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A new material was accidentally created on a space station

An intermetallic compound formed as a byproduct of microgravity experiments has been recreated and studied on Earth.

Hyaluronic acid nanoparticle as drug delivery carrier for the treatment of allergic conjunctivitis

Background Allergic conjunctivitis is an inflammatory disorder of the conjunctiva triggered by allergens. Although topical eye drops are widely used, their efficacy is limited by rapid precorneal clearance and low ocular bioavailability. Hyaluronic acid (HA)-based nanoparticles m...

Pipeline Dreams: The STEMM Aspirations of High School Girls in Delhi

The article traces the evolution of interests, choices and goals of high school girls in Delhi, India, as they pursue academic aspirations in Science, Technology, Engineering, Mathematics and Medicine (STEMM). It aims to understand the complex ways in which girls’ aspirations are...

High‐Responsivity and Fast‐Response Organic Phototransistor Based on Dinaphtho[2,3‐b:2′,3′‐f]Thieno[3,2‐b]Thiophene

ABSTRACT Organic phototransistors (OPTs) are promising as low‐cost detectors compatible with plastic‐substrate electronics for visible light communication (VLC) systems. However, enhancing their sensitivity without sacrificing speed remains challenging. In this work, we report on...

Atrial Flutter Secondary to Severe Laxative-Induced Hypomagnesemia in Anorexia Nervosa: A Case Report

Atrial flutter is an uncommon supraventricular arrhythmia in young adults without structural heart disease and is typically associated with underlying cardiac pathology rather than isolated metabolic abnormalities. Electrolyte disturbances, particularly hypomagnesemia, can contri...

Pyrroloquinoline Quinone and NAD+ Metabolism in Glaucoma: A Molecular Rationale for Combined Neuroprotection

Glaucoma is the leading cause of irreversible blindness worldwide and a paradigmatic age-related neurodegenerative disease in which retinal ganglion cells (RGCs) are selectively lost through mechanisms that extend beyond intraocular pressure. Age-dependent NAD+ depletion in RGCs,...

Full Plate Living Evaluation and Case Series

Dietary interventions can improve cardiometabolic health, however, affordability, sustainability, and efficacy remain a challenge. Full Plate Living (FPL) is a free, virtual, research-based, experience-centered nutrition program that has been shown to improve health. Here, we des...

A Pan-Cancer Target Trial Emulation of Exercise and Distant Disease-Free Recurrence

BACKGROUND: We leveraged observational data to conduct a target trial emulation (TTE) framework evaluating the association of exercise on distant disease-free survival (DDFS) in a pan-cancer cohort. METHODS: To emulate a randomized controlled trial (RCT), a "historical" exercise...

Quantum Fractal Dynamics from Complex Relativistic Kinematics

We establish an exact mathematical isomorphism mapping special relativistic kinematics in complex velocity space directly to microscopic quantum fractal trajectories ($\Delta x \sim \sqrt{\Delta t}$) and local spacetime geometry. Guided by the principle that scale transformations...

Mechanism and Application of Biochar as an Electron Shuttle in the Remediation of Soil Pollutants

Biochar has attracted increasing attention in soil remediation due to its porous structure, abundant surface functional groups, and environmental compatibility. Beyond its conventional roles as an adsorbent and soil amendment, biochar has increasingly been recognized as an electr...

Association between cardiometabolic index and incident electrocardiographic abnormalities in older adults

Electrocardiographic (ECG) abnormalities are important predictors of cardiovascular events in older adults, yet their early identification remains challenging. The cardiometabolic index (CMI), which integrates central obesity and lipid metabolism, has emerged as a potential marke...

CMV PCR Monitoring for Hematological Malignancy

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Health-Related Quality of Life of Patients with Epidermolysis bullosa and Carers Using a Time Trade-Off Approach in the UK General Population to Elicit Utilities for Health Technology Assessment

Background: Epidermolysis bullosa (EB) is a complex group of rare, inherited skin disorders that blister easily, imposing substantial burden on patients and carers. There is a lack of published evidence in the UK quantifying health-related quality of life in EB patients and carer...

Fuzzy Congruences on Heyting Algebras: Characterizations via Fuzzy Ideals and Filters.

<ns5:p>Background Heyting algebras serve as algebraic models for intuitionistic logic, with classical congruence relations playing a key role in their structural analysis. This paper extends classical congruence theory to the fuzzy setting, motivated by the need to handle gradati...

Axiomatic System and Core Constants of Discrete Variable Lattice Dissipative Functionals Well-Posedness Proof of Discrete Dissipative Helmholtz Problem on Finite Hierarchical Fractal Lattice

Abstract This paper constructs an axiomatic mathematical framework for discrete variable lattice dissipative functionals. Utilizing four mutually independent fundamental axioms as a minimal complete basis, it systematically investigates the operator properties, steady-state struc...

RETHINKING DEMOCRATIC GOVERNANCE AND INCLUSION OF LOCAL GGOVERNMENT IN POLITICS IN NIGERIA

Democracy has been observed as the only acceptable way of enhancing governance in all countries of the world, including Nigeria. The idea of democracy permits or allows for the majority participation or inclusion of localities in governance and guarantees the strict adherence to...

On Leonardo’ choice to depict a wingless blister beetle producing a sexual stimulant

A largely overlooked drawing of a blister beetle belonging to the genus Meloe made by Leonardo da Vinci is discussed. An array of hypotheses about the reasons for portraying such an insect are briefly put forward, including that of an interest for the beetle as an aphrodisiac.

HIV Pre-Exposure Prophylaxis Use Among South Asian Sexual Minority Men in the United States: Pilot Web-Based Survey Study

Abstract Background South Asian American gay, bisexual, and other men who have sex with men (GBM) experience multiple minority stressors, such as internalized homophobia, racial prejudice, and homonegative discrimination, thereby elevating their risk of HIV. Due to the scarcity o...

EuroMillions Breakthrough Mining — 1693 Sources, 12432 Leads Extracted — E8 Intelligence Research

Mined 1693 lottery+quantum breakthroughs. Extracted 12432 leads across 13 categories. 10446 high-value leads found. Categories: {"CORRIDOR": 1032, "FORMULA": 876, "GEOMETRIC": 718, "FORWARD_ATTEMPT": 1081, "QUANTUM": 1294, "TIMING": 204, "CELESTIAL": 960, "GEMATRIA": 1028, "CONST...

Quartz Optimizer: Robust Gradient Shaping and Bounded Adaptive Steps for Stable Deep Learning Training

Optimization plays a critical role in training deep neural networks, directly impacting convergence speed, model generalization, and stability. While existing methods such as stochastic gradient descent (SGD) and adaptive optimizers like Adam and AdamW have achieved significant s...