Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
130483 work(s)
- Health & MedicineOpen access
Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...
- Health & MedicineOpen access
Practices of community pharmacists towards COVID-19 treatment in Vietnam: a simulated client study
<title>Abstract</title> Background Recent reports have raised concerns about drug overuse and misuse in self-medication practices for COVID-19 treatment. This study was aimed to assess the availability and appropriateness of medication dispensing provided by community pharmacists...
- AI & ComputingOpen access
Abstract. We introduce a general technique for proving membership of search problems with exact rational solutions in PPAD, one of the most well-known classes containing total search problems with polynomial-time verifiable solutions. In particular, we construct a “pseudogate,” c...
- AI & ComputingOpen access
Unmasking conversational bias in AI multiagent systems
Detecting biases in the outputs produced by generative models is essential to reduce the potential risks associated with their application in critical settings. However, the majority of existing methodologies for identifying biases in generated text consider the models in isolati...
- Society & EconomicsOpen access
“Prison is routine”: Narrating release and reintegration in settler colonial Canada
This article examines how long-term prisoners in Western Canada narrate their anticipated re-entry to a settler-colonial society using a narrative approach to analyze 147 interviews with federally incarcerated people. The great majority of our participants describe experiencing c...
- Climate & EnvironmentOpen access
The effects of CO2-rock interaction on the failure mode of clay-rich sandstone
Understanding how rock formations respond to CO₂ injection is critical for geological carbon storage. This study examines the impact of CO₂-rock interaction on the failure mode of clay-rich Tuscaloosa sandstone. To simulate CO₂-rock interaction in the subsurface, we conducted CO...
- Health & MedicineOpen access
Abstract Background Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemod...
- Health & MedicineOpen access
ABSTRACT Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by ph...
- Climate & EnvironmentOpen access
Urban green spaces (UGS) play an important role in mitigating urban heat island effects. However, the mechanisms underlying their cooling effects are still not fully understood, particularly regarding the role of three-dimensional vegetation structure and nonlinear threshold resp...
- BiologyOpen access
Bidirectional AllostericLigand Regulation in a CentralGlycolytic Enzyme
Abstract Allosteric regulation enables fine-tuned control of enzyme activity in response to cellular signals, yet its molecular basis often remains unclear. Phosphofructokinase-1 (PFK), the highly conserved, rate-limiting glycolytic enzyme, is a paradigm for Monod–Wyman–Changeux...
- Biology
Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease
Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...
- Materials & EnergyOpen access
Saturable absorption in NV-doped diamond studied by femtosecond Z-scan
Nonlinear optical absorption in commercially available diamond crystals containing nitrogen-vacancy (NV) centers is investigated using femtosecond open-aperture Z-scan measurements at a wavelength of 1032 nm. Experiments were performed on a high-purity electronic-grade diamond an...
- AI & ComputingOpen access
Agentic AI: Vision and challenges
Agentic AI systems are increasingly viewed as a viable response to the shortcomings of static, rigid, and human-in-the-loop Artificial Intelligence (AI) systems. This is because autonomous operation enables rapid adaptation to dynamic, complex problems with improved time-critical...
- BiologyOpen access
Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes
Abstract Aims/hypothesis Immunotherapies such as Teplizumab can preserve residual beta cell function in individuals with newly diagnosed type 1 diabetes (T1D), but treatment response is variable. Currently, no biomarker exists to identify individuals most likely to benefit from i...
- Engineering & TechnologyOpen access
vascr: An R-based toolkit for rapid and robust analysis of cellular impedance sensing data
Abstract Purpose Electrical impedance sensing offers a powerful, non-invasive method for real-time monitoring of cellular behaviour, with applications spanning immunology, cancer biology and drug discovery. Adoption of impedance-sensing approaches has been accelerated by the comm...
- Society & EconomicsOpen access
Purpose: The relationship between the set for variability (SfV) task and various isolated word reading measures in developing readers is high (ranging from .60 to .80 across studies). Elbro et al. (2012) offered that SfV skill serves as a second step in the decoding process allow...
- Health & MedicineOpen access
Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...
- Society & EconomicsOpen access
The founding question of the PDL programme — what distinguishes something that exists from something that does not — is answered in axiom C1 by the postulate of a repeatable, non-trivial binary alternation. The corpus has never argued for C1; it has only assumed it. This document...
- Health & MedicineOpen access
A GCPA-SIDCER position paper in the Science, Policy, and Ethics in Conversation (SPEC) series. Drawing on the FSCI 2026 course 'Who's afraid of knowing?', which the author chaired, and on the reform of research assessment, the paper argues that artificial intelligence has become...
- Climate & EnvironmentOpen access
Potential glacier contributions to the 2024 La Bérarde flood
Abstract. On 20–21 June 2024, an unprecedented flood of the Etançons river caused important damage to the village of La Bérarde (Écrins, France). An analysis of the event showed that the flood was caused by the combination of an intense rain-on-snow event at high altitude and the...