Anhui Medical University

Clinical effectiveness of Er, Cr: YSGG laser compared with conventional rotary instrumentation for caries removal in primary teeth: a randomized split-mouth clinical trial

To compare the clinical efficacy of erbium, chromium-doped yttrium scandium gallium garnet (Er, Cr: YSGG) laser versus conventional air-rotor handpiece for caries removal in primary teeth and their effects on children’s anxiety and pain levels, to provide evidence for optimizing...

Hsa_circ_0001944 promotes colorectal cancer progression through the miR-665/IGF2BP1/PKM2 axis-mediated glycolysis

Colorectal cancer (CRC) is a highly heterogeneous malignancy with a poor prognosis. Although previous studies have suggested that circular RNA hsa_circ_0001944 is involved in CRC progression, its precise biological role remains unclear. This study aimed to investigate the functio...

Structural correlates of attentional performance in children with ADHD and their transcriptomic and neurotransmitter architectures

Attention deficits are a core feature of attention deficit hyperactivity disorder (ADHD), yet the biological architecture underlying attentional variation remains incompletely understood. We integrated structural MRI, transcriptomics, and neurotransmitter mapping to investigate a...

Nanoparticle‐Based Delivery Strategies for Targeted Protein Degradation

Targeted protein degradation (TPD) has fundamentally redefined pharmacological intervention, shifting from classical occupancy-driven inhibition to event-driven elimination of undruggable pathogenic proteins, holding great promise for treating various intractable diseases. Althou...

Senescent pulmonary epithelial cells-derived S100A10 drives epithelial-fibroblast crosstalk through inhibiting vimentin ubiquitination in pulmonary fibrosis

Pulmonary fibrosis is a chronic, lethal, and ageing-associated interstitial lung disease of unknown aetiology, involves pulmonary epithelial cell senescence and fibroblast activation. However, the underlying mechanism remains elusive. This study aims to investigate the role and p...

Development and validation of a risk prediction model for postoperative frailty in breast cancer patients

Background Patients who have undergone breast cancer (BC) surgery are a high-risk population for frailty. This study aims to analyze risk factors for frailty in these patients, develop a risk prediction model, and validate its predictive performance, thereby providing a reference...

Shared‐Output Aptamer‐Gated DNA Nanodevices Program NbaSPARDA Trans‐Cleavage for Metabolite and Drug Sensing

ABSTRACT Routing chemically distinct small‐molecule aptamers into a common nuclease trans‐cleavage pathway is constrained by the target‐specific output handles of conventional structure‐switching aptamers (SSAs). Shared‐output aptamer‐gated DNA nanodevices are designed so that re...

Prevalence and clinical correlates of abnormal lipid metabolism in young Chinese patients with first-episode drug-naïve major depressive disorder

Abnormal lipid metabolism (ALM) is frequently observed in major depressive disorder (MDD), yet its clinical correlates in young adults remain insufficiently elucidated. The aim of this study was to investigate the prevalence and clinical characteristics of ALM in young adult pati...

Addressing Span Imbalance and Semantic Complexity in Nested Medical Named Entity Recognition

As a fundamental task in biomedical natural language processing, Medical Named Entity Recognition (MNER) aims to identify and classify medical entities from unstructured medical texts. A major challenge in this task is the prevalence of nested entities, which arise from the synta...

Regulatory roles of G-quadruplexes and G-quadruplex-binding proteins across the enhancer and promoter of the HBV genome

Hepatitis B virus (HBV) infection poses a global threat to human health due to the limited availability of effective treatment options. Recent studies have shown that the structures of G-quadruplex (G4) are related to the pathogenesis of the virus and potential targets for antivi...

Unlocking near-infrared-II chemiluminescence for biomedical imaging

By arising light from relaxation of excited-state reactants, chemiluminescence avoids autofluorescence interference, thereby allowing unique benefits for in vivo imaging. As an active branch of optical imaging, no-excitation luminescence in the second near-infrared (NIR-II, 1000–...

Driver gene-based prognostic model benchmarked against machine learning survival models is associated with a CAF–TGFβ–EMT-like phenotype in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is molecularly heterogeneous, limiting conventional prognostic tools. Whole-genome resequencing of six HCC cases was used only to filter candidates. Somatically mutated genes were intersected with HCC-annotated entries from five predefined driver re...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Lactate-induced H3K9 lactylation disrupts the inner blood–retinal barrier by activating the PTK2–FMNL2 axis in diabetic retinopathy

Disruption of the inner blood–retinal barrier (iBRB) is a major cause of vascular leakage and vision impairment in diabetic retinopathy (DR), yet the metabolic mechanisms driving endothelial barrier failure remain incompletely understood. Here, we investigated whether lactate-ind...

Nursing care of a pediatric patient with anti-NMDAR encephalitis complicated by secondary epilepsy

Rationale: Autoimmune encephalitis in children often presents with neuropsychiatric symptoms and seizures and may progress to secondary epilepsy with prolonged functional impairment. Immunotherapy is the principal disease-modifying treatment, whereas comprehensive nursing care su...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells: A Comprehensive Review of Clinical Features, Molecular Pathology, and Therapeutic Advances

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells is a rare variant of malignant pancreatic tumor, accounting for less than 1% of all pancreatic tumors. The efficacy of neoadjuvant and adjuvant chemotherapy in patients with undifferentiated carcinoma of...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Impact of Low-Dose X-Ray Radiation Exposure on Lung Cancer Progression

Low-dose ionizing radiation is known to alter the biological properties of tumor cells. Although clinical computed tomography delivers low-dose radiation, the long-term radiobiological impacts of repeated low-dose X-ray exposure on the malignant progression of lung adenocarcinoma...

Prediction of growth abnormalities in monochorionic diamniotic twin pregnancies using estimated fetal weight discordance and clinical factors: a retrospective cohort study

OBJECTIVES: To explore whether integrating additional conventional clinical or ultrasonic predictors with mid-pregnancy estimated fetal weight discordance (EFWD) can enhance the predictive ability for fetal growth abnormalities in monochorionic diamniotic (MCDA) twin pregnancies....