Anhui Medical University

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Impact of the evolution of national ART guidelines and Initiation criteria on low–level viremia trends and predictors in Anhui Province: a sequential period analysis

Over the past two decades, China’s National Free Antiretroviral Treatment Program has undergone significant paradigm shifts. However, how evolving national ART guidelines and initiation criteria have shaped the long-term incidence of persistent low-level viremia (LLV) remains poo...

Multi-label arrhythmia classification from Holter scatter plots using deep learning and clinically oriented thresholds

Abstract Automated analysis of long-term Holter recordings is important for efficient arrhythmia screening, but most deep learning approaches rely on raw electrocardiographic waveforms. Heart-rate scatter plots provide a compact visual representation of rhythm dynamics and may su...

Pesticide residues in edible insects: sources, toxicological effects, analytical techniques and future prospects

With growing demand for sustainable protein sources, edible insects have gained attention for their high nutritional value and low environmental impact. However, in rearing systems that use agricultural by-products and organic waste as feed, pesticide residues may enter insects a...

Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study

Background/Objectives: Patients with post-traumatic knee contracture often present with limited range of motion (ROM) and impaired functional mobility, but functional performance may not be fully explained by ROM and pain alone. This study aimed to examine whether normalized vast...

HPV vaccine awareness, uptake, intention, and influencing factors among medical students in Anhui, China: A cross-sectional study

Although prophylactic vaccination is highly effective against human papillomavirus (HPV), HPV vaccine uptake among Chinese college students remains insufficient, and evidence among medical university students, particularly males, remains limited. Following the recent approval of...

IL-1α and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder

<title>Abstract</title> <bold>Background:</bold> It’s common comorbidity for Major Depressive Disorder (MDD), anxiety, and pain, underpinned by shared chronic inflammatory processes, this study aimed to identify etiological inflammatory biomarkers, focusing on MDD individuals wit...

Enhanced extracellular invertase production in Bacillus subtilis by boosting synthesis and secretion in a suitable chassis cell

<title>Abstract</title> Background Soybeans are an important agricultural product, but they contain a significant amount of raffinose, which can cause flatulence when fermented by intestinal microorganisms. Invertase InvDz13 from <italic>Microbacterium trichothecenolyticum</itali...

Serum brain-derived neurotrophic factor is associated with diabetic complications and glycemic control in type 2 diabetes: an exploratory analysis of the ADNI cohort

To investigate the association between serum brain-derived neurotrophic factor (BDNF) levels and the clinical profile as well as complications in patients with type 2 diabetes mellitus (T2DM). A total of 185 participants were enrolled, including 35 healthy controls, 111 T2DM pati...

Identification of Erectile Dysfunction From Routine Blood Test Data: Development and Validation of a Machine Learning‐Based Prediction Model

BACKGROUND: Erectile dysfunction (ED) is a prevalent male health disorder and a recognized sentinel marker for cardiovascular disease. Current diagnostic reliance on subjective questionnaires or invasive examinations limits early screening. AIM: We aimed to develop and validate a...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...

Endovenous thermal ablation combined with foam sclerotherapy is a safe and effective method for the treatment of lower extremity varicose veins: a multicenter retrospective analysis

To compare the safety, efficacy, and perioperative outcomes of radiofrequency ablation (RFA) and endovenous microwave ablation (EMA), each combined with foam sclerotherapy, versus traditional high ligation and stripping (HL/S) for symptomatic lower extremity varicose veins. The p...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus

Objectives Systemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is no...

Diagnostic Utility of Complete Blood Count Indices in Ferritin‐Defined Microcytosis Among United States Women Aged 18–49 Years

ABSTRACT Introduction Complete blood count (CBC) discrimination indices are widely used as low‐cost triage tools for microcytosis, but their diagnostic utility in population‐based samples with ferritin‐defined iron status is uncertain. We evaluated whether commonly used indices d...

A Kinetic Originof Vps34-IN-3 Selectivityfor VPS34 over PI3Kα Revealed by Supervised Molecular Dynamicsand Potential of Mean Force Analysis

Abstract The rational design of selective kinase inhibitors is hampered by the conserved ATP-binding pockets. Vps34-IN-3, a potent VPS34 inhibitor developed by Genentech, Inc., showed ∼95-fold selectivity over the closely related PI3Kα, yet the atomic-level mechanism underlying t...

Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis

Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...

Surface Modificationof Titanium with EGCG and HexamethylenediamineCoating for BMP-2 Grafting: An Investigation of OsteogenicProperties

Abstract Osseointegration between titanium implants and surrounding bone is essential for the long-term success of implant surgery. However, mechanical injury during implantation can induce local oxidative stress, which compromises peri-implant osteogenesis. In this study, we dev...

Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma

Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...

Clinical features of acute and chronic abdominal pain in children admitted to gastroenterology unit

Abstract Background The incidence of abdominal pain in children has been gradually rising. The study aimed to investigate the clinical characteristics of hospitalized children with abdominal pain for making the accurate diagnosis and treatment. Methods This study collected the cl...