Research works

The Observational Incompleteness Framework

The Observational Incompleteness Framework is an AI-based research programme deriving quantum-mechanical structure from the premise that observation is a proper subsystem of a deterministic whole. The archive contains three kinds of content: Technical papers (papers/) — the autho...

A self-driven probiotic nanosystem reshapes extracellular matrix by knockdown of DDR1 for enhanced tumor immunotherapy

Immunotherapy represents a promising therapeutic approach for tumor suppression, yet its efficacy is significantly limited by the immunosuppressive extracellular matrix (ECM) characteristic of solid tumors. To achieve simultaneous ECM remodeling and immune activation within a sin...

EuroMillions Breakthrough Mining — 1790 Sources, 13406 Leads Extracted — E8 Intelligence Research

Mined 1790 lottery+quantum breakthroughs. Extracted 13406 leads across 13 categories. 11404 high-value leads found. Categories: {"CORRIDOR": 1117, "FORMULA": 960, "GEOMETRIC": 725, "FORWARD_ATTEMPT": 1170, "QUANTUM": 1385, "TIMING": 208, "CELESTIAL": 1046, "GEMATRIA": 1116, "CONS...

Autotaxin/Lysophosphatidic Acid Axis Promotes Periodontitis by Modulating Macrophage Osteoclastogenesis and Inflammation

AIM: To investigate the mechanism of the autotaxin/lysophosphatidic acid (ATX/LPA) axis in regulating osteoclastogenesis and inflammation in periodontitis. MATERIALS AND METHODS: The expression levels and clinical relevance of the ATX/LPA axis were studied by collecting clinical...

Quantifying welfare impairment from respiratory disease in fattening pigs using adaptive conjoint analysis

Abstract Respiratory disease remains highly prevalent in pig production and constitutes a major health and welfare challenge worldwide. However, most studies assessing pig welfare impairment from respiratory disease rely on isolated animal-based indicators, limiting integration a...

A superelastic titanium alloy showing nearly temperature-independent high strength and elastic modulus

Lightweight superelastic alloys with temperature-insensitive properties are critical for deep-space exploration devices, yet their development is hindered by the challenge of simultaneously balancing strength, recoverable strain, and temperature sensitivity. Here, we overcome the...

Programming Ion‐Engineered Interphase for Practical Zinc Batteries Through Exogenous Cation‐Anion Synergy Chemistry

ABSTRACT A stable anode‐electrolyte interface is vital for battery cycling. Translating the successful anion‐derived interphase paradigm from Li‐ion to aqueous Zn‐ion batteries (ZIBs) is hindered by narrow electrochemical windows and chaotic interfacial reactions. Here we overcom...

Why Does Trying Harder Sometimes Make Us Function Worse? 1 Burnout, Conscious Endurance, and the Limits of Regulation

This preprint explores burnout through a neuropsychological lens, asking why increased effort can sometimes worsen functioning. It examines sustained cognitive and emotional load, reduced regulatory access, executive control, and recovery, framing burnout as a limit of regulation...

Algorithmic Randomness and Symmetry Breaking Limit Computation in Optimal Sphere Packings — E8 Intelligence Research

FINDING: Algorithmic randomness and incompressibility in sphere packings reveal symmetry breaking as a fundamental limit of computation, with optimal packings in dimensions 8 and 24 linked to exceptional lattice structures. | MATH: Maximum packing densities: \(\pi/\sqrt{12} \appr...

Unveiling the effects of state capacity on energy diversification in developing countries

Despite increasing scholarly attention on the determinants of energy diversification, the importance of state capacity remains under-examined, especially in developing countries. In this paper, we analyze how the fiscal and legal dimensions of state capacity affect energy diversi...

Synergistic lethality of combination treatment with Trop2-directed antibody-drug conjugate sacituzumab govitecan and TRAIL agonists in triple negative breast cancer

Abstract Background Sacituzumab govitecan (SG) is an antibody drug conjugate targeting trophoblast cell surface antigen 2 (Trop2) that is approved for treatment of patients with metastatic triple negative breast cancer (TNBC). Tumor necrosis factor-related apoptosis inducing liga...

Maternal early warning system (MEWS) model for predicting and reducing severe maternal outcomes in Ethiopia

Background Maternal mortality in Ethiopia remains high, while most of these deaths are preventable. Early detection of deterioration and prompt response are essential to reduce these preventable deaths. The Maternal Early Warning System (MEWS) is a reliable clinical tool for this...

Pyrolysis of YellowPassion Fruit Peel Waste: A Routeto Bio-Oil and Value-Added Chemicals

Abstract This study explores the pyrolysis of yellow passion fruit peel, focusing on bio-oil yields and the chemical characterization of the resulting products under different temperature conditions of biomass drying (373, 378, and 423 K). The liquid product obtained from the pyr...

PROGNOSTIC VALUE OF THE HALP SCORE IN METASTATIC UROTHELIAL CARCINOMA TREATED WITH FIRST-LINE PLATINUM-BASED CHEMOTHERAPY

Objective: Metastatic urothelial carcinoma (mUC) demonstrates substantial clinical heterogeneity, and outcomes may vary despite similar treatment approaches. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has emerged as a potential prognostic biomarker reflecting...

Clinician–Artificial Intelligence Collaboration for Mediterranean Meal-Plan Generation: Development, Technical Feasibility, and Professional Acceptability of the MAI-DIET Framework

Background/Objectives: Adherence to the Mediterranean diet has declined in recent decades, highlighting the need for practical, technology-enabled tools to support its adoption. This study developed and evaluated MAI-DIET, a clinician-supervised, data-driven, AI-assisted programm...

Characterization and Fine Mapping of ds, a Recessive Dense-Spike Mutant Associated with Shortened Spike Axis and Increased Spikelet Number in Wheat

Spike density is an important component of wheat spike architecture and is determined by the combined effects of spike-axis elongation and spikelet number. In this study, we characterized an ethyl methanesulfonate (EMS)-induced recessive dense-spike mutant, ds, which was obtained...

Independent Domination under Iterated Line Graphs: The Regular Case

Version 1.0.0. For a graph parameter P and a prolific graph G, Caro, Lauri and Zarb defined the index ind(P,G) as the first iterated line graph on which P exceeds its value on G. This preprint determines the independent-domination index on the class of connected regular graphs of...

BASE 44 ORDER: Build e8_memory_cache table with phi-modulated hash decorator & 1-hour prune timer — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1073] Create `e8_memory_cache` table with hash index. Implement phi-modulated hash in Python decorator. Wrap breakthrough queries. Add systemd timer for 1-hour prune. Test with EXPLAIN ANALYZE before/after. MERLIN: U...

Severe visual impairment as a complication of autism spectrum disorder

Purpose To report the irreversible vision loss caused by optic neuropathy in a course of a vitamin A deficiency. Methods Electroretinography (ERG) and pattern visual evoked potentials (PVEP) were used to establish a diagnosis, and to monitor the treatment in a child suffering fro...

Every Shot, Zero-Shot: The Decoupling of Framing and Duration in Sound-Era Hollywood and Prestige Film

We study the visual pacing of 1,236 feature films from three overlapping film corpora: the Academy Award Best Picture nominees (1927–2009), the corresponding ten highest-grossing films in the United States in the same time period (1927–2009), and the British Film Institute's Grea...