Research works

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...

Repositioning of cis-flupentixol for the suppression of ovarian cancer cell migration and invasion through ERK5 inhibition

Ovarian cancer (OC) remains the most lethal gynecological malignancy, largely because of its late-stage diagnosis and limited effective screening modalities. Despite therapeutic advances, high relapse rates and therapeutic resistance—particularly in metastatic disease—underscore...

Diagnostic accuracy of cone beam computed tomography in the detection of furcation perforations: an in vitro comparison with periapical radiography and micro-computed tomography

The furcation area is an anatomically complex region where the roots of multirooted teeth diverge. Visualizing pathologies and iatrogenic errors in this region is particularly challenging with conventional radiographic techniques due to factors such as superposition, root morphol...

Genotype-dependent miR-499/SOX5 axis regulation and its association with chronic low back pain risk and severity

The pathogenesis of chronic low back pain (CLBP) is complex and intricately linked to genetic predisposition. This study aimed to investigate the association between the microRNA-499 (miR-499) rs3746444 genetic polymorphism and CLBP, as well as to elucidate the underlying molecul...

A Scalable Cloud-Native Lakehouse Architecture for Epidemiological Forecasting and Constrained Resource Allocation

Disease surveillance systems in resource-constrained public health settings face two distinct challenges: detecting outbreak anomalies in real time, and translating those detections into operationally defensible resource-allocation decisions. Existing approaches typically address...

Decoding non-faradaic signal transduction in organic electrochemical transistor based biosensors

Organic electrochemical transistors (OECTs) combine amplification and transduction, making them attractive for biochemical sensing. Yet, the fundamental mechanisms by which OECTs convert biochemical binding events into electrical signals remain poorly understood, limiting their o...

Navigating intraoperative hypotension: rethinking traditional management for improved patient outcomes

Intraoperative hemodynamic instability and hypotension commonly occur in anesthetized patients and are associated with postoperative morbidity and mortality. A growing body of evidence establishes a strong correlation between intraoperative hypotension (IOH) and adverse events su...

Foreign body–associated maxillary sinus aspergillosis caused by Endomethasone extrusion: diagnostic challenges, biological mechanisms, and surgical management

Extrusion of endodontic sealers into the maxillary sinus is an uncommon but clinically significant complication, particularly when biologically active zinc oxide–eugenol–based materials are involved. Their persistence within the sinus may impair mucociliary clearance and sustain...

Benchmarking one-class and binary classifiers for weld defect detection using acoustic emission signals

The aim of this study is to apply diagnostic techniques to welds based on machine learning methods. This approach works exclusively with signal data, making it nondestructive and enabling easier and faster implementation. It detects anomalies immediately after the welding procedu...

A numerical study of non-Newtonian blood-based hybrid nanofluid flow over a stretching cylinder with Cattaneo–Christov heat flux and homogeneous heterogeneous reactions

Non-Newtonian hybrid nanofluids have attracted considerable attention in biomedical and industrial thermal systems because of their superior heat transfer performance and complex transport characteristics. In particular, blood-based hybrid nanofluids containing copper (Cu) and al...

QL-2026-01 Coverage of evidence, Google Flood Hub: pre-registered protocol v1.9

Pre-registered protocol for an independent evaluation asking how many people live in reach of a river forecast whose accuracy has never been published. The study reanalyses the developer's own released per-gauge metrics, weighted by the population exposed behind each forecast poi...

“We could do more”: exploring violance prevention measures in German outpatient primary care — a qualitative study

Healthcare workers in general practice are exposed to verbal and physical violence from patients and accompanying persons. While research has predominantly focused on hospital settings, evidence on violence prevention in primary care remains limited. General practice staff often...

Cost-effectiveness of a single dose of the adjuvanted respiratory syncytial virus preFusion protein 3 vaccine over 5 years and its potential public health impact among older adults in Italy

BACKGROUND: Respiratory syncytial virus-associated acute respiratory illness (RSV-ARI) is an underrecognized cause of illness in older adults aged ≥ 75 years (OAs) and individuals at increased risk (AIR), contributing to a substantial disease burden. AS01E-adjuvanted RSV PreFusio...

Conservation of Long G4-rich (LG4) genomic enhancer regulations

Long G4-rich regions (LG4s) are defined as DNA sequences containing a high density of guanine triplets capable of forming non-B DNA structures called G-quadruplexes (G4s). These regions frequently overlap with enhancers, which are regulatory DNA elements that modulate gene expres...

Mind the gap: The role of workers’ automation perceptions for the automation training gap

Technological advancements in automation are transforming job tasks and skill demands, raising concerns about the adaptability of the workforce. While reskilling and upskilling are widely recommended for workers in high-risk occupations, empirical research consistently finds an “...

Multi-source energy management in electric vehicles: Performance analysis using metaheuristic optimization strategies

Hybrid energy storage systems (HESS) are considered as the optimal energy source for electric vehicles (EVs). Indeed, optimizing energy management efficiency and enhancing system lifespan are vital to improving the sustainability and reliability of EVs. However, the high charging...

CRISPR screens reveal MCT1-driven metabolic escape from SMAD3 inhibition as a therapeutic vulnerability

Resistance to therapy remains a critical challenge in cancer. This is exemplified by TGF-β pathway inhibitors which, despite broad clinical testing, have failed to deliver survival benefit. More precise SMAD3 targeting has shown preclinical promise, yet resistance mechanisms to S...

Detection of Kankra (Bruguiera gymnorhiza) tree expansion in the northern Sundarbans

Mangroves are vulnerable to environmental changes, which can shift in the dominant species composition across ecological zones. This research aims to develop an object-based image analysis (OBIA) methodology combining Landsat imagery with very high spatial resolution reference im...

Joint effects and mediating mechanisms of body roundness index and biological aging on the risk of incident cardiovascular disease: a nationally representative prospective cohort study

Body roundness index (BRI) and biological aging are critical drivers of cardiovascular disease (CVD). However, their joint pathogenic effects and underlying mechanisms in the development of CVD remain elusive. This study aims to investigate the independent and joint effects of BR...

Experimental investigation of cross-laminated timber panels subjected to near-field blast loads

Research on the performance of structural timber elements subjected to near-field blast loads is lacking, with no known comprehensive experimental studies available to inform design standards and hazard mitigation strategies. This paper presents the results of an experimental tes...