Research works

Label‐Free YaxAB Nanopore Fingerprinting of Cancer‐Associated Single‐Residue Bcl‐xL Variants

Resolving cancer-associated protein variants remains difficult when variants share similar molecular masses and folded structures. Conventional assays often require labels or provide ensemble-averaged readouts, limiting their ability to resolve subtle variant differences. Here, a...

Inter-organisational Capabilities and the Transformation of Trust in Blockchain-based Smart Contracts: A Framework for SME Ecosystems

Blockchain-based smart contracts embed agreement enforcement within executable code, constraining the partner discretion that inter-organisational relationships (IORs) have traditionally coordinated through trust, communication, and relational governance. This raises a question t...

Conscientious objection to euthanasia: a qualitative study of palliative care physicians’ perceptions

Abstract Background Conscientious objection (CO) in healthcare is a pressing issue, particularly in euthanasia, where legal permissibility coexists with moral disagreement. CO is commonly framed as a principled refusal based on moral or religious convictions, often emphasizing te...

ReviewIQ: AI-Based Product Review Intelligence and Consumer Insight System Using NLP, Deep Learning, and Retrieval-Augmented Generation

This research paper proposes an AI Co-Founder system designed to support early-stage entrepreneurs in making informed business decisions. The system uses Retrieval-Augmented Generation (RAG), persistent company memory, semantic search, and external competitor intelligence to prov...

Muscle- and Gland-Specific Dosing of Botulinum Toxin in Facial Aesthetics: Review of Dose Ranges, Target Depth, Muscle Thickness, and Neuromuscular or Glandular Anatomy

Botulinum neurotoxin type A (BoNT-A) dosing in facial aesthetics varies across anatomical targets, formulations, and treatment indications. This structured narrative review examined published dose ranges and the potential relevance of muscle thickness, target depth, functional an...

Teachers’ Digital Competence for Multimodal Learning Environments: A Comparative Study Across Educational Levels in Galicia (Spain)

The assessment of teachers’ digital competence has become a key challenge for educational systems seeking to foster effective multimodal, online, and blended learning environments. This study examines the level of self-perceived digital competence and educators’ readiness to desi...

Molybdenum‐Enhanced Conductivity and Nickel Electron Density Synergizing With Phosphorus‐Induced Oxygen Vacancies in NiMo‐Based Heterostructures for Efficient Electrooxidation of 5‐Hydroxymethylfurfural

ABSTRACT 5‐Hydroxymethylfurfural (HMF) can be electrocatalytically oxidized to 2,5‐furandicarboxylic acid (FDCA) with concurrent hydrogen evolution, providing a sustainable route for biomass valorization and clean energy generation. In this study, we synthesized a three‐dimension...

Berberine as a Mitochondrial Metabolic Reprogrammer in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Adaptive Energetic Stress, Quality Control, and Translational Limitations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to mitochondrial dysfunction, including altered oxidative phosphorylation, disrupted fatty-acid oxidation, redox imbalance, abnormal mitochondrial dynamics, and impaired quality control. Berberine...

Multimodal Prodromal Patterns Associated with COPD Exacerbations in Home Telemonitoring: An Exploratory Observational Study

Characterizing multi-parameter physiological, acoustic, and environmental changes before acute chronic obstructive pulmonary disease exacerbations (AECOPD) is crucial for improving home telemonitoring and enabling timely clinical intervention. In a 12-month prospective observatio...

Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial

A common entrapment of median nerve that causes pain, numbness, and functional impairment is called Carpal Tunnel Syndrome (CTS). Laser therapy is a noninvasive intervention for neural repair and pain modulation, but comparative evidence between Low-Level Laser Therapy (LLLT) and...

On Conjecture 1 of Aldous for a Spatial Model of City Growth: A Proof of Part (a), and Counterexamples to Parts (b) and (c) for 2α/√3 < β < 2α

In rough notes of 2007 on a spatial model of city growth, D. J. Aldous stated a three-part conjecture about the unbalanced regime. Immigrants arrive one at a time at uniform random points of the unit square; a city of population n exerts the influence c0 n^α r^(−β) at distance r;...

Serial Cross‐Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric MRI and Histopathology

ABSTRACT Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non‐invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping...

Rapid Identification of Fritillaria Bulbus Botanical Origins and Adulteration by Thermal‐Assisted Plasma Ionization Time‐of‐Flight Mass Spectrometry Coupled With Chemometrics

ABSTRACT Fritillaria Bulbus (FB) is a valuable traditional Chinese medicine with diverse pharmacological activities. Due to economic incentives, high‐quality FBs are frequently adulterated with morphologically similar counterfeit species in commercial markets. A rapid analytical...

Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex

Importance Obesity is associated with elevated risks for multiple cancers. How bariatric surgery influences these risks across age and sex is insufficiently understood. Objective To evaluate the association between bariatric surgery and obesity-related cancer (breast, endometrial...

Deep learning-based profanity detection in social media: a survey in the context of toxic language detection

The spread of toxic and profane language across online platforms has necessitated the development of advanced automated detection systems to maintain safe online environments. This survey comprehensively explores the progression of profanity language detection techniques, focusin...

Gracilis Muscle Flap Reconstruction for Refractory Urethral Complications After Pelvic Surgery: A Report of Two Cases

ABSTRACT Introduction Iatrogenic urethral injury and rectourethral fistula are rare and challenging complications of pelvic surgery. Case Presentation Case 1 involved a 72‐year‐old man with persistent urinary leakage after primary repair of a prostatic urethral injury sustained d...

Imaging of Electrochemically Programmed Single-Molecule Reactions

Abstract Single-molecule reactions reveal intrinsic heterogeneity that is obscured in ensemble measurements. However, most existing approaches rely on extreme dilution, ultrasmall solution volumes, or physical confinement to keep individual events sufficiently sparse. Here, we in...

Foliar Biofortification of Lentil ( Lens culinaris Medik.) With Iron, Zinc, and Selenium: Multi‐Environment Evaluation in Bangladesh

ABSTRACT Micronutrient malnutrition remains a major global challenge, particularly in developing countries of South Asia, where diets are dominated by cereal‐based foods with low mineral content. Lentil is a nutrient‐rich legume with strong potential for biofortification to enhan...

The physician role in increasing patients adherence to the hypertension therapy: psychological and communicative aspects

The attending physician is a key factor in improving patient adherence to hypertension therapy, the extent to which a patient follows medical recommendations consciously and consistently depends largely on the clinician. Objective. To analyze studies and theoretical approaches re...

Infection Control Knowledge, Job Stress, and Self-Efficacy in Relation to Infection Control Performance Among Intensive Care Unit Registered Nurses: A Descriptive Cross-Sectional Study

Background/Objectives: Healthcare-associated infections remain a critical patient-safety concern in intensive care units (ICUs), where invasive procedures and immunocompromised patients elevate infection risk. Infection control knowledge, job stress, and self-efficacy have each b...