Research works

Organising cross-border care after arrival: receiving-system challenges in a China–Vietnam border region

Cross-border healthcare is increasingly visible in border regions where patient mobility develops faster than the institutional arrangements needed to support care. Existing research has often examined why patients seek care abroad, while less is known about how receiving health...

Prevalence and prognostic implications of systemic autoinflammatory and autoimmune diseases in myelodysplastic neoplasms: a retrospective Belgian cohort study

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders marked by ineffective hematopoiesis and an increased risk of progression to acute myeloid leukemia (AML). Growing evidence highlights the role of inflammation in MDS pathogenesis, and systemic autoinflammatory and...

Exploring vertical genomic heterogeneity and chemotherapy response using targeted genomic sequencing in muscle-invasive bladder cancer

We performed a targeted genomic sequence of muscle-invasive bladder cancer (MIBC) tissues to investigate vertical intratumoral heterogeneity, invasion processes, and potential biomarkers of platinum-based neoadjuvant chemotherapy (NAC) efficacy in MIBC. Mutations in key genes tho...

Patient-level topology-aware graph transformer for breast histopathology classification

Progress in computational pathology is limited not only by model architecture, but also by evaluation design. In breast histopathology benchmarks such as BreaKHis, multiple correlated image tiles often originate from the same patient; consequently, image-wise splits can inflate p...

Pangenome analyses reveal divergence and extensive introgression in two global corn pests

Introgression between closely related species can profoundly influence evolutionary trajectories, yet how genomic divergence interacts with introgression, especially in invasive hybridization, remains insufficiently understood. Structural variants (SVs), particularly chromosomal...

The complete reproductive cycle of the mudskipper Periophthalmus novemradiatus with reference to previously documented cycle stages of other species within the genus

This study provides the first comprehensive analysis of the entire reproductive cycle of the mudskipper Periophthalmus novemradiatus , monitoring 15 complete and three incomplete cycles filmed continuously day and night over 18 months under simulated tidal conditions. Combining b...

Lithium-ion battery SOH estimation based on degradation physics constraints and cross-attention Transformer-GRU

Accurate estimation of lithium-ion battery state of health (SOH) is essential for battery management systems in safety warning, lifetime management, and energy scheduling. To address the difficulty of simultaneously capturing global feature coupling and local degradation memory w...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...

Sibling group sex composition and gender-typical educational choices

Educational choices are heavily stratified by gender. In this study we examine whether an important structural factor in the family of origin, sex composition of the sibling group, affects the emergence of the gender-typed preferences that may drive these choices. Using Swedish p...

Predictors of Postsurgical Outcomes in Trigger Finger Release: A Retrospective Analysis

Purpose This study aimed to examine factors associated with recurrent trigger finger and postoperative infection after trigger finger release (TFR) surgery. Methods A retrospective analysis was conducted to examine the variables that impact 4 postsurgical outcomes: postoperative...

Structured Documentary Access and Cross-Session Reconstruction Fidelity in Large Language Models: A Controlled Replication Across Three Agents and Three Domains

Large language models operating without persistent memory must reconstruct project context from whatever is available at query time. We report a controlled comparison of reconstruction fidelity under three conditions: no documentary access (SIN), access to the identical corpus wi...

Does resident–tourist value co-creation matter in promoting tourists’ environmentally responsible behaviour? The chain mediation role of perceived value and destination identification

Since tourists' environmentally responsible behaviour (ERB) has a profound impact on the overall sustainable development of a tourism destination, this research aims to examine the underlying mechanism between resident–tourist value co-creation (RVC) and ERB of tourists based on...

Cancer nanovaccine plus doxorubicin and immune checkpoint blockade overcomes chemoresistance and delays postsurgical recurrence

Chemotherapy for solid tumors has serious limitations due to acquired chemoresistance and frequent postsurgical recurrence. In this study, we developed a chemo-immunotherapy regimen combining a chemotherapeutic agent, a dendritic cell (DC)-activating cancer nanovaccine, and immun...

Comparative assessment of occlusal and proximal caries detection using an intraoral scanner and panoramic radiography

Recently, fluorescence-based caries detection has been integrated into intraoral scanners as a radiation-free adjunctive tool for caries assessment. However, evidence regarding the agreement of these systems with conventional diagnostic methods remains limited. Therefore, the aim...

Experiences of Diagnostic Radiographers Imaging People from Prison in Acute Hospitals in the UK: Phase One Findings from the EXPOSE Study

Introduction People in prison experience significant health disparities and rely on acute hospitals for secondary care, including diagnostic imaging. Despite this, little is known about how diagnostic radiographers experience imaging people from prison in acute hospital settings....

Visual elements in food packaging and consumer choice: a moderated mediation analysis of consumer satisfaction in the tea market

This study examines how consumer satisfaction moderates the relationship between visual packaging elements and purchase intention in low-involvement products. Whilst packaging design’s influence on purchase decisions is well-documented, understanding of boundary conditions remain...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production

Helper plasmids that depend on native adenovirus gene expression have long been the standard for transient adeno-associated virus (AAV) production. Here, we demonstrate that engineering the required helper gene expression can greatly increase AAV production relative to the use of...

Identification and validation of CCL28 and CCL5 as chemokine biomarkers and pro-inflammatory mediators in acute pancreatitis: an integrated bioinformatics and experimental study

Acute pancreatitis (AP) is a common inflammatory disease of the exocrine pancreas. Its course ranges from a mild, self-limited illness to severe disease with organ failure. Current clinical tools do not reliably identify patients at risk of progression early in the disease course...

Global cloud phase monitoring from FY-3G multi-angle polarimetric observations using the new MAPLE-CP framework with independent multi-site lidar validation

Global cloud-top phase monitoring is constrained by an observing gap: passive imagers provide broad coverage but limited vertical phase information, whereas active sensors provide stronger physical constraints only along narrow tracks. Here we develop MAPLE-CP, a Multi-Angle Pola...