Anhui Medical University

Curcumin alleviates metabolic dysfunction-associated steatotic liver disease via gut microbiota-dependent epigenetic alterations

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent, yet effective therapies remain limited. Curcumin (Cur), a polyphenol with well-documented metabolic benefits, shows therapeutic promise in MASLD, but its efficacy and underlying m...

Preoperative red blood cell distribution width is associated with prolonged mechanical ventilation and in-hospital mortality after acute type A aortic dissection repair

Red blood cell distribution width (RDW) has emerged as a potential prognostic marker in cardiovascular diseases. This study aimed to investigate the association between preoperative RDW and the incidence and mortality of prolonged mechanical ventilation (PMV) in patients with acu...

Endoscopic Endonasal Approach to the Medial Aspect of the Temporomandibular Joint Region

ABSTRACT Background The temporomandibular joint (TMJ) region is the most superolateral aspect of exposure via an endonasal corridor, while studies regarding the endonasal approach to this specific region are lacking. This study aimed to provide a detailed step‐by‐step surgical te...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

PSMα contributes to Egr1-dependent early neutrophil recruitment and host defense in a murine model of Staphylococcus aureus pneumonia

Abstract Background Staphylococcus aureus ( S. aureus ) pneumonia is associated with substantial morbidity and mortality. Neutrophils play a central role in host defense against bacterial infection and are significantly increased in the lungs during S. aureus pneumonia. However,...

Bone metastasis in newly diagnosed prostate cancer: development and external validation of a diagnostic prediction model based on inflammatory-immune indices and clinicopathological factors to support imaging decisions

Accurate identification of bone metastasis at initial evaluation is essential for staging and treatment planning in newly diagnosed prostate cancer (PCa). We retrospectively analyzed a prospectively maintained database of 355 patients from the Jixi Road Campus as the development...

Preprocedural estimated glomerular filtration rate and all-cause mortality after TIPS in cirrhosis: a single-center retrospective cohort study

Abstract Background : Renal dysfunction is increasingly recognized as an important determinant of prognosis in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS). However, the prognostic value of preprocedural estimated glomerular filtration r...

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

ABSTRACT Our previous work demonstrated that zinc oxide nanoparticles (ZnO NPs) undergo physicochemical transformations during environmental aging, forming a composite mixture of zinc hydroxide carbonate, nanosized ZnO, and Zn 2+ (termed aged ZnO NPs). Compared to their pristine...

Association between glycemic management during pregnancy and postpartum metabolic health outcomes among women with gestational diabetes mellitus

Abstract Background Glycemic management is standard for gestational diabetes mellitus (GDM), yet its impact on postpartum metabolic health, especially in late-onset GDM, remains uncertain. Objective To assess whether achieving glycemic control during pregnancy improves postpartum...

Bidirectional modification effects of non-optimal temperature and short-term exposure to fine particulate matter on cardiovascular mortality and their different subtypes: a time-stratified case-crossover study in multiple cities

Both fine particulate matter (PM 2.5 ) and non-optimal temperatures are well-recognized environmental hazard factors for cardiovascular diseases (CVD). However, the bidirectional modifying effects of these two factors on CVD mortality remain systematically understudied, particula...

Altered Intersubject Variability of Morphological Connectivity in Cerebral Small Vessel Disease and Its Associations With Gene Expression and Cell Types

Background Cerebral small vessel disease (CSVD) is a heterogeneous disorder; however, interindividual variability in morphometric brain connectivity remains unclear, as does its association with gene expression. Methods We enrolled 65 patients with CSVD and 35 healthy controls. I...

Design, Synthesis and Evaluation Donepezil-Based Dual BuChE/FAAH Inhibitors for Alzheimer’s Disease Therapy

Abstract Alzheimer’s disease (AD) is multifactorial, prompting multi-target therapy. A series of donepezil-based derivatives were designed, synthesized, and evaluated as dual inhibitors of human butyrylcholinesterase (hBuChE) and fatty acid amide hydrolase (hFAAH). Among them, le...

Synovial Metal Binding Proteins in Haemophilic Arthropathy: Potential Biomarkers and Therapeutic Targets

BACKGROUND: Haemophilic arthropathy (HA) is a chronic joint disease in haemophiliac patients, driven by recurrent bleeding and distinct from osteoarthritis (OA) and rheumatoid arthritis (RA) in its pathogenesis, including metal ion accumulation and inflammatory responses. AIM: To...

ipRGC-sensitive blue light exposure combined with exercise alleviates cognitive disorders and reverses pathological oscillations in mice

Non-pharmacological interventions including ipRGC-sensitive flickering blue light and physical exercise exert beneficial effects on cognitive function. However, whether their combined application confers additional benefits within a short intervention window where single interven...

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

The generation and characterization of CTRP9-CreERT2 knock-in mice for targeting endothelial cell muscle and adipose tissues

Vascular endothelial cells (ECs) exhibit significant diversity in different tissues. To elucidate the distinct physiological roles of individual EC subtypes, genetic mouse lines utilizing the Cre-loxP recombination system are crucial. However, there is still a lack of Cre mouse l...

Mechanism of HO-1 in alleviating sepsis-associated acute kidney injury via regulating mitochondrial proteostasis and targeted intervention with DNA nanomaterials

Sepsis-associated acute kidney injury (S-AKI) is a major driver of systemic mortality and chronic renal dysfunction, yet effective mechanism-based interventions are lacking. Clinical analysis revealed significant oxidative stress imbalance in patients with S-AKI, characterized by...

Multi‐Scenario Adaptive High‐Fidelity Self‐Healing Elastomer Based on Poly(Ionic Liquid) Containing Polyurethane for Temperature‐Pressure Sensing and Human‐Machine Interaction

ABSTRACT Skin‐friendly ionogels with multi‐scenario adaptive, high‐fidelity, and self‐healing performances were critical building units in wearable signal transmission devices. Traditional ionogels doped with small‐molecule ionic liquids (SMILAs) into polymers yielding weak inter...

A dual-channel deep learning framework integrating preoperative and intraoperative multi-phase data for predicting post-ablation recurrence in atrial fibrillation

Predicting atrial fibrillation (AF) recurrence after catheter ablation is essential for optimizing postoperative management. This study developed the Ablation-Clinical Fusion Transformer (ACFT), a dual-channel framework integrating structured intraoperative ablation sequences wit...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...