Research works

A nomogram for predicting the risk of incident LDL-C elevation in type 2 diabetes mellitus: development and external validation in a community-based cohort

Dyslipidemia is a major risk factor for cardiovascular complications in patients with type 2 diabetes mellitus (T2DM), and early risk assessment may help inform follow-up and lipid monitoring. This study aimed to develop and externally validate a nomogram based on Cox proportiona...

Thermal stability and CO₂ adsorption–desorption performance of synthetic hectorite and its CeO₂/NiO nanocomposites

Understanding the properties of clay minerals is crucial for developing efficient adsorbent and catalytic materials, creating new options for carbon capture technologies (CCT). This study investigates for the first time the thermal stability of synthetic hectorite (Hec), a smecti...

Genome-wide association analyses reveal genetic loci associated with cold responses in Miscanthus under non-acclimated and cold-acclimated conditions

Miscanthus species are C4 perennial bioenergy crops with broad environmental adaptability, yet episodic freezing events can constrain establishment and productivity. We evaluated cold-response variation in a 144-accession panel comprising 73 M. sacchariflorus and 71 M. lutariorip...

Strategic human resource management and resource value attributes for sustainable manufacturing performance

Human capital is increasingly recognized as a strategic driver of sustainable industrial performance, yet empirical evidence on how valuable, rare, inimitable, and non-substitutable (VRIN) human-resource attributes translate into competitive advantage and sustainable performance...

Watermelon vine as dual-functional additive in ecological porous concrete

Ecological porous concrete (EPC) is constrained by a persistent trade-off: the dense cementitious matrix required for strength reduces porosity and generates a highly alkaline pore environment (pH > 11) inimical to plant growth. To address this, the present study investigates wat...

HLA-DMA depletion suppresses malignant glioma phenotypes and murine H2-DMa knockdown enhances the response to anti-PD-1 therapy

Glioblastoma (GBM) exhibits poor responsiveness to immune checkpoint blockade, largely due to an immunosuppressive tumor immune microenvironment. Tumor-associated macrophage (TAM) polarization critically regulates antitumor immunity, yet the role of human leukocyte antigen class...

Intratumoral microbiota: spatiotemporal dynamics, microenvironmental immune reprogramming, and immunotherapeutic implications

The discovery of intratumoral microbiota has challenged the traditional view of tumors as sterile environments and revealed a previously unrecognized layer of complexity within the tumor microenvironment (TME). Accumulating evidence indicates that microorganisms residing in tumor...

Transcriptomic and lipidomic analysis reveal hepatic metabolic disorders associated with ovarian regression in late-laying ducks

The liver serves as vital metabolic organ that mediates lipid biosynthesis and coordinates systemic lipid metabolism. However, the molecular alterations in hepatic lipid metabolism correlated with ovarian regression in the late-laying ducks are poorly understood. In this study, w...

STAMPformer: spectral-prior-guided multi-view attention learning for hyperspectral prediction of continuous frost damage severity in field-grown tea plants

Frost damage severely constrains the growth, development and quality formation of tea plants, underscoring the need to develop accurate field-scale methods for the assessment of frost damage severity. In this study, hyperspectral data and eight key physicochemical indicators were...

Advancing graphene-enabled piezoelectric, triboelectric, and hybrid nanogenerators: A review on mechanistic and performance optimization

Graphene significantly enhances the performance of piezoelectric (PENG), triboelectric (TENG), and hybrid piezoelectric-triboelectric (H-P/TENG) nanogenerators by regulating polarization, dielectric behavior, charge transport, and interfacial coupling. This review presents a crit...

Aberrant lipid metabolic reprogramming accelerates gastric cancer malignancy through diminished ceramide-driven ALPP inhibition

Metabolic reprogramming is a canonical hallmark of cancer that reflects the biological properties of tumors. Deciphering the metabolic profiles and key metabolites involved in tumor progression is pivotal for advancing metabolism-centric precision oncology against gastric cancer...

Biosynthetic DNA origami nanostructures: harnessing E. coli-phage systems as nanofactories

DNA origami nanostructures (DONs) serve as versatile nanocarriers with promising application potential, but high production cost and low yield limit their development. The biosynthetic approach based on the Escherichia coli ( E. coli )-phage system offers an effective route for t...

Senescent cancer-associated fibroblasts secrete Tenascin-C to promote tumor progression in high-grade serous ovarian cancer

Cellular senescence is a hallmark of cancer, and senescent cancer-associated fibroblasts (seneCAFs) contribute to tumor progression across multiple malignancies. However, how seneCAFs promote high-grade serous ovarian (HGSOC) remains unclear. We integrated public single-cell RNA...

Dosimetry foil characterisation of a new lithium-target fast neutron source

Accelerator-based lithium-target neutron sources produce fast neutron spectra ideal for nuclear data studies, but simulations of these neutron spectra are not always reliable. Methods for characterising neutron spectra with dosimetry foils have been developed for a new compact fa...

Comprehensive energy efficiency assessment and validation of ship shaft generator and hydrodynamic energy-saving systems under actual operating conditions

Widely used energy efficiency indicators, including the Energy Efficiency Design Index (EEDI), Energy Efficiency Existing Ship Index (EEXI), and Carbon Intensity Indicator (CII), have limitations in assessing the comprehensive energy efficiency of ocean-going ships under actual o...

How teacher support promotes student engagement in AI-supported English learning?: Mediating pathways through personal best goals and academic buoyancy

Artificial intelligence (AI) is changing how university students learn English, but we still know relatively little about how teacher support is associated with student engagement in AI-supported learning. Drawing on Achievement Goal Theory, this study examined whether personal b...

Authentic assessment in an AI-integrated qualitative research methods course

Abstract Authentic assessment has been a recognized aspiration in higher education for nearly four decades, yet its implementation at the undergraduate level has remained constrained by the procedural demands of professional-level work. Generative artificial intelligence reshapes...

Experimental evidence for NOG as a promoter of TGF-β/SMAD signaling in pancreatic cancer cells

Pancreatic adenocarcinoma (PAAD) is a common malignancy characterized by high mortality. TGF-β signaling has been implicated in tumor initiation and development. This study aimed to construct a prognostic model based on TGF-β pathway-related genes for patients with PAAD. PAAD sam...

Bio-inspired flexible pressure sensors: morphology-guided structure–function relationships, reliability, and future perspectives

Bio-inspired flexible pressure sensors have emerged as a major class of soft sensing systems for wearable electronics, electronic skin, human–machine interfaces, and soft robotics because biological structures provide effective design principles for regulating deformation, contac...

MRI findings and pathological features of angiofibroma of soft tissue mimicking soft tissue sarcoma: five case reports and a literature review

Angiofibroma of soft tissue (AFST) is a rare, benign fibroblastic tumor that is difficult to distinguish from malignancies based on radiological and pathological findings. While several reports have described the clinicopathological findings of AFST, there remains little informat...