Anhui Medical University

Phloroglucinol derivatives from Dryopteris championii

Two previously undescribed phloroglucinol derivatives, drychamphloros A and B (1 and 2), were obtained from the whole plant of Dryopteris championii, together with seven known congeners (3–9). Their structures were determined via ECD (Electronic Circular Dichroism) calculations i...

Association of four nutritional indicators with all-cause and cardiovascular mortality among older Chinese adults: a prospective cohort study

Malnutrition is prevalent among older adults, yet comparative prognostic performance of nutritional indices for mortality in Chinese elderly remains unclear. To compare Geriatric Nutritional Risk Index (GNRI), Prognostic Nutritional Index (PNI), Hemoglobin-Albumin-Lymphocyte-Plat...

Dynamic Changes and Diagnostic Value of Plasma Tryptophan and Its Metabolites in Different Stages of Hepatic Encephalopathy Detected by Ultra‐Performance Liquid Chromatography–Tandem Mass Spectrometry

ABSTRACT Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver disease. Early diagnosis remains challenging due to insidious onset and lack of stage‐specific biomarkers. Tryptophan (TRP) metabolism is closely linked to the gut–liver–brain axis and is dysr...

Rapidly deployable bio-based chitosan/phytate polyelectrolyte hydrogel coatings for flame retardancy and short-term thermal protection of cotton fabrics

Cotton fabrics are highly flammable cellulose-based textiles that are prone to rapid flame spread and smoldering, creating serious fire safety risks. Hydrogel coatings offer a promising route for textile fire protection because their water-rich networks can absorb heat through ev...

Discovery of Novel Pyridazine-Containing Nicotinamide Derivatives as Potent FTO Inhibitors for Acute Myeloid Leukemia

Abstract FTO has been recognized as a promising therapeutic target for acute myeloid leukemia (AML). However, the development of FTO inhibitors with anti-leukemia effects was still limited. Here, based on reasonable design and SAR, a total of 67 compounds were synthesized, among...

Corticothalamic circuits drive voluntary physical exercise-mediated relief of surgery-induced negative emotions in mice

Surgery-induced negative emotions (SINE), such as fear and anxiety, are common clinically and hinder postoperative recovery. Although physical exercise is known to modulate various affective disorders, the underlying mechanisms by which voluntary physical exercise alleviates SINE...

THBS1+ macrophages fuel pathogenic inflammation in alcohol-associated liver disease.

BACKGROUND: Alcohol-associated liver disease (ALD) is one of the most common chronic liver diseases worldwide, with a pathological spectrum ranging from simple steatosis to steatohepatitis and, ultimately, cirrhosis. Severe alcohol-associated hepatitis (sAH) arises acutely within...

Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects

Abstract Polygonatum cyrtonema (Huang jing) is widely used in both the food and traditional Chinese medicine industries. A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compounds─one norsesquiterpenoid (1), one pyridine alkalo...

Differential Psychological Effects of Daytime and Nighttime Heat Exposures on Anxiety: A Randomized Crossover Trial

Abstract Although heat exposure has been linked to adverse mental health outcomes, little is known about the different psychological effects of daytime and nighttime heat exposure. This study employed a randomized controlled crossover trial design. Between July and August 2025, 4...

Circulating RANKL is required for glucose homeostasis during pregnancy

Gestational diabetes mellitus (GDM) poses a significant health burden on women worldwide, necessitating the search for predictive, diagnostic and therapeutic approaches. Increasing evidence suggests that the receptor activator of NF-κB ligand (RANKL) is closely associated with GD...

Bisphenol mixtures and adverse childhood experiences in adolescent depressive symptoms: Interaction effects and sex differences

Adolescent depression is a major public health concern influenced by environmental and psychosocial factors. While bisphenol exposure and adverse childhood experiences (ACEs) have each been linked to depression, the mental health effects of emerging bisphenol analogues and their...

The role of external fixation in the management of ischial tuberosity pressure ulcers in elderly patients: a two-center clinical study

The management of ischial tuberosity pressure ulcers in elderly patients remains a significant challenge in surgical treatment, with high risks of wound dehiscence and recurrence following traditional flap reconstruction. This study aimed to evaluate the efficacy of a novel exter...

The roles of challenge and curiosity in deep learning and creative tendencies among Chinese medical undergraduates

Abstract Deep learning plays a crucial role in enhancing medical students’ clinical thinking and lifelong learning competencies, however, systematic research on its status and influencing mechanisms among multidisciplinary medical students remains insufficient. This study aims to...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Socioeconomic status and resilient coping in rare disease patients: the chain-mediating roles of social support and family resilience

Abstract Background In China, over 20 million individuals live with rare diseases (RDs), yet they continue to face systemic challenges including limited awareness among healthcare professionals, high misdiagnosis rates, diagnostic delays, and poor access to medications. Strengthe...

Lower Limb Muscle Mass Parameters Predict Short-Term Prognosis After Endovascular Intervention for Non-Thrombotic Iliac Vein Compression Syndrome With Varicose Veins

Background: Lower limb muscle mass depletion has been associated with poor outcomes in various vascular diseases, yet its prognostic role in patients with non-thrombotic iliac vein compression syndrome (NIVCS) and varicose veins (VC) undergoing endovascular intervention remains u...

Understanding Technology Anxiety Among Older Adults with Chronic Diseases: The Roles of Perceived Ease of Use and Perceived Usefulness

Purpose: To examine the associations of individual-level factors (eHealth literacy, chronic disease management self-efficacy, and coping style) and social-level factors (social support) with technology anxiety among older adults with chronic diseases, and to explore the potential...

Plasma interleukin-1 receptor antagonist in pediatric patients as a potential biomarker for sepsis-associated acute kidney injury: a cohort study

Our goal is to evaluate the potential of interleukin-1 receptor antagonist (IL-1Ra) as a biomarker for sepsis-associated acute kidney injury (SA-AKI). Specifically, we aim to explore the correlation between acutely elevated endogenous IL-1Ra and SA-AKI, and to identify the potent...

Quantitative assessment of china’s policies on the online sale of prescription drugs

Against the dual backdrop of the rapid advancement of big data-driven healthcare and the COVID-19 pandemic, China has gradually relaxed restrictions on the online sale of prescription drugs. However, the regulatory framework governing this sector remains in its early stage of dev...

Early-pregnancy per- and polyfluoroalkyl substances (PFAS), vitamin status, and risk of gestational diabetes mellitus: a prospective birth cohort study

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with endocrine-disrupting properties that may impair glucose homeostasis during pregnancy. Whether maternal vitamin D and folate status can attenuate PFAS-related metabolic risk remains unclear....