Research works

Integrated inference of cellular compositions and gene expression programs by deconvolution

While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic challenge. Consequently, accurate single-sa...

A Study on LLM-based Method for deriving Critical Safety Items to Enhance Submarine Operational Safety

Submarines pose a high risk of catastrophic incidents that may result in significant loss of life and severe degradation of strategic capabilities. In this context, the systematic management of Critical Safety Items (CSIs) is a fundamental requirement throughout the design, const...

Molecular Flux Density Distribution at the Pump Flange of a Test Dome for Measuring the Speed of a High Vacuum Pump

A numerical analysis has been obtained on the distribution of the molecular flux density qo(r) at the pump aperture of a test dome for measuring the speed of a high vacuum pump. The caluculation was carried out based on solving Clausing's integral equation by using iterative appr...

Trauma burden, coping patterns, and psychological symptoms in Ahiska Turkish children and adolescents displaced following the Ukraine war: a cross-sectional study

War-related displacement may affect youth mental health through direct trauma exposure, family-level trauma burden, and coping processes. Ahiska Turkish families displaced after the Ukraine war are a historically important group because recent displacement may occur against a bac...

Research on intelligent content generation and adaptive presentation in virtual simulation scenarios

Virtual simulation technologies have become indispensable in education, medical training, psychological therapy, and industrial applications. However, traditional virtual systems rely heavily on static pre-designed content and simple rule-based adaptations, resulting in limited p...

School-based sexual violence prevention: A systematic review

Purpose Sexual violence profoundly affects the health and development of children, adolescents, and young adults, representing a persistent challenge to public policy. This systematic review examined the effectiveness of school-based interventions aimed at prevention. Methods Eig...

Dynamic Capabilities May Not Be Efficient: A Multiyear Econometric Analysis of Multiple Performance Dimensions Shows the Robust Absence of Systematic Relationships

Although dynamic capabilities (DCs) theoretically constitute the evolution of a firm’s capabilities, the research tends to examine this phenomenon from a static perspective. This paper presents a methodology for capturing dynamic capabilities to understand their longitudinal effe...

Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates

Inborn errors of immunity (IEI) contribute substantially to morbidity in the Middle East and North Africa (MENA), particularly in the United Arab Emirates (UAE), where high consanguinity increases the prevalence of autosomal-recessive and complex genetic disorders. Regional IEI g...

Prolonged indolent clinical course in a high-risk chronic phase-CML patient without cytogenetic or molecular response: a case challenging established response paradigms

Chronic-phase chronic myeloid leukemia (CP-CML) is currently treated with tyrosine kinase inhibitors (TKIs), and the early achievement of cytogenetic and molecular milestones is strongly associated with improved clinical outcomes. Here, we describe the case of a 55-year-old woman...

Residual Neural FIR Filtering for Robust State Estimation

Finite impulse response (FIR) filters are inherently robust owing to their finite-memory structure and independence from initial state statistics. However, they often lack the adaptivity required for time-varying environments. While recent neural-network-based FIR approaches addr...

Postural risk factors for work-related musculoskeletal disorders during manual versus device-assisted lower-limb stretching

Work-related musculoskeletal disorders (WMSDs) are prevalent among physiotherapists and occupational therapists due to the physically demanding and repetitive nature of manual therapy techniques. Stretching requires therapists to exert substantial force while holding static postu...

A CNN-based Unsupervised Learning System for Detecting Stator Pin Insertion Defects in Blower Motors for Industrial Environments

This study proposes a system for detecting defective automobile blower motors based on deep one-class classification (DOCC). DOCC determines defects by learning only normal data to overcome the limited data environment experienced in the actual industrial sites where it is diffic...

Exploring the role of place visitation big data on small area health measure estimation

Population-level health measures at small geographic scales (e.g., census tracts), including health conditions, preventive behaviors, risk factors, and overall health status, are crucial for guiding effective health planning and policymaking. It has been well established that dem...

Two Cases of Type 2 Thyroplasty Performed during Pregnancy (First to Second Trimester)

痙攣性発声障害（spasmodic dysphonia：SD）に対する甲状軟骨形成術2型（type 2 thyroplasty：TP2）は有効性が確立された手術であるが，妊娠中の施行に関する報告はない。今回我々は，音声障害により日常生活・業務に支障をきたした2例の妊婦に対し，局所麻酔下TP2を妊娠初期～中期に実施し，良好な母...

Genome-wide characterization of the bZIP gene family in Rattus norvegicus and expression profiling analysis during brain development

The brown rat ( Rattus norvegicus ) serves as a cornerstone model organism in biomedical research, particularly for understanding physiological homeostasis and stress responses. The basic leucine zipper (bZIP) transcription factor family is a pivotal regulatory network involved i...

Scale-Dependent Dimensional Trapping: A Topologically Invariant Unified Framework for Galactic Dynamics, Quantum Leakage, and Cosmological Observables

We present Scale-Dependent Dimensional Trapping, a scale-invariant geometric framework that unifies galactic dynamics, quantum gravity attenuation, and cosmological observables without requiring non-baryonic dark matter, dark energy constants, or fine-tuned parameters. By establi...

Prevalence and factors associated with maternal near-miss at the Regional Hospital Bamenda

Maternal Near Miss (MNM) is a woman who nearly died but survived a complication that occurred during pregnancy, childbirth or within 42 days after childbirth. It assesses and monitors the activities aimed at the prevention of maternal mortality. A 2019 systematic review estimated...

Delayed rupture of vaginal wall haematoma causing secondary postpartum haemorrhage—successful management with bilateral uterine artery embolisation: a case report

Secondary postpartum haemorrhag (PPH), defined as excessive bleeding occurring between 24 hours and 6 weeks after delivery, is less common than primary PPH but may cause substantial maternal morbidity if diagnosis or intervention is delayed. Vaginal wall haematomas are usually re...

Molecular-Scale Observation of Flexibility and Thermal Motions in Surface-Coordinated Polymers

We report a molecular-scale study of a one-dimensional coordination polymer formed on a Cu(111) surface. A tailored ligand, 2,7-dicyano-9,9-dimethylfluorene (DCF), was designed to reduce interactions with the surface while enabling directional coordination with Cu adatoms. Scanni...

Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls

PURPOSE OF REVIEW: We review potential applications and pitfalls of urinary biomarkers in people with heart failure (HF). RECENT FINDINGS: Albuminuria may indicate kidney damage and guide prioritization of medications in HF. Urine sodium is useful in guiding diuretic management....