Research works

Unraveling TB Dynamics in Nepal: Navigating Progress, Challenges, and Initiatives

Background: To assess the progress made in TB control, identify persistent challenges hindering effective TB control efforts, and identify the initiatives and recommendations to achieve End TB Strategy. Design/Methods: The study employed a multi-phase approach, combining quantita...

The Effects of Expressive Arts Therapy on Emotion Regulation and Aggression in Violent Offenders: A Randomized Controlled Trial

Violent crime is a widely recognized public health concern. According to emotion regulation theory, aggressive behavior in violent offenders is linked to maladaptive emotion regulation strategies. However, few studies have explored interventions targeting emotional factors to red...

BoDV-1 Infection Is Associated with Altered Prion Protein Glycoform Maturation and Reduced ETS1-MGAT5/GnTV Pathway Activity in Rat C6 Astroglial Cells

Borna disease virus 1 (BoDV-1) is a noncytolytic, neurotrophic virus that causes neurological disorders, where astrocytes contribute to neuropathology. Cellular prion protein (PrPC) is involved in pro-survival signaling and antioxidative defense. Using rat astroglial C6 cells as...

Influence of Composite Mineral Admixtures and Expansive Agent on the Mechanical Properties, Durability and Microstructure of Cementitious Materials

To improve volume stability and durability of cementitious materials, a composite mineral admixture including ground granulated blast furnace slag, fly ash and silica fume was incorporated at a fixed 12% replacement ratio together with varying dosages of an expansive agent (EA)....

Time-resolved imaging of antiferromagnetic skyrmion interactions

Abstract Quantifying particle interactions is central to understanding and controlling collective dynamics in particle-based devices such as those comprising skyrmion ensembles. Here we directly visualize, in real time, the nanosecond current-driven dynamics of an antiferromagnet...

The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial

Background: Prostaglandin E2 (PGE2) suppresses perinatal breathing. Reducing antenatal PGE2 concentrations with paracetamol could stimulate spontaneous breathing in premature infants at birth. We aimed to assess feasibility and potential effects of antenatal paracetamol. Methods:...

Distinct learner profiles of attitudes toward biostatistics in medical education: a latent profile analysis

Biostatistics is essential for interpreting evidence and clinical decision-making, yet medical learners may value it while experiencing anxiety, low enjoyment, and perceived difficulty. Average scores may fail to capture distinct attitude patterns. This study aimed to identify la...

NCOA4-Mediated Ferritinophagy Contributes to Iron Overload-Driven Ferroptosis of Senescent Myoblasts in Mice

Sarcopenia is an age-related pathological syndrome characterized by progressive and generalized loss of skeletal muscle mass and function, with muscle atrophy representing its cardinal pathological hallmark. Ferroptosis, an iron-dependent regulated cell death, has been implicated...

Coppiced sweet chestnut in the construction of imperfect gridshells from asymptotic curves

In recent years, bending-active gridshells with asymptotic geometry have been successfully constructed at the architectural scale. These have typically used materials such as steel and machined timber, with thin rectangular profiles and predictable characteristics. This paper inv...

Trustworthy Gait Analysis for Computer-Aided Diagnosis in Parkinson’s Disease and Knee Osteoarthritis: A Targeted Narrative Review of Algorithms and Clinical Validation

Gait analysis is increasingly used as a dynamic functional biomarker for computer-aided diagnosis (CADx), although strong internal performance alone does not establish clinical utility. This targeted narrative review examines Parkinson’s disease (PD) and knee osteoarthritis (KOA)...

Online Parameter-Reconfigured Model Predictive Control for Integrated Trajectory Tracking of Distributed Four-Wheel Steering Vehicles

To overcome the limitations of conventional model predictive control (MPC) for trajectory tracking of distributed-drive four-wheel-steering (4WS) vehicles, particularly its fixed weighting matrices and prediction and control horizons, this study investigates the integrated trajec...

TRIM28 regulate G2/M transition via histone modification and DNA damage repair during mouse oocyte meiosis

TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. However, transcriptional activity is barely detectable during oocyte meiotic maturation. In this study, we explored the role...

Managing Disease, Daily Life, and Biography

Physical activity is widely recognized for its beneficial effects on people living with epilepsy, including those with severe forms. However, its practice often remains limited due to perceived risks associated with seizures. In the absence of guaranteed adaptation and safety con...

Developing Empathy Quest: A Digital Game Based Learning Tool About Teachers’ Emotional Intelligence

Socio-emotional skills are essential for teachers’ wellbeing, classroom functioning, and promotion of students’ social–emotional development. Digital game-based learning (DGBL) represents a promising approach to promote these competencies through engaging and experiential learnin...

Corpus linguistics in the age of generative AI: practical and theoretical considerations

Abstract Generative AI tools have implications for corpus linguistics from practical and theoretical angles, both of which the current paper addresses. The first part of the paper establishes whether and how generative AI tools – here ChatGPT o3 – can in practice support a corpus...

Perennial Crop Type Discrimination with AVIRIS-NG Hyperspectral Imagery and Machine Learning

Accurate maps of perennial crop types support agricultural monitoring, water-use accounting, and strategic decisions on climate adaptation. Hyperspectral imagery offers the fine spectral detail needed to separate spectrally similar plant species, but its high dimensionality compl...

Simultaneous Bilateral Quadriceps Tendon Rupture After Low-Energy Trauma in a 73-Year-Old Man: A Case Report and Literature Review

Simultaneous bilateral quadriceps tendon rupture is an exceptionally rare injury of the knee extensor mechanism and may present a diagnostic challenge, particularly after low-energy trauma. Prompt recognition is essential to restore knee extension and ambulatory function. We repo...

Integrating Experimental Measurements, WinXCom Calculations and Monte Carlo Simulations to Evaluate the Ionizing Radiation Shielding Performance of UPR/Bi2WO6 Nanocomposites

Lead-free polymer nanocomposites have attracted considerable attention as sustainable alternatives for ionizing radiation shielding. In this study, unsaturated polyester resin (UPR) nanocomposites containing hydrothermally synthesized Bi2WO6 nanoparticles (2.5–10 wt.%) were fabri...

Nanoplastic detection and quantification in high-altitude glacial snow samples from Italy, Switzerland and France

Abstract Plastic pollution is an ever-growing concern around the globe, with current research portraying the presence of contaminants even in previously pristine regions. Especially small particles, micro- and nanoplastics, can be dispersed over long stretches by atmospheric tran...

Energy Evolution and Acoustic Emission Characteristics of Tailings Backfill with Different Fly Ash Content

Abstract In this paper, with the help of acoustic emission (AE) monitoring technology, the mechanical properties of tailings backfill under uniaxial compression with three kinds of fly ash (FA) content, slurry concentration of 70%, and ash-to-sand ratios of <mml:math xmlns:mml="h...