assess genetic...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Real-World Versus Centers for Medicare and Medicaid Services Estimates of Pediatric Retinal Detachment Repair Times

Purpose: To compare real-world pediatric retinal detachment (RD) repair times with the Centers for Medicare and Medicaid Services (CMS) estimates for complex RD surgeries. Methods: A cross-sectional survey was performed of complex pediatric RD perioperative times from pediatric r...

Accuracy of commercial pollen forecasts in the United States

Approximately 80 million Americans suffer from seasonal pollen allergies, and many rely on commercial pollen forecasts to guide exposure reduction and medication timing. However, these forecasts are proprietary, and their accuracy has never been comprehensively evaluated. Here, w...

Evaluating OpenEvidence Across Pediatric Subspecialties: A Guideline-Anchored Expert Review

OBJECTIVE: To evaluate the quality, safety, and citation characteristics of OpenEvidence across pediatric subspecialties. METHODS: Guideline-anchored clinical questions spanning high, moderate, and low evidence certainty across 6 pediatric subspecialties were submitted to OpenEvi...

Physical activity and blood pressure as predictors of cognitive function in the all of us research program

Abstract Physical activity (PA) is positively associated with cognition, whereas elevated blood pressure shows a negative association. However, most studies relied on subjective, self-reported measures of PA. In this study, we examined associations of PA (daily step count from Fi...

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

ABSTRACT Nuclear receptor corepressors (NCOR1/2) mediate the transcriptional activity of methyl‐CpG binding protein 2 (MECP2), and genetic variants in NCOR1/2 or MECP2 associate with autism or intellectual disability. However, it is unknown whether heterozygous NCOR mutations imp...

Changes in Dietary Behavior, Physical Activity, and Mental Health During a Lifestyle-Based Wellness Program for Women Re-Entering the Community After Incarceration: A Single-Arm Pre-Post Program Evaluation

Background Women re-entering the community after incarceration experience substantial chronic disease and mental health burdens. Evidence regarding lifestyle medicine programming in transitional housing settings remains limited. This study evaluated changes in dietary behavior, p...

Cerebellar Network Organization in Parkinson's Disease: Functional Connectivity across Motor and Cognitive Circuits

Abstract Background The cerebellum is increasingly recognized as a key contributor to cognitive reserve and network organization in Parkinson's disease (PD). However, the relationship of cerebello‐cortical and cerebello‐basal ganglia connectivity with cognitive status and nigrost...

Associations of Mild or Trace Valvular Abnormalities With Cardiac Remodeling in Older Adults: The ARIC Study

Background The impact of mild/trace valvular abnormalities on cardiac remodeling is not well understood, despite their association with poor cardiovascular outcomes. Methods Using data from 4684 participants in the ARIC (Atherosclerosis Risk in Communities) Study (2011–2013), age...

Gamified Augmented Sensorimotor Feedback During Balance Training Improves Postural Control and Nocturnal RMSSD

Background and Objectives: Augmented sensorimotor feedback may enhance motor learning during balance training, but whether these adaptations extend to cardiac autonomic regulation remains unclear. This study compared wobble-board training with gamified augmented feedback versus c...

Broad multiplex respiratory panel implementation and antibiotic prescribing in US emergency and urgent care departments: a staggered-adoption study

Abstract Objective: To evaluate the association between department-level implementation of broad multiplex respiratory pathogen panels and antibacterial prescribing. Design: Retrospective repeated cross-sectional staggered-adoption study with cohort-stacked difference-in-differen...

The Ripple Effects of Misattributed Parentage: The Systemic Family Impact of “Not Parent Expected” Discoveries

ABSTRACT Direct‐to‐consumer (DTC) DNA testing has led to a surge in misattributed parentage discoveries, often referred to as “not parent expected” (NPE) events. While prior research has focused primarily on the experiences of those discovering a parent was not as expected, this...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Impact of Extent of Surgical Resection on Survival in Patients With High-risk Neuroblastoma

Objective: The impact of extent of resection of the primary tumor on outcomes in patients with high-risk neuroblastoma (HRNB) remains uncertain. We evaluated this issue in patients with HRNB treated on a prospective trial of multimodality therapy. Summary of Background Data: Pati...

Primary Tumor Location and Lymphatic Spread in Papillary Thyroid Carcinoma

OBJECTIVE: Papillary thyroid carcinoma (PTC) frequently metastasizes to cervical lymph nodes. Surgical planning is often based on the presumed central-to-lateral pattern of spread. The extent of central and lateral neck dissection remains controversial, with recommendations large...

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...