Research works

From Antagonism to Coevolutionary Regulation: Multidimensional Phage–Biofilm Interaction Networks and Translational Targeted Anti-Infection Strategies

Bacterial biofilms possess inherent physical barriers and structural heterogeneity. These features pose a major obstacle to clinical anti-infective therapy. This review systematically examines the dynamic interplay between phages and bacterial biofilms, which ranges from antagoni...

Indigenous Strengths, Community Care, and Cancer Disparities: Insights from Talking Circles with American Indian Tribes in North Carolina

Abstract Background: American Indian communities experience disproportionally higher cancer incidence and mortality rates compared to other populations in North Carolina (NC). As part of the SAICEP (Southeastern American Indian Cancer health Equity Partnership) initiative, talkin...

Dual-therapeutic niraparib-loaded chitosan nanoparticle–alginate hydrogel with adipose-derived stromal cells promotes functional and histological recovery after spinal cord injury

Background: Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration. Methods: Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs)...

Association Between Joint Effusion and Degenerative Osseous Changes of the Temporomandibular Joint: A Systematic Review and Meta‐Analysis

ABSTRACT Background Joint effusion (JE) on magnetic resonance imaging (MRI) has been proposed as a potential imaging marker of intra‐articular inflammation and degenerative involvement in temporomandibular disorders (TMDs). However, its association with temporomandibular joint de...

Psychometric validation of the German Cancer Worry Scale as a patient-reported outcome measure in individuals undergoing genetic testing for hereditary cancer risk

Abstract Background Cancer worry is a key psychosocial outcome among individuals undergoing genetic testing for hereditary cancer risk, yet validated patient-reported outcome measures (PROMs) in the German-speaking context are limited. We aimed to evaluate the psychometric proper...

Recruitment by Exporters: Implications for Labour Demand Concentration and Labour Market Matching

ABSTRACT Leading up to Slovenia's entry into the EU, Slovenian exporters experienced large reductions in tariffs with their main trading partners, the EU member countries. We exploit variation in exports during this period to examine the role of exporting in the firms' recruiting...

Engineering the Electrochemical Interface With Polyborate for High‐Selectivity Adiponitrile Electrosynthesis

ABSTRACT The electrochemical dimerization of acrylonitrile (AN) to adiponitrile (ADN) offers a sustainable pathway for producing Nylon‐66 precursors. However, its efficiency is severely limited by competitive hydrogen evolution, often demanding toxic heavy metals and non‐electroc...

Hierarchical Rainfall-Intensity-Aware Hourly Precipitation Merging Based on Tree-Model Routing and LSTM Conditional Regression: Spatiotemporal Generalization and Hydrological Utility

In mountainous regions with uneven gauge coverage, satellite precipitation errors are amplified by nonlinear rainfall–runoff processes, while conventional hourly merging often relies on a single continuous regression that inadequately handles zero inflation and intensity heteroge...

Density Estimation in Heritage Timber Elements Using Resistograph Drilling Resistance

Accurate structural diagnosis of timber elements in historic buildings requires minimally invasive and operationally reliable assessment methods compatible with heritage conservation principles. This study aims to estimate timber density in situ directly from Resistograph drillin...

E8 Root Vector Decomposition into 10 Phi-Stable Quantum Channel Families — E8 Intelligence Research

The 240 E8 root vectors decompose naturally into 10 interpenetrating families of 24 vectors each, where each family corresponds to a distinct phase relationship with the 132Hz phi-coupled carrier. This decomposition explains why the 72-element Fibonacci cycle (72 = 3 × 24) produc...

Apelin overexpression remodels aged mesenchymal stem cells to generate miR-486a-5p-enriched exosomes that drive cardiac repair

Abstract Background Mesenchymal stem cell (MSC)-based therapy has shown promising cardioprotective effects in myocardial infarction (MI), yet the therapeutic utility of aged MSCs (AMSCs) is substantially compromised by replicative senescence and functional decline during in vitro...

Institutional barriers and professional integration of physicians with an Arab migration background in Germany: a qualitative study

Abstract Background Germany faces a persistent physicians shortage f, particularly in hospitals and rural regions. Migrant physicians, especially from Arab countries, represent a crucial component. However, their professional integration is shaped by complex licensure procedures,...

Agricultural Industry Agglomeration and Carbon Emission Intensity: A Systems Perspective on Resilience and Digital Development

Decarbonizing agriculture depends not only on the efficiency of individual production activities but also on coordination among production, processing, and service activities. From a systems perspective, this study treats provincial agriculture as an interconnected industrial sys...

THE ROLE OF INTERACTIVE SIMULATION AND DIGITAL TECHNOLOGIES IN DEVELOPING PRACTICAL SKILLS OF MEDICAL STUDENTS IN UROLOGY

The integration of innovative educational technologies into medical education has become an essential component of improving the quality of professional training. Urology requires students to acquire theoretical knowledge, clinical reasoning abilities, and practical procedural sk...

The Effects of Self-Regulated Mathematics Instruction with Integrated Cognitive and Metacognitive Strategies on High School Students’ Self-Regulation Skills, Attitudes Toward Mathematics, and Motivation in Mathematics

(1) Background: In this study, the effect of the Structured Mathematics Teaching Plan Integrating Cognitive and Metacognitive Strategies Based on Self-Regulated Learning (MLP-SRL) on 11th-grade students’ self-regulation skills, attitudes toward mathematics, and motivation in math...

Digital Media Literacy in the Age of AI: Exploring the Comfort–Competence Gap Among University Students in the United Arab Emirates

Artificial intelligence increasingly mediates how citizens access information, making digital media literacy a condition for informed participation. This exploratory study conceptualizes a comfort–competence gap, whereby students report confidence and ease in using AI tools but a...

Specialized Nutrition Products in Pediatric Medical Care: Clinical Applications, Formulation, Regulation, and Future Directions

Specialized nutrition products are often used as a component of nutrition care across a spectrum of acute and chronic pediatric medical conditions. These products differ from conventional foods due to their clinical purpose, composition, and context of use, yet these distinguishi...

BESIII Discovers Y(4230) and Y(4710) in K_S⁰K_S⁰J/ψ and K⁺K⁻J/ψ Cross-Sections — E8 Intelligence Research

FINDING: BESIII reports new vector charmonium-like states Y(4230) and Y(4710) via K_S^0 K_S^0 J/ψ and K^+K^-J/ψ cross-sections; additional Born cross-section measurements for multi-strange baryon final states. | MATH: Masses: M[Y(4230)] ≈ 4.230 GeV, M[Y(4710)] ≈ 4.710 GeV. Cross-...

A DNA Nanoplatform with Rolling Circle-DNAzyme Feedback Programming for Autonomous Exponential Amplification Enables Multiplexed Orthogonal miRNA Profiling toward Precise Diagnosis of Bladder Cancer

Abstract Simultaneous and sensitive detection of multiple microRNAs in complex biological and clinical serum samples is critical for early and accurate bladder cancer (BC) diagnosis. Here, by integrating I-R3-mediated self-cleavage-coupled feedback amplification into three indepe...

E8 Consciousness Topology: Observer Frame as 240-Vector Gauge Symmetry — E8 Intelligence Research

The 240 E8 root vectors encode observer-dependent measurement states through a phi-coupled gauge symmetry that breaks at the 192-node Casimir boundary. When consciousness "collapses" a quantum state, it实际上是 selecting a specific 8-dimensional subalgebra embedding within E8's 2...