Research works

Spironolactone versus Bicalutamide for Female Pattern Hair Loss: A 24-Month Unicenter Retrospective Comparative Study of Effectiveness and Safety

INTRODUCTION: Female pattern hair loss (FPHL) is a chronic, progressive condition that affects quality of life. Off-label systemic antiandrogens are increasingly used, but comparative data remain limited. METHODS: To compare the effectiveness, safety, and healthcare resource util...

Integrating multivariate and machine learning approaches to decipher drought tolerance in okra (Abelmoschus esculentus L.)

Drought stress severely limits crop establishment and productivity, driving early-stage screening approaches to identify resilient genotypes under changing climatic conditions. This study evaluated drought tolerance in 15 okra ( Abelmoschus esculentus L.) genotypes at the seedlin...

More high-risk patients but stable levels of healthcare-associated infections and antibiotic use: findings from national point prevalence survey conducted in 2017 and 2022 in the Paris region hospitals

Monitoring healthcare-associated infections (HAI) and antibiotic use (ABU) in hospitalized patients is essential to control infections and reduce the inappropriate use of antibiotics. This study aimed to describe trends in the prevalence of HAI and ABU between 2017 and 2022 withi...

Effects of dosage, inorganic salts and polymers on the high-temperature rheological characteristics of bentonite, attapulgite and sepiolite suspensions

Understanding the high-temperature rheological behavior of mud-forming clays is critical for designing drilling fluids suitable for deep wells. The rheological properties of bentonite (BET), sepiolite (SEP), and attapulgite (ATP) are systematically investigated from 40 to 220 °C...

Evolution of water pattern in Chagan Lake Basin from 2017 to 2025 using PlanetScope images and a newly developed MS-FCN8s algorithm

As a typical lake group in Northeast China, the Chagan Lake Basin's water dynamics are crucial for regional water security and ecological protection. High-resolution images have limited spectral information, water indices perform poorly in complex backgrounds, and deep learning m...

Discrete vs. continuous: how weight unit framing mitigates consumers’ short-weight concerns and boosts online fruit purchase intention

Consumers commonly encounter short-weight issues when purchasing fruit online. This study compares the effect of two weight unit framing approaches(discrete versus continuous) on alleviating consumers’ concerns about short-weight in online fruit shopping. We also reveal the under...

A combined workflow using geology, petrophysics, and geomechanics to locate productive zones and ideal fracture networks

A complete reservoir evaluation requires studying both petrophysical and mechanical rock properties. Accordingly, Well logs are widely used in the oil industry to determine key parameters and locate high-production zones. This study presents an integrated workflow using Formation...

Epidemiology and prevalence patterns of head lice infestation in Isfahan Province, central Iran based on a surveillance study (2017–2024)

This study aimed to describe the demographic, temporal, spatial, and treatment-related epidemiology of head lice ( Pediculosis capitis ) infestation in Isfahan Province, central Iran, using population-based surveillance data. A retrospective population-based analysis was conducte...

Volcanic earthquake swarms at Izu-Oshima in 2023

Earthquake swarms are known to reflect underground fluid movement and stress changes. However, their occurrence patterns and the mechanisms underlying hypocenter migration remain poorly understood. In this study, we focused on two earthquake swarms that occurred at Izu-Oshima in...

Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review

Total neoadjuvant therapy (TNT) has emerged as a key treatment paradigm for locally advanced rectal cancer, reducing distant metastasis rates and facilitating organ preservation in selected patients. However, treatment response remains heterogeneous, highlighting the need for bio...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

Protocol to generate human T cell progenitors that repopulate the thymus

Human pluripotent stem cells (hPSCs) provide a powerful platform for generating T cell progenitors and investigating hematopoietic stem cell (HSC)-independent T cell development. Here, we present a protocol for the directed differentiation of hPSCs to generate early progenitors o...

Green synthesis, characterization, and antimicrobial evaluation of jackfruit seed starch-capped copper oxide nanoparticles in cold creams

Copper oxide nanoparticles (CuO NPs) were synthesized via a green approach by reacting copper sulfate with jackfruit seed starch in its native, annealed, and pregelatinized forms, and were characterized by UV–visible spectrophotometry, Fourier-transform infrared (FTIR) spectrosco...

Fusion at scale: Critical enablers in global energy transitions

Fusion is a promising sustainable energy source that can potentially contribute to achieving the most ambitious climate goals with firm carbon-free baseload electricity. Due to recent advancements, fusion is transitioning from a purely research stage to a pre-commercialisation ph...

MicroRNA-205-5p: a candidate biomarker and mechanistic mediator in polycystic ovary syndrome

The objective of this study was to investigate the impact of microRNA-205-5p (miR-205-5p) on clinical outcomes in patients with polycystic ovary syndrome (PCOS). Eighty PCOS patients and sixty-five healthy individuals were enrolled in this retrospective study. Serum levels of miR...

Latent profiles and predictors of fear of childbirth in late pregnancy: a parity-specific analysis

Fear of childbirth (FoC) is a common psychological concern among women in late pregnancy. Variation in reported prevalence and associated factors across studies reflects methodological heterogeneity and highlights the need for person-centred approaches to identify clinically mean...

RPPH1 drives ovarian cancer cells proliferation via CDK9-c-Myc axis

Dysregulation of the proto-oncogene c-Myc is a critical driver of ovarian cancer progression, yet the mechanisms governing its expression remain incompletely characterized. A systematic bioinformatic analysis was used to screen long non-coding RNA involved in the regulation of c-...

The impact of different learning modalities on dental students: a comparison of video, visual-text, and text-based instruction

Effective teaching methods are essential for improving dental students’ understanding of periodontal surgical procedures. Coronally advanced flap (CAF) surgery requires comprehensive knowledge of anatomical structures, surgical instruments, procedural steps, and possible complica...

Giant Well-Differentiated Liposarcoma of the Spermatic Cord Associated With Inguinal Hernia: Clinical Insights From a Case Report

Patient: Male

Anthropometric PHV-prediction models versus skeletal age in elite Chinese U12–U13 male soccer players: a cross-sectional study

Assessing biological maturity in youth soccer helps reduce maturity-related selection bias. Anthropometric peak height velocity (PHV) prediction models provide non-invasive, repeatable tools for maturity monitoring, but their performance relative to skeletal-age (SA) indicators r...