Anhui Medical University

Prediction of growth abnormalities in monochorionic diamniotic twin pregnancies using estimated fetal weight discordance and clinical factors: a retrospective cohort study

OBJECTIVES: To explore whether integrating additional conventional clinical or ultrasonic predictors with mid-pregnancy estimated fetal weight discordance (EFWD) can enhance the predictive ability for fetal growth abnormalities in monochorionic diamniotic (MCDA) twin pregnancies....

Head-up lateral positioning during emergence from anaesthesia after ambulatory adenotonsillectomy in children: protocol for a multicentre randomised controlled trial

Tonsillectomy and adenoidectomy are common paediatric surgeries, with > 50% of children experiencing postoperative respiratory adverse events (PRAEs). Existing mitigation strategies have limitations, and evidence on positional interventions (e.g. lateral/semi-reclined) specifical...

Gestational Exposure to the Food Processing Contaminant 3-MCPD Impairs Fetal Growth by Disrupting Placental Taurine Metabolism to Drive Vascular Senescence

Abstract 3-Monochloro-1,2-propanediol (3-MCPD), a common food contaminant, induces fetal growth restriction in mice by triggering senescence in the placental vasculature. Transcriptomic analysis reveals suppression of the taurine–hypotaurine pathway through downregulation of Fmo1...

SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease

Aims: Despite major advances with sodium–glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, progressive tubulointerstitial injury remains a major determinant of renal function decline in diabetic kidney disease (DKD), and the molecul...

Two‐Photon Laser Writing of Sub‐Diffraction Three‐Dimensional Luminescent Perovskite Architecture Embedded in Non‐Luminescent Perovskite

ABSTRACT As emerging high‐performance optoelectronic materials, metal halide perovskites display outstanding advantages in micro‐nano optoelectronic integration. However, high‐precision multidimensional processing and on‐demand dynamic modulation of the luminescent properties of...

Ti3C2T x MXene Combined with Laser Photothermal for High-Performance Oocyte Cryopreservation

Abstract Vitrification cryopreservation of oocytes represents a pivotal technique for the cryopreservation of female fertility. Nevertheless, conventional vitrification still faces the challenge of devitrification ice crystal damage stemming from an insufficient rewarming rate, w...

A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Background Superinfection is a major contributor to mortality in patients with severe fever with thrombocytopenia syndrome (SFTS). However, early identification remains challenging because detection of the pathogen causing the superinfection is often delayed. Objective This study...

Construction of composite biological soil crusts accelerates early-stage soil restoration in karst rocky desertification areas

Karst rocky desertification (KRD) represents one of the most severe forms of land degradation globally. Soils in these regions are characterized by structural instability, severe nutrient depletion, and fragmented microbial networks, all of which collectively impose formidable co...

Engineered Mitochondria-Targeted Biomimetic Hybrid Nanovesicles Ameliorate Rheumatoid Arthritis via Regulating Macrophage Autophagy and cGAS-STING Signaling

Abstract Despite decades of intensive investigation, rheumatoid arthritis (RA) remains a therapeutic challenge, primarily attributed to its intricate pathological microenvironment and poorly elucidated etiology. However, mitochondrial dysfunction and abnormal activation of the cG...

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

Abstract Multiple myeloma (MM) is a neoplastic disorder of plasma cells within the hematopoietic system and is characterized by osteolytic lesions. Despite significant advances, the molecular underpinnings of myeloma and its associated bone pathologies remain elusive, and there i...

Development, validation and comparison of the nomograms for predicting postoperative survival and recurrence in gastric cancer

Gastric cancer (GC) is one of the most common malignant tumors worldwide, with an overall five-year survival rate of less than 50%. The aim of this study is to construct and validate the new nomogram model for predicting recurrence and survival of GC patients after gastrectomy. W...

Metagenomic sequencing analysis of respiratory pathogens in the Jiangsu region of China: a multicenter epidemiological study (2025)

Abstract Background Acute respiratory infection (ARI) ranks as the leading cause of morbidity and mortality among children worldwide. Targeted metagenomic next-generation sequencing (tNGS) allows unbiased and comprehensive pathogen detection. This study aimed to investigate the e...

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development

This study aimed to integrate in vitro dissolution testing, in vivo pharmacokinetic (PK) studies, and computational simulation to develop a physiologically based biopharmaceutics model (PBBM) for fixed-dose combination ibuprofen/diphenhydramine citrate tablets, thereby evaluating...

Abnormal brain activity in patients with migraine without aura based on resting-state functional magnetic resonance imaging

Migraine is a neurovascular disorder that adversely affects both individuals and society. Although previous studies have observed abnormal brain activity in patients with migraine, the specific patterns of neural dysfunction and their relationship with clinical symptoms remain in...

eGDR and gastrointestinal cancer mortality in the UK Biobank: a prospective cohort study

Abstract Background This study examined the associations of estimated glucose disposal rate (eGDR), a surrogate of insulin sensitivity, and the insulin resistance indices TG/HDL-C and TyG with gastrointestinal (GI) cancer mortality in the UK Biobank. Methods We included 369,447 p...

Hyperglycemia alters B cell subsets contributing to osteoarthritis progression

Hyperglycemia and osteoarthritis frequently coexist as comorbid conditions, and both are characterized by chronic low-grade inflammation driven by aberrant B cell differentiation. However, the interplay between hyperglycemia, osteoarthritis, and aberrant B cell function has yet t...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

PANoptosis-related HLTF promotes prostate cancer progression and serves as a potential therapeutic target

Accumulating evidence indicates that pan-apoptosis plays a significant role in tumour progression, highlighting the importance of determining its relevance to tumour prognosis and treatment. This study aims to classify the molecular patterns of pan-apoptosis and explore the molec...

Cancer-associated fibroblasts-derived CAV1 promotes epithelial-mesenchymal transition and stemness in bladder cancer through activation of the LIF/STAT3 signaling pathway

Background Cancer-associated fibroblasts (CAFs) are key components of the bladder cancer microenvironment, but how specific CAF subpopulations drive malignant progression remains unclear. This study aimed to identify CAF driver genes and elucidate the role of caveolin-1 (CAV1) in...

The association between grit, social support, basic psychological needs satisfaction and psychological well-being among undergraduate nursing students: a cross-sectional study

The psychological well-being (PWB) among undergraduate nursing students represents an important focus within nursing education, with long-term implications for their academic persistence and future professional functioning. Grit has been widely acknowledged to be closely associat...