Anhui Medical University

Surface Modificationof Titanium with EGCG and HexamethylenediamineCoating for BMP-2 Grafting: An Investigation of OsteogenicProperties

Abstract Osseointegration between titanium implants and surrounding bone is essential for the long-term success of implant surgery. However, mechanical injury during implantation can induce local oxidative stress, which compromises peri-implant osteogenesis. In this study, we dev...

Elevated thyroglobulin due to a back musculature schwannoma in differentiated thyroid cancer: a case report

Case presentationOn 29 June 2021, a 36-year-old man with stage T4N1M0 differentiated thyroid cancer presented to the First Affiliated Hospital of Anhui Medical University for radioiodine therapy aimed at eliminating metastases.The patient had previously undergone bilateral radica...

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...

The endothelial activation and stress index (EASIX) as a prognostic predictor in aggressive B-cell lymphoma

Aggressive B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, with a generally poor prognosis. This study aimed to evaluate the prognostic value of the endothelial activation and stress index (EASIX) score in patients with newly diagnosed aggressive B-cell lympho...

Inflammation-Responsive NO-Scavenging and CO-Releasing Micelles Alleviate Pulmonary Inflammation and Th2 Cytokine Production in Asthma

Asthma is a heterogeneous and complex disorder characterized by chronic airway inflammation, presenting significant therapeutic challenges. Nitric oxide (NO) and carbon monoxide (CO) serve as pivotal gaseous signaling molecules, with elevated NO levels linked to disease exacerbat...

The effect of cochlear implantation in older adults: an umbrella review of systematic reviews and meta-analyses

INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....

A systematic review and meta-analysis of the effects of continuous glucose monitoring compared to self-monitoring of blood glucose on glycemic control and maternal and infant outcomes in women with gestational diabetes mellitus

Abstract Background Continuous glucose monitoring (CGM) compared to self-blood glucose monitoring (SMBG) has been a controversial topic regarding glycemic control in pregnant women with gestational diabetes mellitus (GDM), as well as maternal and infant outcomes. The aim of this...

Small vulnerable newborns and prenatal exposure to organophosphate esters: Insights from the Ma'anshan Birth Cohort

Evidence on the association between prenatal exposure to organophosphate ester (OPE) and small vulnerable newborn components is limited and inconsistent. This study included 3208 mother-child dyads from the Ma'anshan Birth Cohort. In the first, second, and third trimesters, urine...

On-demand caries prevention: on-site generated slightly acidic electrolyzed water as a potent and biocompatible anti- Streptococcus mutans agent

Dental caries remains a prevalent public health disorder dominated by Streptococcus mutans . Novel biocompatible antibacterial agents are urgently required for caries control. Slightly acidic electrolyzed water (SAEW), rich in endogenous hypochlorous acid, boasts broad bactericid...

Parental burnout among parents of adolescents with depressive disorders: an explanatory sequential mixed-methods study

This study aimed to examine the level of parental burnout and its associated factors among parents of adolescents with depressive disorders and to use qualitative interviews to further explain their caregiving experiences and psychological adjustment processes. An explanatory seq...

Agentic echocardiography report structuring for cardiovascular prediction and disease association discovery

Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...

Prenatal exposure to metal mixtures and newborn birth size in an industrial city: Evidence from cord blood metabolomics

Background Prenatal exposure to metal mixtures may influence newborn birth size, but the underlying metabolic mechanisms remain unclear. This study aimed to evaluate the associations of 19 individual maternal metals and metal mixtures during pregnancy with birth size indicators,...

Exploratory assessment of the clinical significance of the collateral system between the superior mesenteric artery and inferior mesenteric artery in laparoscopic rectal cancer surgery

Abstract Background Rectal cancer (RC) is a common and lethal malignant tumor, and surgical treatment is essential. The collateral system between the superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) remains controversial, and its potential clinical significan...

Humidex-related risk of other infectious diarrhea in Anhui, China: a multi-city study on spatial heterogeneity and socioeconomic modifiers

Abstract Background Climate change may influence the transmission dynamics of enteric pathogens through changes in temperature, humidity, precipitation, and environmental exposure. Humid heat poses a significant threat, yet its synergistic impact on Other Infectious Diarrhea (OID...

Association between PCSK9 and post-stroke cognitive impairment: a retrospective cohort study and predictive models establishment based on machine learning

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has gained increasing attention due to its involvement in lipid metabolism and neuroinflammation regulation. High PCSK9 levels are linked to an elevated risk of cerebrovascular events and small vessel diseases. However, system...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Reproducibility and validity of dietary polyphenols derived from 24-hour dietary recalls in the Anhui Lifestyle Validation Study

Abstract While 24-hour dietary recalls (24HDRs) are increasingly used to assess polyphenol-disease associations, their performance for measuring total dietary polyphenols and their subclasses remains unknown. In the Anhui Lifestyle Validation Study, 432 community-dwelling adults...

CIP2A–TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks

DNA double-strand breaks (DSBs) that occur during mitosis are primarily repaired by Polθ-mediated microhomology-mediated end joining (MMEJ). The CIP2A–TOPBP1 complex has been shown to tether broken chromatin at mitotic DSBs, but whether it coordinates with or functions independen...

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing prec...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...