Anhui Medical University

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

CTC-AttnNet: development and validation of an attention-based neural network for staging gastrointestinal malignancies

To develop and validate a noninvasive model for classifying T stage in gastrointestinal malignancies using circulating tumor cells (CTCs) and serum tumor markers and to compare the predictive value of CTCs with that of conventional tumor markers. This retrospective study included...

Neoantigen nanovaccines for cancer immunotherapy: design strategies, translational bottlenecks, and clinical prospects

Neoantigen vaccines have become an important direction in cancer immunotherapy because mutation-derived tumor antigens can induce highly specific T-cell responses while minimizing immune tolerance associated with tumor-associated antigens. However, their therapeutic performance r...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...