Research works

Multidimensional LDCT Imaging Endpoints for a Randomized Pilot Phase II Trial of Curcumin and Omega-3 Fatty Acids for Lung Cancer Chemoprevention: Results of a Randomized Pilot Trial

Background: Former and current smokers in lung cancer screening remain at elevated risk for lung cancer despite smoking cessation. We and others have shown that curcumin (CUR) exhibits anti-inflammatory and antiproliferative effects but is limited by poor bioavailability. However...

Health economic evaluation of discrete event simulation model for treating chronic obstructive pulmonary disease based on traditional chinese medicine syndrome differentiation

Abstract Objectives To evaluate, from a Chinese healthcare system perspective, the cost-utility of three treatment strategies (Western medicine, Traditional Chinese Medicine [TCM], and combined therapy) for stable chronic obstructive pulmonary disease (COPD) using a discrete even...

Anti-Disturbance Dynamic Memory Event-Triggered Control for Robotic Manipulator Systems

This study investigates the H∞ anti-disturbance dynamic memory event-triggered (ADDMET) control issue for Robotic Manipulator System (RMS) under multiple disturbances. An affine model is adopted to characterize the RMS, accounting for payload variations and complex operating cond...

Improvement in Surface Quality of Ironing Product Using Differential Lubrication

Ironing is an effective process for precisely finishing a formed product at the final stage of a series of forming processes. Generally, a high-performance lubricant oil with high viscosity is used to prevent galling under severe forming conditions, but high-viscosity oil is diff...

Exploring effect of excitation wavelength on upconversion emission in Nd, Yb, Er and Ho tetra co-doped Y2O3 phosphor and use in optical thermometry

This paper examines the effects of excitation wavelength, power, and temperature on the upconversion (UC) emission of phosphors prepared by doping Y 2 O 3 with combinations of four rare earth ions (Nd 3+ , Yb 3+ , Er 3+ , and Ho 3+ ) synthesised via the combustion route. Structur...

Visualizing diagnosis-associated AMPA receptor-related [11C]K-2 PET SUVR patterns across psychiatric disorders using weakly supervised UMAP

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and play a central role in synaptic function, with accumulating evidence in psychiatric disorders. Using [ 11 C]K-2 PET to assess AMPAR-related signals in vivo, we examined whether regional standardized uptake valu...

Interpreting History: Observations on Methodology in Taylor’s The Social Constitution

Abstract This review essay articulates methodological insights gleaned from Whitney Taylor’s The Social Constitution: Embedding Social Rights Through Legal Mobilization (Cambridge University Press, 2023). Through an analysis of how Taylor used interview and comparative methods, t...

Dynamic response characteristics of an entire long span submerged floating tunnel tube under wave and current loads

This study performs a numerical investigation of the dynamic response characteristics of a three-dimensional, full-scale submerged floating tunnel (SFT) tube using finite element software coupled with hydrodynamic analysis subroutines, under regular-wave and combined wave-current...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

The obsolescence of protected area categories in a polycrisis world

Current global conservation models face significant limitations in addressing the global polycrisis, and the constraints of the International Union for Conservation of Nature protected area (PA) classification system are part of the issue. The principles of the new conservation p...

Salt‐Controlled Multistep Phase Separation in Hydroxypropyl Cellulose Colloids for Sustainable Adhesives

ABSTRACT Phase separation is an evergreen subject that shapes our understanding of how order and functionality emerge from disordered complex soft matter systems. Here, we report on the salt‐regulated transition from isotropic liquid‐liquid phase separation to anisotropic liquid‐...

Learning Domains for Undergraduate Dental Behaviour Support: The BeSiDe Curriculum Learning Outcomes

OBJECTIVES: Dental Behaviour Support (DBS) refers to informal and formal strategies and interventions that support patients' acceptance and experience of oral healthcare. DBS plays a crucial role, particularly for vulnerable groups, yet training across dental curricula remains in...

Vessel fractional flow reserve (vFFR) vs. optical coherence tomography in chronic coronary syndromes (VISION-FFR)

Fractional flow reserve (FFR) is the gold standard for evaluating the functional significance of coronary stenosis. With advances in methods based on computational fluid dynamics and three-dimensional vessel reconstructions, non-invasive assessment using indices such as vessel FF...

Preparation of gold nanoparticles supported on microcrystalline cellulose by solid-mortar grinding and their catalytic activities

A solid-grinding approach for transforming microcrystalline cellulose into less ordered matrices, followed by the deposition of a high density of gold nanoparticles (NPs) without employing environmentally toxic chemicals, solvents, or external reducing agents is reported. The gen...

Ginsenoside Rg1Attenuates Neuroinflammation in Parkinson’sDisease Models via Concomitant Modulation of Canonical and NoncanonicalWnt Pathways in Microglial M1/M2 Polarization

Abstract Microglial-mediated neuroinflammation is a core driver of brain disorders. Thus, modulating microglial activity is a critical therapeutic goal. In this study, we explored how Ginsenoside Rg1 (Rg1) protects against the inflammation seen in Parkinson’s disease (PD). Our ex...

Developing a Multidisciplinary Model for Sexual Violence Response in Nigeria: Integrating Legal, Medical, and Social Perspectives

Sexual violence response in Nigeria remains fragmented despite growing legal recognition of sexual offenses and international advocacy for integrated, survivor-centered approaches. Existing interventions largely operate in institutional silos, limiting continuity of care and surv...

TrivalentAl Insertion into Layered-Oxide-DerivedPerovskite Oxynitrides for Defect-Controlled Dielectric Response

Abstract Al-containing perovskite oxynitrides, SrAl0.2M0.8O2.4N0.6 (M = Nb, Ta), were synthesized by ammonolysis of layered Sr5M4O15 precursors with α-Al2O3. This reaction demonstrates that the cation-insertion chemistry of layered-perovskite-derived oxynitrides can be extended t...

Unconventional BiocatalyticStrategies Orchestratethe Synthesis of the Nucleoside Analog Sinefungin

Abstract Sinefungin is a potent nucleoside antimetabolite of S-adenosylmethionine (SAM). Since its discovery in the 1970s, sinefungin has generated significant scientific interest owing to its role as a bioisostere of SAM and its broad range of biological activities. Despite cons...

The diagnostic and prognostic value of serum FBXO11 expression in neonatal sepsis

This study aimed to investigate the correlation between serum FBXO11 expression and serum PCT and CRP levels as well as its diagnostic and prognostic value in neonatal sepsis (NS). This study included 120 patients with NS aged ≤ 28 days, birth weight > 2500 g, and gestational age...

Preliminary experience of mechanical thrombectomy treatment in pediatric arterial ischemic stroke: a retrospective case series

To evaluate the feasibility and efficacy of mechanical thrombectomy in the treatment of pediatric acute ischemic stroke (AIS). The clinical data, radiographic results and management outcomes of children diagnosed with AIS and treated at our hospital between 2016 and 2021 were ret...