Research works

Peripheral CD4 + T‐Cell Reserve as a Potential Biomarker of CD20 × CD3 Bispecific Antibody Outcomes and BTK Inhibitor–Associated Immune Modulation in B‐Cell Lymphoma

ABSTRACT Bispecific antibodies (BsAbs) targeting CD20 × CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B‐cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. We retrospectively evaluated associations between peri...

Transportation Use, Trip Taking, and Trip Purposes Among Older Adults Not in the Labor Force: Evidence From the 2022 National Household Travel Survey

Background Transportation needs may differ by labor-force participation status, yet little is known about travel behavior among older adults not in the labor force. Objective To examine alternative transportation use, trip taking, and trip purposes among older adults not in the l...

Explicit-implicit symbiosis: narrative logic of urban industrial heritage landscapes

As a material carrier of industrial civilization and collective memory, industrial heritage constitutes an important component of human cultural heritage and a key object for maintaining urban context and reconstructing social identity. The protection and regeneration of urban in...

From Hesitancy to Healing: Mental Health Discussions in Hair Care Settings as Pathways to Self-Care Among Black First-Year College Students

The present study examined whether hesitancy to seek professional mental health services was associated with mental health discussion with hairstylists or barbers and whether these discussions were associated with various forms of self-care among Black first-year college students...

BACTERIAL TYPES CAUSING RESPIRATORY INFECTIONS IN OIL REFINERY

Background: Chronic bronchitis typically occurs in individuals with contributing factors such as smoking or environmental exposure to dust, which results in decreased mucus production and ciliary function. Although the role of bacterial infection in chronic bronchitis is unclear....

Spatial multi-omics uncovers an invasive-desmoplastic cellular community with prognostic and therapeutic implications in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense desmoplastic stroma and profound spatial heterogeneity, yet the multicellular organizational principles governing its tumor microenvironment remain poorly understood. Here, we performed single-cell RNA s...

Insights into the role of chemical composition on the precipitation kinetics and properties of L12-strengthened Cu–Ni–Al alloys: A thermodynamic-driven phase field kinetics simulation

Cu–Ni–Al alloys represent a novel class of L1 2 -strengthened Cu-based alloy, offering enhanced thermal stability and high temperature mechanical properties. However, the influence of chemical composition on the precipitation kinetics of the L1 2 phase remains insufficiently unde...

“My Existence is Queer”: Understanding Trans and Nonbinary College Students’ Sexual Identities

Scientific practices surrounding sexual identity are largely based upon cisheteronormative assumptions, using terms that may not resonate with − or may exclude − trans and nonbinary (TNB) individuals and their experiences. This exploratory study examined how TNB college students...

SARS-CoV-2-Specific IgG Levels Are Inversely Associated with ACPA-Reactive Pathological and Natural Autoantibody Profiles in Residual Diagnostic Samples

Background/Objectives: SARS-CoV-2-specific antibody levels vary among patients with systemic autoimmune rheumatic diseases (SARDs). In rheumatoid arthritis (RA), the most prevalent SARD, this is further shaped by rheumatoid factors (RFs). Attenuated post-vaccination antibody leve...

Mass Spectrometry-Based Omics: An Integrated Framework for Analytical Quality, Data Integrity, and Biological Interpretation

Results obtained with mass spectrometry-based omics depend on every stage of the work, from sample collection to data processing. Quality guidance exists for individual omics fields and for individual stages, but it rarely states when a dataset is ready for statistical analysis o...

Exploring Human Coach Distinctiveness in an Age of AI: An Interpretative Phenomenological Analysis of the Roles of Values

Objective: This study examined how professional coaches understand the role of values in their practice and why they see these as central to what human coaches offer compared with AI coaching agents. Method: Interpretative phenomenological analysis was used with semi-structured i...

Agentic Architecture of Information Systems — The AAM/5C Model: A Reference Model for Distributed Autonomy

The technical leadership of large organizations faces what the book calls the cognitive complexity wall: at the scale of hundreds of interacting components, maintaining an Information System's dependency map and reacting at the pace of incidents increasingly exceed what a human t...

Advancing Compliance in Nigeria's Public Procurement through Technology, Data Analytics and Regulatory Frameworks

Public procurement in Nigeria is plagued by inefficiency, corruption, and weak enforcement despite the Public Procurement Act of 2007. This study assesses the integration of technology, the impact of data analytics on risk detection, and the role of regulatory agencies in advanci...

Effective Change Management and Its Role in Facilitating Time-Driven Activity-Based Costing Adoption in Malaysian Private Universities

This study investigates the role of Effective Change Management (ECM) in facilitating the adoption of Time-Driven Activity-Based Costing (TDABC) in Malaysian private universities. Grounded in Organizational Change Theory and innovation adoption literature, the study conceptualize...

Shaping power and strategic security framing: China’s Global Security Initiative in Africa, the development–security nexus, and the case of Ethiopia

This article examines widely overlooked shifts in China’s interactions with African states resulting from the all-encompassing securitization of politics under Xi Jinping. It argues that Beijing seeks to increase China’s discursive and shaping power capacities through strategic s...

Visual Perception and Autonomous Navigation Control for Orchard Robots: From Scene Understanding to Closed-Loop Motion Execution

Autonomous navigation is essential for orchard robots performing spraying, weeding, inspection, harvesting, and transport, yet semi-structured orchards combine repeatable tree-row geometry with canopy occlusion, uneven illumination, weak road boundaries, terrain variation, and in...

Lattice Gauge Theory: Discretizing Spacetime for Non-Perturbative QCD Calculations — E8 Intelligence Research

FINDING: Lattice gauge theory provides a discrete, computationally tractable formulation of quantum field theories (e.g., QCD) by discretizing spacetime onto a hypercubic lattice, enabling non-perturbative calculations of particle masses and gauge field dynamics. | MATH: Wilson a...

Targeting EGR1 Attenuates CCL2 Expression in Inflammatory Keratinocytes and Allergic Skin Inflammation

Early growth response 1 (EGR1) is a zinc-finger transcription factor involved in inflammatory gene regulation, but the extent to which pharmacological inhibition of EGR1 DNA-binding activity influences inflammatory transcriptional responses in keratinocytes remains incompletely u...

The Silent Spaces of Cultural Heritage: The Transformation of Archaeological Excavation Houses

With the development of the discipline of archaeology, excavation houses emerged initially as temporary shelter solutions; over time, however, the extension of excavation periods, the diversification of working conditions, and the increase in interdisciplinary studies led them to...

E8 Phi‑Resonance Stabilizes Asymmetric Posner Clusters — E8 Intelligence Research

The 240 root vectors of the E8 lattice, when driven at the base frequency of 132 Hz and modulated by the golden ratio (φ), generate a quasi‑periodic pressure wave that compensates for the intrinsic symmetry breaking of the Posner molecule's Ca₉(PO₄)₆ ensemble. This φ‑coupled E8 r...