Baylor College of Medicine

HIF1A-dependent induction of alveolar miR-147b dampens SARS-CoV-2-associated ARDS via direct targeting of viral RNA

BACKGROUND: Acute respiratory distress syndrome (ARDS) causes significant morbidity and mortality during viral pneumonia, including SARS-CoV-2 infections. Nevertheless, most patients with SARS-CoV-2 infections recover seamlessly without developing ARDS, suggesting the existence o...

Adapting the MasSpec Pen for noninvasive detection of oral cavity squamous cell carcinoma

Oral Cavity Squamous Cell Carcinoma (OCSCC) is a common and deadly form of head and neck cancer which disproportionately afflicts low- and middle-income communities. Since the majority of OCSCC lesions are visible within the oral cavity, visual exam-guided biopsy remains the stan...

Molecular Machines Enhance Insulin Release in Pancreatic Beta Cells

ABSTRACT The production and secretion of insulin by pancreatic beta cells plays a critical role in glucose homeostasis. Insulin signaling dysfunction typically results in diabetes mellitus, which affects over 415 million people worldwide. The development of new tools to induce in...

Impact of an unrestricted clear liquid fasting protocol on pediatric perioperative outcomes: a prospective interventional study

PURPOSE: Traditional preoperative fasting guidance (6-4-2) aims to reduce aspiration risk but frequently produces prolonged fasting and discomfort in children. We evaluated whether progressively liberalizing the clear-liquid fasting policy reduces fasting time and improves the pe...