Research works

Pasture use dynamics and resource potential assessment in the Moiynkum Sand Massif: a statistical and spatial approach

Pasture degradation in arid regions, driven by climate aridisation and grazing pressure, represents a major challenge for the sustainable management of rangeland resources. This study provides a comprehensive assessment of vegetation dynamics and the factors influencing degradati...

Synthetic β-amino acid polymer promoting keratocyte adhesion and corneal regeneration

Corneal damage ranks among the leading causes of visual impairment globally. Given the prevalence of corneal diseases and challenges of donor cornea shortages and immune rejection, there is an urgent need to develop alternative materials for corneal repair. Although decellular co...

Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma

Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...

A deep learning model utilizing H&E-stained images for predicting HER2-low expression in breast cancer

The development and clinical application of novel HER2-targeted antibody-drug conjugates (ADCs) have significantly improved outcomes for breast cancer patients with HER2-low expression. The efficacy of such therapies critically depends on accurate assessment of HER2-low status. H...

Challenges in the clinical learning environment: experiences of final-year nursing students in a tertiary institution in Ghana

Clinical practicum is central to nursing education, yet suboptimal Clinical Learning Environments can hinder competence development and readiness for practice. Evidence from sub-Saharan Africa remains limited, particularly on final-year students approaching transition to practice...

Stress coping strategies as predictors of job fatigue and psychological health among casino employees in Macao SAR (China)

This study investigates the predictive role of stress coping strategies on job fatigue and psychological health among casino employees in Macao, a sector marked by high emotional labor and irregular work schedules. Guided by the Transactional Theory of Stress and Coping and Workp...

“We cannot rely on foreign entities to take care of our health… we need to change our mindset”: immediate impacts of the 2025 U.S. government funding cuts on health in Kenya

In 2024, the United States Government (USG) distributed $730 million of development assistance for health to Kenya, much of which supported HIV care; in early 2025, almost all USG funding was abruptly halted. This study explores the impacts of the funding cuts on uptake of health...

Are oral hygiene behaviors associated with lower stroke risk? A systematic review

This study aims to systematically synthesize observational evidence on the association between oral hygiene behaviors, including tooth brushing, interdental cleaning, dental visits, and professional dental cleaning, and stroke risk in adults. A PRISMA-compliant systematic review...

Goji berry chromoplasts as water-dispersible carotenoid vehicles: characterization and stability assessment under different storage conditions

Chromoplasts are organelles found in plant cells that store carotenoids. Their naturally hydrophilic structure, which accommodates carotenoids, has garnered increasing interest in recent years. However, the structural characteristics of carotenoid-loaded chromoplasts are still no...

Real-world use of dotinurad and one-year prescription presence by kidney function in older adults

Evidence on dotinurad, a selective urate transporter 1 inhibitor, in older adults with reduced kidney function is limited. We conducted a retrospective cohort study using the Japan Medical Data Center elderly claims database from April 2021 to February 2023 to describe real-world...

Dry-land training in developmental competitive swimmers: a systematic review and meta-analysis of comparative effects across three modalities, dose-response patterns, and associations between physical fitness and swimming-specific performance

Dry-land training is an important component of competitive swimming and is used to develop the physical fitness (PF) required for sport-specific training. However, the relative effects of different dry-land training modalities, their dose-response patterns, and associations betwe...

Patterns of electronic cigarette and heated tobacco product use among adults in Lithuania

The use of electronic cigarettes (e-cigarettes) and heated tobacco products (HTPs) is increasing globally. The pattern of dual and poly-use raises concerns about compounding hazards. However, in Lithuania, there is a lack of comprehensive evaluation of use patterns. To characteri...

Construction and validation of a prediction system for postherpetic neuralgia: based on meta-analysis

Postherpetic neuralgia (PHN) is a chronic and intractable pain disorder. Existing PHN prediction systems have limited clinical applicability. A systematic search of the literature was conducted in PubMed, Web of Science, Embase and the Cochrane Library between 1950 and 2025, fina...

Prevalence and risk factors of falls among older adults in the United States: a cross-sectional study

Several studies have examined falls among older adults in the United States; however, studies using recent nationally representative data to evaluate fall prevalence and associated factors in this population are limited. We investigated the current prevalence of falls among older...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Integrated interpretability machine learning and clinlabomics analysis for the risk prediction of hepatocellular carcinoma

This study aimed to develop a hepatocellular carcinoma (HCC) risk prediction model based on clinlabomics and develop an online prediction tool to provide a novel approach for early HCC diagnosis. We retrospectively collected clinical and laboratory data from 1,017 patients (576 H...

EvoX-Boost: a hybrid evolutionary GPU-XGBoost framework for multiclass thyroid disease classification

Timely and correct diagnosis of the thyroid disease is crucial for thyroid metabolic and cardiovascular complications. However, real-world EMR data are multivariable, heterogeneous and multi-class, which makes traditional ML models sensitive to hyperparameter configurations and c...

Bank Systems

We are introducing the Axiomatization Framework of Bank Systems. Some theorems are completed about Housing, and other Assets Management.

Lipopolysaccharide priming confers trained immunity and enhances antiviral defense against Sendai virus via STAT1/2 signaling

Trained immunity, the functional reprogramming of innate immune cells that enhances responses to secondary challenges, represents a paradigm shift in our understanding of immune memory. We investigated whether lipopolysaccharide (LPS) priming could induce trained immunity against...

A multimodal deep learning framework for real-time burnout detection and personalized intervention in foreign language teachers

Teacher burnout poses significant challenges to educational quality, with foreign language instructors facing distinctive stressors including cross-cultural mediation demands and language anxiety transmission. This study proposes a multimodal deep learning framework for real-time...