Research works

Exploring the New Trial Data Protection Regime in China

Premarket clinical trials demand substantial investment, yet without data protection, generic applicants could rely on originator data to obtain approval, undermining innovation incentives. In May 2026, China’s National Medical Products Administration issued the Implementation Me...

Association of Diagnosis Age with Clinical Characteristics and MRI Findings in Multiple Sclerosis

Background: Age at multiple sclerosis (MS) diagnosis may be associated with clinical course, inflammatory activity, and disability accrual, but evidence across the full age spectrum remains limited. We compared clinical and radiological features, phenotype distribution, and time...

The Effect of Coarse-Grained and Ultrafine-Grained Ti13Nb13Zr Alloy Substrates on the Structure and Properties of Calcium Phosphate Coatings Formed by Micro-Arc Oxidation

This study investigates the formation, structure, phase composition, and performance of oxide–phosphate coatings produced by micro-arc oxidation (MAO) on coarse-grained and ultrafine-grained Ti13Nb13Zr alloy substrates. The effects of MAO treatment conditions and substrate struct...

TIBBIYOT OLIY TA'LIM MUASSASALARI TALABALARINING HARBIY XIZMATGA TAYYORGARLIGINI TA'MINLASHDA KASBIY-AMALIY JISMONIY TAYYORGARLIKNING O'RNI VA AHAMIYATI

Mazkur maqolada tibbiyot oliy ta'lim muassasalari talabalarini harbiy xizmatga tayyorlash jarayonida kasbiy-amaliy jismoniy tayyorgarlikning o'rni va ahamiyati tahlil qilinadi. Harbiy-tibbiy faoliyatni amalga oshirishda zarur bo'lgan jismoniy sifatlar, funksional imkoniyatlar, ps...

Diabetic Peripheral Neuropathy: Implementing Guidelines into Practice

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, affecting up to 50% of patients. Early identification and management of DPN are crucial to minimize complications and maintain patient quality of life. Multiple guidelines have been develo...

The glymphatic–lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration

Abstract The discovery of the glymphatic system and meningeal lymphatic vessels has transformed our understanding of brain fluid homeostasis and central–peripheral communication, highlighting the critical role of cerebrospinal fluid in brain clearance. While substantial progress...

Strengthening non-communicable disease health systems through sustainable health partnerships in the Horn of Africa using lessons from the Wolverhampton–Somaliland Global Health Partnership

Non-communicable diseases (NCDs) are rapidly emerging as major causes of morbidity and mortality across the Horn of Africa, compounding persistent infectious diseases, humanitarian crises and fragile health systems. This Perspective examines how sustainable, nationally led health...

Impact of Capital Adequancy Ratio on Return on Equity

This study investigated the effect of the Capital Adequacy Ratio (CAR) on the Return on Equity (ROE) of quoted deposit money banks in Nigeria, while controlling for firm size and leverage. A quantitative research design was employed using secondary panel data obtained from the au...

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from cor...

Asymmetric Autonomy and the Collapse of Passive Defense: A Systems-Theoretic Critique of AI-Driven Cyber Saturation Attacks and Institutional Negligence in Critical Infrastructure

【Abstract】This strategic systems monograph formulates a comprehensive critique of the catastrophic failure mode observed in passive cyber defense architectures under the onslaught of advanced, autonomous AI-driven saturation attacks. By analyzing the wave of massive, indiscrimi...

WTC-CNXGRN: An Operational Wind Turbine Clutter Detection Model for Dual-Polarization Radar Under Complex Weather

Wind turbine clutter (WTC) can severely degrade the quality of meteorological radar data, particularly under complex weather conditions. Because WTC echoes can substantially overlap with precipitation echoes, they may introduce considerable errors into weather identification and...

Polysaccharide Reengineering: Strategic Modifications and Biofunctional Outcomes of Natural Polysaccharides

Natural polysaccharides have attracted considerable interest in pharmaceutical and biomedical applications. However, native polysaccharides often possess limitations, like poor solubility, inadequate mechanical strength, limited stability, and insufficient control over their func...

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise co...

Data governance, business strategy, and sustainability practices: exploratory employee-perception evidence from a single pulp and paper corporate group

Purpose This study examines how data governance (DG) contributes to environmental, social, and governance (ESG) integration by strengthening data accountability, the reliability of ESG-related information, and strategic alignment. Grounded in the resource-based view (RBV), it inv...

Big Data Governance and Financial Support

Abstract A framework and a set of indicators developed for monitoring the management system and financing mechanisms for working with big data are presented. The framework includes two components covering the very management system for the development and the use of big data tech...

Genetic and Epigenetic Diversity of Salmonella enterica Isolates from Clinical and Veterinary Sources in Kazakhstan

Salmonella enterica is a major cause of foodborne and invasive infections worldwide. This retrospective study used whole-genome sequencing to compare the genotypes and characterize the genomic diversity of bacterial strains preserved in an archived culture collection, originating...

Who Carries the Party on Facebook? Leaders, Party Pages and the Polls in Britain, 2010 to 2020

Is a British party's Facebook audience built around its leader or its party page, and does either track the polls? I use 89,110 posts from the pages of eight parties and eighteen of their leaders between June 2010 and October 2020, which drew 218 million interactions, and match t...

When Co-Branding breaks down: strategic misalignment, symbolic rupture, and consumer resistance

Purpose This study aims to examine how and under what conditions co-branding in collaboration-saturated markets is associated with negative consumer responses. Moving beyond fit- and synergy-based explanations, it theorizes consumer negative agency (CNA) as agentic, tactic-focuse...

Gram-Positive Bacteria Responses to Antibiotics When Incubated in Fecal in Vitro Microcosms from Swine Supplemented with Chlorophyllin

Standardized antimicrobial susceptibility assays use defined culture media and may therefore not fully account for gastrointestinal constituents that influence bacterial responses to antibiotics. This study evaluated whether swine fecal extracts, including extracts associated wit...

Upregulation of cellular exhaustion-related genes and CD4 + T cell disturbances in immunological non-responders on antiretroviral therapy

Abstract Antiretroviral therapy suppresses HIV replication, but 10–40% of people living with HIV do not reconstitute CD4 + T cell counts despite viral suppression. Cellular exhaustion and alteration in the frequency of CD4 + T cell subsets are mechanisms involved in immunological...