Research works

Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology

Pediatric central nervous system tumors remain a leading cause of cancer-related mortality in children, while their diagnosis, risk stratification, and therapeutic management increasingly depend on integrated molecular characterization. However, representative tumor tissue is oft...

Sliding-mode fracture behavior of friction lap-welded aluminum-GFRP hybrid joints utilizing a thermoplastic interlayer

The Mode-II fracture response of friction lap-welded aluminum-to-thermoset glass fiber reinforced polymer (GFRP) composite joints, incorporating an interlayer made of thermoplastic material, was investigated through an integrated experimental and numerical approach. End-notched f...

Impact of Observation Density of Next-Generation GeoHIS on Global Numerical Model Performance: A KIM-OSSE Study

The geostationary hyperspectral infrared sounder (GeoHIS) provides atmospheric variables at high spatiotemporal resolution. Consequently, GeoHIS can provide valuable information for improving real-time forecasting and enhancing the performance of numerical weather prediction (NWP...

Effects of a novel youth sexual and reproductive health programme in Zambia: An experimental study

Objective: Knowledge about sexual and reproductive health is often limited among adolescents in Zambia, and this limitation may have negative health effects. Although programmes have been developed to increase such knowledge, these programmes can sometimes be seen as being in con...

Causes of death and mortality patterns in clozapine-treated patients: 17-year retrospective cohort study

Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...

Subcultural desires: Attraction to twinks, jocks, and bears is associated with sexual preferences for specific body types, gender expressions, and racial groups

Sexual subcultures such as twinks, jocks, and bears have provided sexual minority men with a means of self-definition and social connection within a broader LGBTQIA+ community. The present study explores the preferences associated with attraction to these subcultures, shedding li...

7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson’s disease

PURPOSE: Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra (SN). Imaging biomarkers sensitive to nigral pathology are limited. This study evaluated susceptibility changes in the SN using quantitative susceptibility mapping (QSM) and s...

The endothelial activation and stress index (EASIX) as a prognostic predictor in aggressive B-cell lymphoma

Aggressive B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, with a generally poor prognosis. This study aimed to evaluate the prognostic value of the endothelial activation and stress index (EASIX) score in patients with newly diagnosed aggressive B-cell lympho...

Exploring the hydrogen abstraction pathway in HOM formation from α -pinene photooxidation systems under varying NO conditions

Abstract. Highly oxygenated organic molecules (HOM) are formed via autoxidation during ⚫OH-initiated oxidation of α-pinene. We investigated the relative contributions of OH-addition and hydrogen (H)-abstraction to HOM formation from α-pinene photooxidation under varying nitrogen...

Isocitrate dehydrogenase (IDH) as target for anticancer therapy in brain and gastrointestinal cancers

Isocitrate dehydrogenase (IDH) enzyme system plays a central role in cellular metabolism, growth, and differentiation, and its mutations are associated with alterations of the cell cycle and production of oncometabolites, promoting tumor development. In this narrative review, we...

Ultrasound‐Driven Interfacial Electron Modulation Reprograms Mitochondrial Metabolism for Glioblastoma Therapy

Glioblastoma (GBM) remains difficult to treat because the restrictive blood-brain barrier (BBB), the hypoxic tumor microenvironments, and mitochondrial electron transport chain (ETC)-driven metabolic adaptability jointly limit therapeutic delivery and efficacy. Selective disrupti...

Long-Term Weight Variability Is Associated with Higher Triglyceride Concentrations After Accounting for Long-Term Weight Slope

Background: Long-term fluctuations in body weight may reflect changes in energy balance, illness, or intentional weight loss. However, their association with subsequent triglyceride concentrations remains uncertain. Objective: To examine the association between long-term weight v...

Implementing prospective probabilistic scheduling of surgical cases to yield more predictable utilisations

We studied the impact of a prospective, probabilistic scheduling method to replace surgeon-led booking, balancing contradictory goals of maximizing theatre utilised time while minimizing risk of over-utilised time. Implemented in an NHS Scotland hospital, the study analyzed 2420...

Impact of oxygen and hydrogen traces on the focused ion beam sputter rate and secondary ion mass spectrometry intensity detection of graphite

Trace amounts of oxygen and hydrogen can strongly influence the formation of negative carbon ions during focused ion beam–secondary ion mass spectrometry (SIMS) analysis of graphite. In this study, the sputtering behavior of graphite and the detection of single and clustered carb...

Antimicrobial effectiveness within a new paradigm of infrastructure

Antimicrobials form the backbone of modern medicine and represent a foundational pillar of economic productivity. Overuse and misuse have led to a rising trend of antimicrobial resistance (AMR), depleting the efficacy of existing antimicrobials, necessitating conservation through...

Evolution of water clarity across the Beijing-Tianjin-Hebei region over the past four decades (1984–2024): Driven by hydrological expansion and anthropogenic intervention

Given escalating water scarcity and rapid urbanization, characterizing the long-term evolution of surface water environments across the Beijing-Tianjin-Hebei (BTH) region is vital for coordinated regional development. Using Landsat imagery spanning 1984–2024, this study quantifie...

Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response

To investigate the association between preoperative anxiety and opioid tolerance in patients undergoing primary hip arthroplasty, focusing on heterogeneity across opioid types and the mechanisms underlying this association, this retrospective cohort study identified 1763 such pat...

Durability of wrist denervation for osteoarthritis: a multicentre outcome study

INTRODUCTION: Traditional surgical treatments for wrist osteoarthritis, such as arthrodesis or arthroplasty, are invasive and irreversibly compromise joint motion. Wrist denervation offers a less invasive alternative aimed at pain relief while preserving mobility. However, its du...

Research on the Impact Mechanism and Spatial Effects of the Digital Economy on Regional Economic Resilience in the Yellow River Basin of China

Against a backdrop of rising macroeconomic uncertainty, the digital economy has become a key driver of regional economic resilience. However, research on this relationship still requires further refinement for the Yellow River Basin, a special region characterized by ecological r...

Neuropeptide Alterations in Type 2 Diabetes Mellitus: A Meta‐Analysis of Circulating Spexin and Galanin Levels

ABSTRACT Background Spexin and galanin are neuropeptides involved in glucose homeostasis, insulin sensitivity, appetite, and energy metabolism. We conducted a systematic review and meta‐analysis to synthesise evidence on circulating spexin and galanin concentrations in patients w...