Research works

Techno–economic optimisation of hydrogen geological storage in UK depleted gas reservoirs

Long-duration energy storage is becoming critical in the UK to manage renewable intermittency, prolonged low-generation periods, and energy curtailment. Depleted natural gas reservoirs offer a promising option for large-scale underground hydrogen storage because of their substant...

Optimizing CRISPR/Cas9 mutagenesis in Drosophila dendritic arborization neurons to avoid cytotoxicity

Abstract Genetic perturbations are one of the great strengths of the model organism Drosophila melanogaster, with approaches such as classical mutagenesis and RNA interference enabling a wealth of biological discoveries. A more recent approach for altering gene expression is CRIS...

Genome assembly and annotation of two clinical Naegleria fowleri isolates from Costa Rica

ABSTRACT Here, we report the genome assembly and annotation of two clinical isolates of Naegleria fowleri from primary amebic meningoencephalitis cases in Costa Rica in 2020 using Illumina sequencing. Each assembly comprised 37 reference-guided scaffolds, with genome sizes of app...

An Edge Computing-Enabled Optimal Control Method for Low-Voltage Distribution Networks

High penetration of distributed photovoltaic (PV) generation in low-voltage distribution networks can cause voltage violations, limited PV accommodation, and uneven loading among neighboring distribution transformers (DTs). To address these issues, an edge computing-enabled optim...

Phi-Coupled E8 Cascades Drive Hyperbolic Topological Quantum Computing — E8 Intelligence Research

Under the 132 Hz driving tone, the 240 E8 root vectors exhibit a phi‑symmetric eigenvalue flow that simultaneously creates two interlocking sets of topological edge modes on the {5,3,4} hyperbolic lattice. These edge modes lock into a hierarchical cascade where each level amplifi...

Cost-effectiveness analysis of Cardioform vs. Amplatzer: concerns regarding methodological transparency and interpretation of clinical results

Volpi et al. recently published an article evaluating the cost-effectiveness of patent foramen ovale (PFO) management strategies, comparing closure with the Cardioform vs. Amplatzer device for seco...

Degeneracy-Aware Intensity-Assisted LiDAR–Inertial Odometry with Adaptive Photometric Weighting

LiDAR–inertial odometry (LIO) is accurate in structurally rich environments but can become weakly observable in tunnels, stairways, and open terrain. This study introduces a degeneracy-aware, intensity-assisted LIO method that uses LiDAR reflectivity as an internal sensing modali...

Finite-Resolution Quantum Gravity: Certified Integer-Length Causal Regge Ensembles, Exact Cutoff Composition, and an Executed Falsification Program

Finite-Resolution Quantum Gravity (FRQG) formulates a candidate theory of quantum gravity at finite cutoff as a family of amplitudes over time-oriented causal simplicial geometries whose invariant edge intervals are integer multiples of a fundamental resolution scale. The constru...

Putnam Problems Are Pedagogical, Not Unsolved Research Challenges — E8 Intelligence Research

FINDING: Putnam competition content is pedagogical, not research-level; no unsolved problems exist within the competition itself — the "unsolved" framing refers to broader Millennium Problems (Perelman/Poincaré) and general math expositions. | MATH: No novel equations or constant...

Delivering the Gut to the Brain: Drug Delivery Strategies for Microbiota-Derived Therapeutics in Depression

Major depressive disorder remains a leading cause of disability worldwide, and the limited efficacy and delayed onset of conventional antidepressants have intensified interest in the microbiota–gut–brain axis as a source of therapeutic targets. Microbiota-associated candidates—sh...

Image-aware mixture of experts automates the detection of ovarian follicle rupture in a high-throughput ex vivo ovulation assay

An AI-based dynamic, image-aware Mixture-of-Experts (MoE) framework automates ex vivo ovulation detection and offers a highly accurate, scalable solution for studying the biology of ovulation, drug development, and reproductive toxicity testing.

Iron oxide nanoparticles mitigate salinity stress in Ziziphora clinopodioides by enhancing growth, ion homeostasis, and essential oil content

Salinity is a major environmental constraint limiting the growth, physiological performance, and productivity of medicinal plants. This study investigated the effects of iron oxide nanoparticles (Fe₂O₃-NPs) and bulk ferric oxide on growth, ionic balance, oxidative stress, photosy...

Waveform-preserving source-independent wave-equation-based local-scale traveltime inversion: Application to the SEG Chevron 2014 blind test dataset

Summary Full Waveform Inversion (FWI) leverages the amplitude and phase of full wavefield seismic data to obtain high-resolution subsurface structures by minimizing an objective function. However, FWI encounters severe cycle-skipping issues when the seismic data lack low-frequenc...

Diversifying for resilience: how supply base international diversification relates to supply base sustainability performance

Abstract Recent work in international business views supply base international diversification (SBID) as an important strategy for strengthening multinational enterprises’ (MNEs’) resilience to country-level disruptions. However, it remains unclear how this resilience-oriented st...

Kinetics modelling of degradation process of organic pollutants in Ajali River Enugu, Nigeria

Kinetics and modelling of organic pollutants biodegradation in Ajali River was studied. Dissolved oxygen (DO) was determined using Winkler-Azide method, while biochemical oxygen demand (BOD) was determined after five days of incubation. Kinetic study was achieved using Streeter–P...

Machine‑learning prediction of skid resistance by British Pendulum Tester from 3D pavement surface texture: assessing the relative contributions of micro‑ and macrotexture

Skid resistance is strongly influenced by pavement surface texture, yet the texture–friction relationship is nonlinear and scale dependent. This study evaluates prediction of Pendulum Test Value (PTV) from 3D pavement-surface texture descriptors and quantifies the relative roles...

Mathematical Foundations of Constrained SO(3,3) Spacetimes: Part I. Isometric Embeddings and Topological Surgery

Multitemporal manifolds (e.g., SO(3,3)) are conventionally plagued by causality violations, pathological Cauchy problems, and the inevitable formation of closed timelike curves (CTCs). In this paper, we establish a rigorous differential geometric framework that resolves these pat...

Meta-regression model choice and the interpretation of trial-level surrogacy

The use of surrogate endpoints can improve feasibility of clinical trials. The results of trial-level analyses are a key factor affecting regulatory policy regarding the uptake of a surrogate endpoint. Trial-level analyses aim to quantify the strength of association between treat...

Geographic diversity in the OBGYN residency match – longitudinal comparison during virtual interview and signaling cycles

It is not well known how recent changes to the residency match process have impacted geographic diversity among residency matches. This study uses the Obstetrics and Gynecology match to evaluate how the recent changes, such as starting virtual interviews and the implementation of...

Seismic vulnerability and sustainable retrofit strategies for traditional masonry heritage buildings in Oman

Traditional masonry buildings constitute an important part of Oman’s architectural heritage; however, their seismic performance has received limited systematic attention despite the country’s exposure to regional and local seismic hazards. This study presents a qualitative assess...