Research works

Maternal house dust–related cleaning behaviors during pregnancy and neurodevelopment from 18 months to 3 years of age in the Japan Environment and Children’s Study

To examine the association between maternal house dust–related cleaning behaviors during pregnancy and neurodevelopmental outcomes from 18 months to 3 years of age. Data from 81,125 mother–child pairs who participated in the Japan Environment and Children’s Study (JECS) were anal...

Where planetary solids survive sublimation around young and hot white dwarfs

Abstract All observed planetary systems orbiting single white dwarfs have lived through the hot stellar transition from an asymptotic giant branch star. In this post-nebular transition period, the initial conditions for planetary system evolution throughout white dwarf cooling ar...

Local Glucocorticoid Metabolism in Post-traumatic Stress Disorder: The Emerging Role of 11-hydroxysteroid Dehydrogenases

Post-traumatic stress disorder (PTSD) is a complex psychiatric condition arising from exposure to severe trauma, characterized by intrusive memories, avoidance, negative alterations in cognition and mood, and hyperarousal.Despite advances in understanding its neurobiology, effect...

Association of PR Interval with Illness Duration and Lymphocyte Count in Asian Adults with Bipolar Disorder

Objective: Individuals with serious mental illness are predisposed to a heightened risk of cardiac arrhythmias, with specific subtypes demonstrating a disproportionately high prevalence in Asian populations.An overlapping pathophysiology is hypothesized to underpin this clinical...

A fitness advantage from the pLVPK plasmid fuels the global spread of a carbapenem-resistant hypervirulent Klebsiella pneumoniae high-risk clone: ST11-KL64

BACKGROUND: The global emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), particularly the ST11-KL64 subclone acquiring pLVPK-like virulence plasmids, represents a critical public health threat. This study investigates the epidemiological dominance a...

The association of involvement in clinical activities and job satisfaction among hospital and community pharmacists: an application of Herzberg’s two factor theory

The role of pharmacists in providing clinical activities has been expanded in several countries to address the increasing demand for healthcare services. This paper aims to (1) quantitatively investigate the relationship between job satisfaction and involvement in clinical activi...

Gender differences in STEM careers: autonomy-supportive climate, metacognitive strategies, self-efficacy, and their association with academic performance and satisfaction

STEM education has always played a central role in scientific and technological advancement; however, recent years have seen heightened attention to the academic challenges faced by students in STEM programs. An important one is that in a predominantly male environment like that...

Associations of cognitive beliefs and metacognitive processes with eating behavior in adults with obesity and healthy-weight controls: a cross-sectional study

Emotional and uncontrolled eating are common in obesity and may persist despite pharmacological or surgical treatment. Automatic thoughts and metacognitive beliefs may contribute to maladaptive eating, but have rarely been examined together while accounting for depression, anxiet...

Magnesium-containing hierarchical porous scaffold incorporating alpha-lipoic acid ethosomes for neurovascularized bone regeneration under diabetic conditions

Diabetes mellitus severely impairs bone regeneration due to a compromised neurovascular microenvironment. Current therapeutic approaches frequently overlook the need to support neurovascular repair under hyperglycemic conditions, leading to suboptimal bone defect healing. To addr...

Probiotics for the prevention and treatment of oral candidiasis: a systematic review and meta-analysis

Oral candidiasis is a common opportunistic fungal infection, and increasing antifungal resistance has encouraged the investigation of alternative therapeutic approaches, including probiotics. This systematic review and meta-analysis evaluated the effects of probiotics on microbio...

Indoxyl sulfate–associated vascular calcification is linked to mTORC1 and ER stress–integrated stress response signaling

Medial vascular calcification is a major cardiovascular complication of chronic kidney disease (CKD), with the uremic toxin indoxyl sulfate (IS) implicated in its pathogenesis. However, the molecular mechanisms by which IS promotes vascular calcification remain incompletely under...

Early Radiographic Changes Predict Radiographic Stability in Distal Radius Fractures: Development and Validation of an Explainable Predictive Model

Purpose To determine whether early radiographic trajectory data can predict the timing of stability in conservatively managed distal radius fractures (DRFs) and to identify which clinical and radiographic features most influence stabilization timing. Methods This retrospective co...

The Chemical Gap Layer: Locating the Arena of Matter Coupling and Decoupling (EN)

Ontological localization of the arena of chemistry: matter couples and decouples in the gap layer. Four bond types = four forms of gap residence; reactions = gap-residence reconfiguration events; shells = the residence-depth spectrum, ionization energies its depth reading. Four q...

The effect of armed conflict, climatic variations, and food insecurity on internally displaced populations in Somalia

Droughts and conflict-related crises have frequently affected Somali states over the past three decades. Analyzing the drivers of displacement during crisis can provide critical insights for governmental and humanitarian efforts aimed at mitigating these effects. The study aimed...

Cervical facet nerve blockade improves head relocation accuracy for sagittal movements, shoulder joint relocation accuracy for shoulder abduction and standing balance in patients with chronic cervical pain

To investigate whether unilateral cervical facet nerve blockade (FNB) is associated with changes in head repositioning accuracy (HRA), shoulder joint relocation accuracy (JRA), and standing balance in patients with chronic neck pain. This retrospective single-center interventiona...

Common lumbar spine MRI findings in adults with low back pain at Port Moresby General Hospital radiology department, Papua New Guinea

Introduction Back pain is a leading cause of disability worldwide. The presentation, detection, and characterization of lesions in back pain are sometimes clinically indistinguishable, necessitating the use of Magnetic Resonance Imaging (MRI). MRI provides useful information that...

Multielement Composition and in Vitro Bioaccessibility in Brazilian Edible Floral Supplement Capsules Containing Dandelion and Hibiscus

Dandelion (Taraxacum officinale) and hibiscus (Hibiscus sabdariffa) are notable unconventional edible flowers (UEFs) that have traditionally been used as food and in herbal preparations. This study examined the in vitro bioaccessibility content of six elements (Cr, Cu, Fe, Mn, Ni...

PrEgabalin for Treatment Resistant generalised Anxiety disorder (PETRA): study protocol for a double-blind randomised controlled trial set in the UK

Generalised anxiety disorder (GAD) is common and increasingly recognised in primary care. Although antidepressants and psychological therapies are first-line treatments, many patients have residual anxiety and limited access to therapy. Evidence for effective next-step pharmacolo...

Advances in layered double hydroxides with corrosion inhibitors for effective corrosion protection of magnesium and aluminum alloys: A review

Owing to their distinctive lamellar structure, compositional tunability, and excellent anion-exchange capability, layered double hydroxides (LDHs) can provide both passive barrier protection and active corrosion inhibition. Consequently, LDHs have emerged as highly versatile and...

An integrated evaluation and uniformity control process for jet grouting column diameter in interlayered soils

Controlling the diameter of jet-grouted columns is difficult because of variable ground conditions and the complex interaction of grouting parameters. As jet grouting is increasingly used in space-constrained and traffic-intensive areas, traditional trial-and-error pilot tests ar...