Research works

Mechanistic insights into ultraviolet-crosslinked sulfonated hyaluronic acid microspheres for stable biointerfaces on biodegradable cerebrovascular magnesium implants

Ischemic stroke remains a leading cause of death and disability worldwide, highlighting the urgent need to develop safer and more effective cerebrovascular implants. Biodegradable magnesium (Mg) alloys offer advantages such as high mechanical strength and the presence of neuropro...

PCHP‑1 A from Polygonatum cyrtonema Hua alleviates APAP‑induced acute liver injury via Nrf2/Keap1 and NF‑κB pathways

Acetaminophen (APAP), a common antipyretic and painkiller, can cause hepatotoxicity and severe liver injury when used in excess, and therapeutic options are quite limited. Polygonatum cyrtonema Hua polysaccharide (PCHP) exhibits good anti-inflammatory and antioxidant properties....

Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study

Pro-Xylane is a potent anti-aging ingredient; however, there is limited knowledge regarding whether a comprehensive post-procedure regimen incorporating a combination of Pro-Xylane, niacinamide, and panthenol alongside other active agents can deliver synergistic benefits for both...

An improvement of the Krasikov–Lagarias lower bound for the 3x+1 problem: π_a(x) ≥ Δ·x^0.8892

Let π_a(x) be the number of integers n ≤ x whose 3x+1 trajectory reaches a. Krasikov and Lagarias (Acta Arith. 109, 2003) proved π_a(x) ≥ Δ·x^0.84 for a ≢ 0 (mod 3) via a feasible solution of their nonlinear program L_11^NT(λ); that exponent has remained the published record (cit...

Effect of integrated die-casting on microstructure and mechanical properties of large-scale complex thin-walled RE-Mg alloy components for new energy vehicles

In this work, vacuum-assisted high-pressure die casting (HPDC) was employed to fabricate an integrated RE-Mg alloy rear floor for new energy vehicles (NEVs). The correlations among microstructure evolution, mechanical properties, melt flow, and filling behavior of the integrated...

Family functioning and academic procrastination in primary school students: the longitudinal mediating role of personal growth initiative

Academic procrastination is associated with students'' academic adjustment, yet longitudinal evidence from primary school populations remains limited. This study examined reciprocal longitudinal associations among family functioning, personal growth initiative (PGI), and academic...

Site-specific programming characterizes dynamic post-translational acetylation of histone H2B lysine 108 in mouse embryonic stem cells

Dynamic histone modifications are critical for regulating stem cell fate. However, generalized strategies for site-specific programming of histone modifications profiling on unperturbed chromatin in embryonic stem cells (ESCs) remain challenging. In this study, we established a g...

A Biomechanical Analysis of Intramedullary Threaded Nail Fixation and Dorsal Plate and Screw Fixation for Metacarpal Base Fractures

Purpose The biomechanics of surgically treated metacarpal base fractures are poorly described. We hypothesized that intramedullary threaded nail (IMTN) fixation and dorsal plate and screw (DPS) fixation would perform similarly in multiple fracture locations approaching the metaca...

Tools for measuring quality of care in breast surgery

Breast cancer is the most common malignancy in women, and surgery remains a cornerstone of treatment. Traditional quality indicators, such as complication or margin status, often fail to capture the overall quality of surgical care. In recent years, indicators such as Textbook Ou...

Crystalline topographical construction: endogenous grooves as physical cues for stem cell regulation in bone regeneration

Micro/nano-topographical cues are potent regulators of cellular behavior and function. However, conventional fabrication techniques (e.g., photolithography, nanoimprinting) rely on complex exogenous processing that often induces surface energy loss and impairs biological signal t...

End-Stage Renal Disease as a Predictor of Ray Amputation and Other Postoperative Sequelae in Finger Amputation

Purpose Patients with end-stage renal disease (ESRD) have high rates of pathologies, which may necessitate finger amputation, such as infection or vascular insufficiency. Still, little work has examined its significance in upper-extremity amputation. This study aimed to explore E...

Application of CNV-seq combined with chromosome karyotyping in prenatal diagnosis of pregnant women with high-risk NIPT results

Non-invasive prenatal testing (NIPT), which utilizes fetal cell-free DNA (cffDNA) in maternal peripheral blood to assess the risk of fetal chromosomal abnormalities, has been widely used for prenatal screening. Chromosome karyotyping and low-depth whole-genome copy number variati...

Local economy impacts of a planned ultra-deep-water quay development in the Scottish Shetland Islands

Creating new port infrastructure is essential in unlocking energy and net-zero transition pathways globally. In addition to standard business planning, it is increasingly important to build an understanding of how investment that extends port infrastructure to increase operating...

The role of a major sport event for shaping gender-specific attitudes towards democracy

This study examines the role of the UEFA EURO 2024 in shaping women and men residents’ attitudes towards democracy. The German government adds a new perspective to the national soft power literature by considering a major sport event a tool for promoting democracy. Social role th...

Sedentary behaviour change: barriers and strategies reported by individuals with type 2 diabetes during a multi-component intervention

Abstract Introduction Engaging in high volumes of sedentary behaviour increases the risk of adverse health outcomes, especially for individuals with Type 2 diabetes mellitus (T2DM). Understanding likely influences on behaviour and effective strategies for reducing sedentary time,...

Extrema of a(n)/n^(log_phi 2) for the Fibbinary Numbers on Intervals Between Consecutive Fibonacci Numbers

This note studies the Fibbinary numbers, OEIS A003714, through the map that transfers the digits of the Zeckendorf representation of an integer to the corresponding binary place values. Writing κ=log⁡φ2\kappa=\log_\varphi 2, it determines the exact maximum and minimum of a(n)/nκa...

Full Reusable Synthetic Observational Data Generation for Cosmological Special and General Relativity vs Lamda CDM:Python Code, Complete Data tables, and Deep Numerical Comparison-Which Predicts Better?

We present full reusable synthetic observational data generation for Cosmological Special Relativity(CSTR) and Cosmological General Relativity(CGR), versus Lamda CDM, with complete Python code and full data tables for reuse.

Study on Coupling‑Evolution Mechanism of Matter‑Antimatter and Generation Law of Particle Steady‑State

To reveal the underlying mechanisms of fundamental physical phenomena including micro‑particle evolution, matter‑antimatter asymmetry and fixed particle chirality, this paper constructs a novel fractional‑charge three‑body coupling‑evolution model based on the original time‑super...

Luminescence dating of offshore tsunami deposits from the Shetland Islands, United Kingdom

Abstract. With onshore geological evidence of three tsunami events, the Shetland Islands (UK) yield the most-detailed Holocene tsunami record in the North Sea region. Lately, tsunami deposits were also identified in shallow waters offshore the Shetland Islands. These offshore tsu...

The lifetime of the coherent response: sealed laws of its rise, its peak, and its fall

When a recurrent network is perturbed, how long does its stimulus-locked response live? We define T_c as the post-stimulus time by which the coherent (cross-trial-reproducible) response accumulates 80% of its energy, and report its life-cycle as sealed results (public preregistra...