Institution
Anhui Medical University
Recent research
- Health & Medicine
ABSTRACT Introduction Complete blood count (CBC) discrimination indices are widely used as low‐cost triage tools for microcytosis, but their diagnostic utility in population‐based samples with ferritin‐defined iron status is uncertain. We evaluated whether commonly used indices d...
- Biology
Abstract The rational design of selective kinase inhibitors is hampered by the conserved ATP-binding pockets. Vps34-IN-3, a potent VPS34 inhibitor developed by Genentech, Inc., showed ∼95-fold selectivity over the closely related PI3Kα, yet the atomic-level mechanism underlying t...
- Health & MedicineOpen access
Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...
- Health & MedicineOpen access
Clinical features of acute and chronic abdominal pain in children admitted to gastroenterology unit
Abstract Background The incidence of abdominal pain in children has been gradually rising. The study aimed to investigate the clinical characteristics of hospitalized children with abdominal pain for making the accurate diagnosis and treatment. Methods This study collected the cl...
- Health & MedicineOpen access
Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis
Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...
- Engineering & TechnologyOpen access
Abstract Osseointegration between titanium implants and surrounding bone is essential for the long-term success of implant surgery. However, mechanical injury during implantation can induce local oxidative stress, which compromises peri-implant osteogenesis. In this study, we dev...
- Health & MedicineOpen access
Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma
Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...
- Health & Medicine
primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....
- Health & MedicineOpen access
Case presentationOn 29 June 2021, a 36-year-old man with stage T4N1M0 differentiated thyroid cancer presented to the First Affiliated Hospital of Anhui Medical University for radioiodine therapy aimed at eliminating metastases.The patient had previously undergone bilateral radica...
- Health & MedicineOpen access
Aggressive B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, with a generally poor prognosis. This study aimed to evaluate the prognostic value of the endothelial activation and stress index (EASIX) score in patients with newly diagnosed aggressive B-cell lympho...
- BiologyOpen access
Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity
Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...
- Biology
Asthma is a heterogeneous and complex disorder characterized by chronic airway inflammation, presenting significant therapeutic challenges. Nitric oxide (NO) and carbon monoxide (CO) serve as pivotal gaseous signaling molecules, with elevated NO levels linked to disease exacerbat...
- AI & ComputingOpen access
Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...
- BiologyOpen access
Evidence on the association between prenatal exposure to organophosphate ester (OPE) and small vulnerable newborn components is limited and inconsistent. This study included 3208 mother-child dyads from the Ma'anshan Birth Cohort. In the first, second, and third trimesters, urine...
- Biology
INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....
- Society & EconomicsOpen access
This study aimed to examine the level of parental burnout and its associated factors among parents of adolescents with depressive disorders and to use qualitative interviews to further explain their caregiving experiences and psychological adjustment processes. An explanatory seq...
- Health & MedicineOpen access
Dental caries remains a prevalent public health disorder dominated by Streptococcus mutans . Novel biocompatible antibacterial agents are urgently required for caries control. Slightly acidic electrolyzed water (SAEW), rich in endogenous hypochlorous acid, boasts broad bactericid...
- Health & MedicineOpen access
Abstract Background Continuous glucose monitoring (CGM) compared to self-blood glucose monitoring (SMBG) has been a controversial topic regarding glycemic control in pregnant women with gestational diabetes mellitus (GDM), as well as maternal and infant outcomes. The aim of this...
- Climate & EnvironmentOpen access
Background Prenatal exposure to metal mixtures may influence newborn birth size, but the underlying metabolic mechanisms remain unclear. This study aimed to evaluate the associations of 19 individual maternal metals and metal mixtures during pregnancy with birth size indicators,...
- Climate & EnvironmentOpen access
Abstract Background Climate change may influence the transmission dynamics of enteric pathogens through changes in temperature, humidity, precipitation, and environmental exposure. Humid heat poses a significant threat, yet its synergistic impact on Other Infectious Diarrhea (OID...