Research works

Anaphylactic reaction to the second dose of dacarbazine following initial exposure in patient with hodgkin lymphoma

IntroductionDacarbazine is generally well-tolerated, apart from its hematologic toxicities; however, rare and life-threatening anaphylactic reactions have been reported. We aimed to describe a rare case of anaphylactic reaction to dacarbazine following a previously tolerated firs...

Coexisting Volatile and Nonvolatile Switching in 3D ALD‐IGZO Vertical RRAM for Fully Hardware‐Based Wide Reservoir Computing

ABSTRACT Although indium‐gallium‐zinc oxide (IGZO) has been widely used in thin‐film transistors (TFTs), its application as an active switching medium in resistive random‐access memory (RRAM) has remained relatively less explored, particularly for vertical RRAM (VRRAM) architectu...

Association between Pulmonary Vascular Obstruction Phenotype and Pulmonary Embolism Recurrence: Results from the PADIS-PE Study

Pulmonary vascular obstruction index (PVOI), assessed using the Qanadli index on computed tomography pulmonary angiography (CTPA) at pulmonary embolism (PE) diagnostic, has been associated with recurrence after unprovoked PE, but its complexity limits routine use. We aimed to eva...

Generative AI and the Redistribution of Epistemic Power - From Institutional Dependence to Individual Truth-Testing Capacity

Generative artificial intelligence is commonly discussed as a technology for text production, information retrieval, automation, and decision support. This article proposes a broader interpretation: generative AI may contribute to a redistribution of epistemic power. The ability...

Putnam Exam Solutions: 2000 & 2018 A1 with Number Theory Insights — E8 Intelligence Research

FINDING: Putnam exam unsolved problems overview and specific problem solutions (2000, 2018 A1) with elegant number theory and combinatorial insights. | MATH: No explicit equations or constants extracted from summaries; problem statements not provided. | CONNECTION: No geometric r...

Seasonally Adaptive Natural Ventilation for Sustainable and Energy-Efficient Large-Space Railway Stations in Hot-Summer and Cold-Winter Regions: A Case Study of Chengdu Station

The rapid expansion of high-speed railway networks has increased the operational energy demand and indoor overheating risk of large-scale, high-volume railway station buildings. Natural ventilation is a climate-responsive passive strategy that can improve indoor environmental qua...

Approach to Chronic Pelvic Pain for the Colorectal Surgeon

Thirty-five-year-old female presents with a history of chronic constipation, gastroparesis, chronic lower abdominal pain, and anxiety. She is diagnosed with colonic inertia and undergoes a total abdominal colectomy with ileorectal anastomosis. She initially does well with resolut...

Optimized Extraction of Beneficial Fatty Acid from Fresh Water Algae

AbstractAlgae is a promising source of beneficial fatty acids like triacylglycerols (TAGS), polyunsaturated fattyacids (PUFAS) such as omega 3 fatty acids, omega 9 fatty acids, oleic acid, DHA, EHA, linoleic acid and palmitic acidoffering significant benefits over conventional fi...

Finite-Observation Conditional Guarded Language Operators: Kannan Contractions Beyond Banach Contractivity

We introduce finite-observation conditional guarded language operators on the complete length-based ultrametric space of formal languages over a finite alphabet. A finite observation map selects a guarded branch according to the membership of prescribed test words. Although each...

Integrating field observations and rearing experiments reveals limited temperature sensitiveness of sex determination in the bearded silverside Atherion elymus

Abstract Water temperature is a key environmental factor shaping sex determination in many gonochoristic fishes, with direct consequences for population responses to climate warming. This study is the first examination of temperature effects on sex determination in an atherionid...

LAB #922 HARMFUL: VIDEO SCOUT: Why Trading Strategy Optimization No Longer Works (Do This Instead) — E8 Intelligence Research

IDEA: AUTO VIDEO SCOUT — evaluate this trading strategy video for the swarm: VIDEO: "Why Trading Strategy Optimization No Longer Works (Do This Instead)" by Algo Trading With Kevin Davey — https://www.youtube.com/watch?v=ZYmxCzwNsSU (duration 558s, 2242 views; found via search 'K...

Gamma-Irradiation-EnhancedReduction of 99Tc(VII) and Re(VII) by Natural Pyrite

Abstract Reductive immobilization of 99Tc(VII) to sparingly soluble TcO2-type phases is a key process limiting 99Tc transport in the environment. However, the reactivity of natural pyrite toward 99Tc(VII) under conditions relevant to nuclear waste repositories remains poorly unde...

Artificial PhotosyntheticHydrogel Microspheres asa Versatile Platform for Programmable CO2 Valorization

Abstract Carbon-negative biomanufacturing is essential for global sustainability. Artificial photosynthesis based on material-microbe hybrid systems holds promise but suffers from inefficient energy supply, phototoxicity, abiotic–biotic incompatibility, and limited product spectr...

Genome sequence of the endophytic biocontrol and plant growth-promoting Serratia marcescens strain Sm25P5 from wheat seed

ABSTRACT We report the whole genome of Serratia marcescens strain Sm25P5, an endophyte isolated from blast-resistant wheat seed. The 5.1-Mb genome harbors diverse putative biosynthetic gene associated with nutrient accumulation, mobilization, and antifungal activity, supporting i...

Laser-Induced Graphene Electrochemical Sensors for Rapid and Portable Environmental Pollutant Detection

Environmental pollution is a major global challenge that adversely affects human health, biodiversity, and ecosystems. In this regard, the development of portable and wearable sensing technologies has become increasingly important for real-time, on-site monitoring of environmenta...

Liver-directed gene therapy results in amelioration of progressive familial intrahepatic cholestasis type 2 in mice

Background: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare disease affecting the ABCB11 gene, encoding the bile salt export pump (BSEP). BSEP dysfunction impairs bile acid (BA) secretion, causing hepatic damage and leading to pruritus, cholestasis, hepatom...

Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development

Abstract Maternal immune activation (MIA) disrupts brain development and increases the risk of neurodevelopmental disorders, yet the mechanisms by which MIA impacts human cortical development remain poorly understood. Here we introduce a three-dimensional ex vivo culture system,...

Deciphering the Roleof Hydrophobic Amino Acid l -Methionine in Tuning CO2 Hydrate Kinetics:Insights from Molecular Dynamics Simulations

Abstract CO2 clathrate hydrate has emerged as a promising medium for carbon sequestration owing to its exceptionally high CO2 storage capacity and intrinsic stability in subsea environments. Sluggish growth kinetics hinder its field application and large-scale deployment. The hyd...

Fine mapping and candidate gene analysis of qKnps-2A for kernel number per spike in wheat

Abstract Background Kernel number per spike (KNPS) is a crucial determinant of wheat yield. Previous studies identified qKnps-2A as a major stable QTL for KNPS on chromosome 2A using a recombinant inbred line (RIL) population derived from a cross between the semi-winter wheat cul...

The Influence of Spatial Location and Object Shape on Learning and Re-Learning Spatial Tasks in Dopamine Transporter-Deficient Rats

Background: The role of dopamine in brain functions has been well established, and dopamine imbalances can cause problems in working memory and spatial learning. The dopamine transporter (DAT) plays a significant role in dopamine regulation. Rats with a knockout of the dopamine t...