Research works

Phenolic Profiling and OECD-Guided Acute and Subacute Oral Toxicity Assessment of Cannabis sativa L. Seed Hydroethanolic Extract

Cannabis sativa L. seeds have been traditionally used in Moroccan folk medicine and are increasingly recognized as a valuable source of nutrients and bioactive phytochemicals with promising therapeutic properties. Despite their widespread traditional and nutritional use, scientif...

Strengthening pharmacovigilance systems through Africa-Europe collaboration: Insights from a regulatory roundtable discussion

Background Many African countries have established national pharmacovigilance (PV) centers under their medicines regulatory authorities, but multiple barriers still limit system performance. Comprehensive, well-enforced PV regulations are often lacking, and the reporting culture...

Starbucks and the AI inventory rollback: Computer vision failure and IT governance in physical retail

This teaching case examines the nine-month deployment and eventual discontinuation of Automated Counting, an AI-powered computer vision inventory management system developed in collaboration with Redmond, Washington-based firm NomadGo. One of the most prominent enterprise AI roll...

An Explainable Deep Learning Framework for Musculoskeletal Abnormality Detection

Accurate detection of musculoskeletal abnormalities from radiographs remains challenging because abnormal findings can be subtle and radiographic appearance may vary considerably across examinations. This study aimed to develop and systematically evaluate a deep learning framewor...

Research on Current Fixed-Point Excitation Detection Method for Internal Defects in Prebaked Anode Carbon Blocks

Internal defects such as cracks and pores in prebaked anodes severely affect aluminum electrolysis efficiency and energy consumption. Existing detection methods face an irreconcilable contradiction among speed, cost, and accuracy. To address this issue, this paper proposes a curr...

Trial-related informational needs and decision-making in the SMA community after broad treatment access: results of the 2nd Cure SMA clinical trial experience survey

Abstract Background When clinical trials were the only avenue for people with spinal muscular atrophy (SMA) to access potentially effective disease-modifying therapies (DMTs), people often traveled long distances for trials and were willing to tolerate significant treatment-relat...

Genetic analysis of sensitivity of Bonga and Menz sheep to climate variation under tropical conditions

Purpose This study aims to investigate the genetic background of performance sensitivity to climate variation in Bonga and Menz sheep, with the goal of improving the efficiency and sustainability of sheep production under variable climate conditions. Design/methodology/approach T...

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Numerical Phase Construction in the OFT-Derived VGM Sector: Constraint-Preserving Continuation, Certified Branch Tracking, and Reproducible Atlas Generation

This paper develops a systematic numerical framework for constructing, tracking, and certifying physically admissible phase structures within the Organizational Field Theory (OFT)-derived Vectorial Gravitational Model (VGM). Building upon the preceding effective-field-theory desc...

The Evolution of Disability Sport Policy in Hong Kong: From Welfare to Rights?

This article examines the evolution of disability sport policy in Hong Kong, interrogating how a policy domain rooted in colonial rehabilitation medicine has been reshaped by rights discourse and elite performance imperatives. Drawing on a qualitative documentary analysis of poli...

NEUTRINOS, ASYMMETRY AND EQUILIBRIUM

DESCRIPTION Neutrinos, Asymmetry and Equilibrium: The Choice of One Side and the Transduction of Potency into Act presents a theoretical framework for investigating asymmetry as a directional factor in the transformation of physical and biological systems. The central proposition...

Netherlands Code of Scientific Integrity for Students

The slides to this very activating seminar illustrates how groups of 2-4 students think, pair and share their ideas on how the 5 integrity principles (Scrupulousness (Zorgvuldigheid); Independence (Onafhankelijkheid); Accountability (Verantwoordelijkheid); Honesty (Eerlijkheid);...

Pick Aggregator: A Multimodel Ensemble of Machine Learning Pickers to Generate an Onshore–Offshore Seismic Catalog for Puerto Rico and the Virgin Islands

Abstract Offshore seismic swarms north of Puerto Rico and the Virgin Islands remain poorly characterized due to limited azimuthal coverage from the inland Puerto Rico Seismic Network (network code PR). Here, we integrate data from six U.S. Geological Survey (USGS) ocean-bottom se...

Synergistic Insecticidal Efficacy of the Natural Fumigant Methyl Benzoate Against Phosphine-Resistant Sitophilus oryzae

The widespread emergence of phosphine-resistant populations of stored-product pests, such as the rice weevil (Sitophilus oryzae), poses a significant challenge to effective grain protection. This study investigated the fumigation toxicity of methyl benzoate (MBe), an eco-friendly...

Geriatric Assessment–Based Stratification to Evaluate Treatment Intensity, Quality of Life, and Survival in Older Patients With Metastatic Colorectal Cancer: Protocol for a Prospective Observational Study

BACKGROUND Older patients with metastatic colorectal cancer (mCRC) are a heterogeneous population with wide variability in functional status, frailty, cognition, nutritional reserve, and comorbidity burden. Treatment decisions are often guided primarily by chronological age and p...

Broad multiplex respiratory panel implementation and antibiotic prescribing in US emergency and urgent care departments: a staggered-adoption study

Abstract Objective: To evaluate the association between department-level implementation of broad multiplex respiratory pathogen panels and antibacterial prescribing. Design: Retrospective repeated cross-sectional staggered-adoption study with cohort-stacked difference-in-differen...

Does Surgeon Experience Affect Outcomes in Robotic Cholecystectomy for Emergency Biliary Disease? A Statewide Analysis

BACKGROUND: The use of robotic surgery (RS) as an operative technique in emergency general surgery (EGS) is rapidly growing, with a >3-fold increase in RS-EGS operations since 2011. Prior work has utilized payer claims to evaluate outcomes of RS-cholecystectomy in the EGS setting...

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster p...

Ageism and Quality of Life in Older Adults: The Roles of Self-Disgust and Psychological Distress

This study examined psychological correlates of quality of life (QoL) among older adults in a Latin American context, focussing on the roles of ageism, self-disgust, and psychological distress. Hierarchical multiple regression analyses were used to examine the incremental contrib...

Thrombophilic Variants and Clinical Outcomes in Young Ischaemic Stroke Patients Undergoing Mechanical Thrombectomy: A Retrospective Cohort Study

Objective: This study aimed to characterise thrombophilic variants in young patients (≤50 years) undergoing mechanical thrombectomy (MT) for acute ischaemic stroke and to determine their clinical relevance. In addition, outcomes in young patients were compared with those in older...