Anhui Medical University

Changing clinical spectrum and hospital burden of pulmonary aspergillosis before and during the COVID-19 era: a 15-year single-center retrospective study

Abstract Background Pulmonary aspergillosis (PA) encompasses a heterogeneous spectrum of fungal diseases, including invasive, chronic, and allergic forms. The hospital burden and clinical characteristics of PA during the COVID-19 era remain incompletely understood. Methods We con...

An Engineering‐Editable Hybrid Membrane‑Camouflaged DNA Origami Drug Enables Checkpoint Blockade and Immune Activation for Triple‐Negative Breast Cancer Immunotherapy

ABSTRACT The clinical response to immunotherapy in triple‐negative breast cancer (TNBC) is often limited by the immunosuppressive microenvironment, immune cell exhaustion, and multidrug resistance. Through a high‐throughput screen of 2,500 FDA‐approved drugs using a three‐dimensi...

Association between the ratio of serum uric acid to high-density lipoprotein cholesterol in early pregnancy and the incidence of gestational diabetes mellitus: a prospective cohort study

To investigate the ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) (UHR) in early pregnancy and the risk of gestational diabetes mellitus (GDM), and to evaluate its potential predictive value as a risk indicator for early identification of GDM among pregna...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Development and preliminary evaluation of a nomogram for predicting 30-day mortality after surgery for infective endocarditis: a single-center retrospective prediction-model study

Infective endocarditis (IE) remains associated with substantial early postoperative mortality. This study aimed to develop an exploratory, parsimonious nomogram for estimating 30-day all-cause mortality after IE surgery and describe its apparent performance, including exploratory...

Development and Validation of an Interpretable Machine Learning Model for Predicting In-Hospital Mortality in Diabetic Patients with Sepsis-Associated Acute Kidney Injury

Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, with poor prognosis. Diabetes may further increase adverse outcomes through infection susceptibility, immune dysfunction, and renal vulnerability. However, mo...

Comparison of clinical characteristics between children and adults with adrenal mass

Adrenal mass (AM) is a common disease with severe health problems. Its pathogenesis is different in adults and children; therefore, this study compared the differences in the clinical characteristics of AM between adults and children. This retrospective study collected the clinic...

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Impact of the evolution of national ART guidelines and Initiation criteria on low–level viremia trends and predictors in Anhui Province: a sequential period analysis

Over the past two decades, China’s National Free Antiretroviral Treatment Program has undergone significant paradigm shifts. However, how evolving national ART guidelines and initiation criteria have shaped the long-term incidence of persistent low-level viremia (LLV) remains poo...

Multi-label arrhythmia classification from Holter scatter plots using deep learning and clinically oriented thresholds

Abstract Automated analysis of long-term Holter recordings is important for efficient arrhythmia screening, but most deep learning approaches rely on raw electrocardiographic waveforms. Heart-rate scatter plots provide a compact visual representation of rhythm dynamics and may su...

Pesticide residues in edible insects: sources, toxicological effects, analytical techniques and future prospects

With growing demand for sustainable protein sources, edible insects have gained attention for their high nutritional value and low environmental impact. However, in rearing systems that use agricultural by-products and organic waste as feed, pesticide residues may enter insects a...

IL-1α and CRP as key inflammatory mediators linking neuropathic pain, anxiety, and depression in major depressive disorder

<title>Abstract</title> <bold>Background:</bold> It’s common comorbidity for Major Depressive Disorder (MDD), anxiety, and pain, underpinned by shared chronic inflammatory processes, this study aimed to identify etiological inflammatory biomarkers, focusing on MDD individuals wit...

Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study

Background/Objectives: Patients with post-traumatic knee contracture often present with limited range of motion (ROM) and impaired functional mobility, but functional performance may not be fully explained by ROM and pain alone. This study aimed to examine whether normalized vast...

HPV vaccine awareness, uptake, intention, and influencing factors among medical students in Anhui, China: A cross-sectional study

Although prophylactic vaccination is highly effective against human papillomavirus (HPV), HPV vaccine uptake among Chinese college students remains insufficient, and evidence among medical university students, particularly males, remains limited. Following the recent approval of...

Enhanced extracellular invertase production in Bacillus subtilis by boosting synthesis and secretion in a suitable chassis cell

<title>Abstract</title> Background Soybeans are an important agricultural product, but they contain a significant amount of raffinose, which can cause flatulence when fermented by intestinal microorganisms. Invertase InvDz13 from <italic>Microbacterium trichothecenolyticum</itali...

Identification of Erectile Dysfunction From Routine Blood Test Data: Development and Validation of a Machine Learning‐Based Prediction Model

BACKGROUND: Erectile dysfunction (ED) is a prevalent male health disorder and a recognized sentinel marker for cardiovascular disease. Current diagnostic reliance on subjective questionnaires or invasive examinations limits early screening. AIM: We aimed to develop and validate a...

Endovenous thermal ablation combined with foam sclerotherapy is a safe and effective method for the treatment of lower extremity varicose veins: a multicenter retrospective analysis

To compare the safety, efficacy, and perioperative outcomes of radiofrequency ablation (RFA) and endovenous microwave ablation (EMA), each combined with foam sclerotherapy, versus traditional high ligation and stripping (HL/S) for symptomatic lower extremity varicose veins. The p...

Serum brain-derived neurotrophic factor is associated with diabetic complications and glycemic control in type 2 diabetes: an exploratory analysis of the ADNI cohort

To investigate the association between serum brain-derived neurotrophic factor (BDNF) levels and the clinical profile as well as complications in patients with type 2 diabetes mellitus (T2DM). A total of 185 participants were enrolled, including 35 healthy controls, 111 T2DM pati...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...

Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus

Objectives Systemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is no...