Research works

IMPLEMENTATION EFFECTIVENESS OF THE INNOVATION PROJECT PORTFOLIO MANAGEMENT MECHANISM AND ITS PROSPECTIVE STRATEGIC FORECAST

This paper examines the mechanism of innovation project portfolio management as an alternative to evaluating individual innovation projects in isolation, and assesses the conditions under which its implementation proves effective in practice. Drawing on portfolio theory, stage-ga...

Fecal filtrate transplantation as salvage therapy for fulminant Clostridioides difficile infection in adult hematological patients during chemotherapy-induced aplasia: a pilot experience

Background Fulminant Clostridioides difficile infection (CDI) in patients with hematologic malignancies during chemotherapy-induced aplasia carries high mortality and limited treatment options. Our objective was to evaluate fecal filtrate transplantation (FFT) as a salvage therap...

Integrating Traditional Knowledge Systems into Geriatric Care: The Behavioral Philosophy of Yagya

Modern healthcare often addresses aging and lifestyle disorders through purely external interventions, frequently overlooking the inner dimensions of human behavior and consciousness. This article explores the ancient Indian philosophical concept of Yagya as a multidimensional fr...

Tetrix: A novel Tetris-based paradigm for neuroimaging research and clinical applications

Abstract Tetris is a widely used computer game, not only for entertainment purposes but increasingly in cognitive and clinical neuroscience research. Despite its frequent application in experiments, the neural mechanisms underlying gameplay remain insufficiently understood. Prior...

Reliability of the Biomechanical Assessment of the Sagittal Thoracic Spine on Radiographs Used in Clinical Practice: A Systematic Literature Review

Background: Measurement reliability of the sagittal thoracic spine, e.g., thoracic kyphosis and balance, on radiographs has an unknown evidence base. This literature review aims to systematically identify and evaluate the reliability of biomechanical assessments of the sagittal t...

Optimising glycaemic control in cardiac surgery: narrative review and author recommendations

Abstract Objectives Diabetes and peri-operative hyperglycaemia are associated with increased morbidity and mortality following cardiac surgery. Despite this, specific guidance on peri-operative glycaemic management during cardiac surgery is lacking in United Kingdom (UK) and Euro...

Leadership under value pluralism: managing sustainability trade-offs

Purpose This paper reconceptualizes sustainability leadership as a process of decision-making under value pluralism, where leaders must navigate persistent trade-offs among legitimate but incommensurable economic, social and environmental values. It aims to advance sustainability...

Evaluating Spatial Distribution of Cultural Ecosystem Services (CESs) Based on Rural Landscape Characteristics

Cultural ecosystem service (CES) assessment is essential for comprehensively understanding and evaluating ecosystem services. Optimizing the spatial zoning of CESs can provide more targeted information for ecosystem management. By identifying the typical landscape characteristics...

AI-Enabled Organizational Dependency: Assurance, Capability, and the Case for Accepted Frameworks

Abstract Organizations are rapidly adopting artificial intelligence because they expect it to create value. As reliance grows, they redesign work, reallocate resources, and change organizational capabilities. Some of those capabilities may later be needed to recognize problems, e...

EuroMillions Breakthrough Mining — 2772 Sources, 23336 Leads Extracted — E8 Intelligence Research

Mined 2772 lottery+quantum breakthroughs. Extracted 23336 leads across 13 categories. 21112 high-value leads found. Categories: {"CORRIDOR": 1976, "FORMULA": 1812, "GEOMETRIC": 854, "FORWARD_ATTEMPT": 2096, "QUANTUM": 2306, "TIMING": 256, "CELESTIAL": 1903, "GEMATRIA": 1998, "CON...

From accelerated development to constrained lifecycle: enabling sustainable vaccine supply through platform knowledge and regulatory reliance

Vaccination remains one of the most effective public health interventions. The COVID-19 pandemic raised expectations for how rapidly vaccines can be developed, assessed, and supplied, while also highlighting where quality and regulatory frameworks continue to limit efficiency aft...

Ancient Babylonian Tablet Reveals World's Oldest Trigonometric Table — E8 Intelligence Research

FINDING: Babylonian Plimpton 322 is a sexagesimal trigonometric table based on exact Pythagorean triples, not a simple accounting record. | MATH: Base-60 (sexagesimal) system; Pythagorean triples generated via reciprocal pairs (p, q) yielding (p²−q², 2pq, p²+q²); tablet lists 15...

Espalier: the dependency map method, with companion specifications Capability Hosts under Espalier and Agent Debugging under Derivation

Espalier is a structure-first engineering standard for codebases co-developed by humans and AI agents. Design documents customarily stop one level above the component; every relationship they leave unstated is improvised at implementation time, and improvised relationships are wh...

m6A epitranscriptomic regulation in asthma: mechanisms and therapeutic prospects

Asthma is a heterogeneous airway disease in which chronic inflammation, epithelial barrier injury, immune-cell imbalance and airway remodeling interact to shape variable clinical phenotypes. N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, has...

Predictive Value of Impacted Maxillary Canine Using Panoramic Radiography and Cone Beam Computed Tomography - A Retrospective Study

Abstract Introduction: Impacted maxillary canines (IMCs) are common eruption disturbances associated with incisor root resorption. Panoramic radiography (PR) is routinely used for initial assessment, but its reliability in localising IMCs is limited. Cone beam computed tomography...

Tinea capitis among children under eighteen years of age in Sub Saharan Africa a systematic review and meta analysis

Tinea capitis is a prevalent superficial fungal infection of the scalp and hair that causes significant morbidity and social stigma among children. Sub-Saharan Africa (SSA) bears a high burden due to climatic and socioeconomic factors. This review aimed to estimate the pooled pre...

A Dual Magnetic‐Centrifugal Field Strategy for Orienting Thermal Fillers in High Thermal Conductivity Composites

ABSTRACT The exceptional thermal conductivity of 2D nanomaterials is often compromised by their random orientation in composites, which greatly limits the application of such fillers in thermal interface materials field, and this random orientation is determined by extra degrees...

The traumatic grief inventory self report: validation in the balinese population

Background The Traumatic Grief Inventory Self-Report version (TGI-SR) is a well-known and validated 18-item self-report measure to assess symptoms of Prolonged Grief Disorder (PGD; ICD-11 and DSM-5TR). No validation study has yet been performed in the Balinese population.Methods...

CLINICAL AND PROGNOSTIC FACTORS OF FUNCTIONAL RECOVERY IN PATIENTS WITH HEMORRHAGIC STROKE

Spontaneous intracerebral hemorrhage (ICH) remains a leading cause of mortality and long-term disability worldwide. Accurate prediction of functional recovery is essential for optimizing treatment and rehabilitation strategies. The objective of this study was to evaluate clinical...

A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging

ABSTRACT Genomic instability is a key driver of ovarian aging, impairing granulosa cell (GC) function and diminishing ovarian reserve. However, the regulatory mechanisms underlying GC genomic homeostasis remain poorly defined. This study investigates the novel role of DELTEX2 (DT...