Research works

Synthesis of Spiro-Bridged 3,4-Dihydrocoumarins Through an Organocatalytic Cascade Sequence Diels–Alder/Nucleophilic Ring Closing

3,4-dihydrocoumarins and spiro compounds constitute an important class of privileged frameworks present in a wide variety of natural and synthetic molecules with diverse applications. In this study, we developed an organocatalytic methodology for the construction of complex and d...

Finality Without Effective Review

Finality Without Effective Review examines the relationship between prosecutorial finality, evidentiary assessment, and effective legal protection under Latvian criminal procedure. The study focuses on the legal consequences of Section 373(7) of the Latvian Criminal Procedure Law...

A practical algorithm for weighted k ‐hulls

Abstract The convex hull is a central concept in computational geometry, geometry processing, and generally for summarizing sampled data. Its descriptive power suffers significantly in the presence of noise. The k‐hull, also known as the k‐depth contour in statistics, is the inte...

A General Approach for Estimating Projective IRT Models

Projective Item Response Theory (PIRT) modeling is a measurement framework in which multidimensional item response models are expressed in terms of lower-dimensional (e.g., unidimensional) proxy IRT models. Existing PIRT methods and their associated estimators currently rely on l...

Variation in glabrous skin physiology across anatomical locations on the human hand

Abstract Skin physiology varies greatly between anatomical locations, with impact on tactile sensitivity. Research on the variations in morphology and physiology between different anatomical locations of glabrous skin is limited so far. This study investigates the morphology and...

Spatio-Temporal Behavior of End-Wall Film Cooling of a Turbine Vane with Purge Flow Measured by Fast-Response Pressure-Sensitive Paint

Abstract The demand for high-efficiency, low-emission gas turbines has intensified with growing global energy consumption. In modern turbines, elevated inlet temperatures and uniform combustor-exit profiles expose the first-stage vane endwall to severe thermal loads. Complex vort...

An Innovative Searching for High-End Making Product Even Equipment &GDP Systems on Scientist's Behaviour and Judgement with Sustainability VII

Abstarct The high-end making, new energy &AI (artificial intelligence) robot will occupy the new reformation field so that the much R &D (research and development) and investment is to be added continually by our government, maker &university. On the other hand, the expertise res...

EcoRestore-KG: A Multi-Agent Framework for Knowledge Graph Construction in Territorial Ecological Restoration

Territorial ecological restoration involves a continuous chain of tasks, including degradation diagnosis, target identification, zoning-based governance, process monitoring, effectiveness assessment and adaptive management. The relevant knowledge is widely distributed across poli...

Application of Proximity-Labeling Techniques in Plants: A Review of Successful Cases

Exploring protein–protein interaction (PPI) networks during cellular processes is critical for understanding the molecular mechanisms underlying these processes. PL (proximity labeling) is an emerging technique with the potential to be a powerful protein interactomics tool. It em...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Barriers and facilitators to implementation of enhanced recovery after surgery protocols in resource-constrained hospitals: A mixed-methods study from a semi-urban government teaching hospital

Introduction: Enhanced recovery after surgery pathways improve postoperative outcomes, yet consistent implementation remains challenging, particularly in resource-constrained settings. Previous observations identified variability in adherence to key enhanced recovery after surger...

Determinants of life expectancy with unmet needs in the Chinese older population (revision 1)

Abstract This study investigates the determinants of and disparities in life expectancy (LE) with unmet long-term care needs among older people in China. The data come from four waves of the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative surv...

Optimal Public Sector Premium, Talent Misallocation, and Aggregate Productivity: Evidence From Egypt

ABSTRACT We develop a tractable general equilibrium model to quantify the long‐run aggregate productivity gains from adjusting the public‐sector premium and the size of the public sector to their productivity‐maximizing levels. The model incorporates an endogenous choice between...

1-Piperidine Propionic Acid Inhibits PAR2/SerpinB3 Signaling and Reduces Glioblastoma Tumor Aggressiveness

Glioblastoma multiforme is the most aggressive primary brain tumor in adults, which displays extremely poor prognosis. Protease-activated receptor 2 (PAR2) and its downstream effector SerpinB3 are overexpressed in aggressive glioblastomas. In this study we evaluated the antitumor...

Changes in deer hunter satisfaction under special antlerless harvest regulations in Pennsylvania, USA

Abstract Management of white‐tailed deer ( Odocoileus virginianus ) to control their consumptive effects on understory forest vegetation has been a long‐standing challenge in Pennsylvania, USA. In 2003, the Pennsylvania Game Commission implemented the Deer Management Assistance P...

BASE 44 ORDER: Build E8-to-trauma insight mapper module for Discovery Lab — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #743] Create a Python module that reads E8 root vector frequencies from the research swarm, maps them to trauma-signature patterns in the knowledge extractor, and outputs novel insight combinations to the Discovery La...

Dreams as Predictive Neural Rendering: Memory Recombination, Internal Simulation, and State-Dependent Testing

This theory-and-methods paper develops a source-faithful Self Aware Networks account of dreams as state-conditioned predictive neural renderings. It separates scene generation, source attribution, vividness, memory recombination, conscious access, and later report; specifies disc...

Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses

Thogotoviruses and quaranjaviruses are arthropod-borne orthomyxoviruses that circulate widely in wildlife and domestic animals and include several zoonotic members. Despite their close phylogenetic relationship to influenza viruses, the mechanisms underlying their replication rem...

Spontaneous emergence of skyrmions beyond room temperature in boron-doped CrTe

Abstract Magnetic skyrmions are vortex-like spin textures that exhibit remarkable emergent phenomena and hold great promise for applications in spintronics, magnonic devices, and neuromorphic computing. Typically, these spin textures are formed in magnetic samples through the app...

A Flood Setback Performance Index to Assess the Pluvial Flood Resilience of School Campuses in a Rapidly Urbanizing Coastal City

Pluvial flooding is intensifying in fast-growing coastal cities as rapid urbanization increases impervious surfaces and reduces natural infiltration, challenging planners to identify scalable and site-level mitigation strategies. Although statutory setbacks around institutional b...