Research works

Ultrasound-guided stellate ganglion block enhances hemodynamic stability and postoperative recovery after laparoscopic myomectomy: a randomized controlled trial

To evaluate the effects of ultrasound-guided right stellate ganglion block (SGB) combined with propofol-based general anesthesia on perioperative hemodynamics, postoperative pain, recovery, and inflammatory stress responses in women undergoing laparoscopic myomectomy. In this sin...

A multilevel analysis of the predictive effects of internal migration and region of residence on women’s empowerment in Nigeria

BACKGROUND: Despite growing research interest on the influences of migration and regions of residence on human behaviors, studies on the influences of migration and region of residence on women empowerment especially in sub-Saharan Africa are lacking. Thus, this study investigate...

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

Road traffic injuries among older adults before and after a major earthquake: a single-center retrospective study

Road traffic injuries are a major cause of morbidity and mortality among older adults, frequently leading to prolonged hospitalization, functional decline, and loss of independence. Large-scale disasters, such as earthquakes, may act as important modifiers of mobility patterns an...

SNCA-targeted transcriptional repression therapy alleviates pathological and behavioral perturbations in a Parkinson's disease mouse model

Alpha-synuclein (SNCA) overexpression is implicated in Parkinson's disease (PD) pathogenesis, making SNCA downregulation a promising therapeutic strategy. We developed a SNCA -targeted transcriptional repression therapy using an all-in-one lentiviral vector (LV) carrying deactiva...

From international experience to global mindset: The contingent role of organizational context

Global mindset is widely recognized as essential for navigating cultural diversity and strategic complexity in multinational enterprises (MNEs). While prior research has identified individual factors influencing its development, less is known about how individual and organization...

Multi-omics analysis identifies the super-enhancer-driven gene NPW in left-sided obstructive lesions-associated cardiac remodeling

Left-sided obstructive lesions (LSOLs), represented by coarctation of the aorta (CoA), cause persistent vascular pathology and pressure overload that can lead to pathological cardiac remodeling. However, the epigenetic changes associated with local vascular abnormalities and vent...

Homogenizer-assisted dispersive liquid-liquid microextraction followed by ion mobility spectrometry for the fluconazole determination in real samples

This study developed a new method based on homogenizer-assisted dispersive liquid-liquid microextraction (HA-DLLME) followed by ion mobility spectrometry (IMS) for determining fluconazole in different samples. A homogenizer was used to disperse the extraction solvent, which has t...

Long-term outcomes of hemithyroidectomy in unexpected hereditary medullary thyroid cancer: a nationwide observational study

Total thyroidectomy (TT) is the standard surgical approach for hereditary medullary thyroid cancer (hMTC). However, it is not rare in clinical practice for patients with hMTC to initially undergo hemithyroidectomy (HT) because the hereditary nature of the disease is not recognize...

Optimal strategies for pancreatic stump management in distal pancreatectomy: A network meta-analysis of randomized controlled trials

Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following distal pancreatectomy (DP). Despite numerous randomized trials evaluating stump closure and reinforcement techniques, the optimal strategy remains uncertain. We conducted...

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...

Adult lupus anticoagulant hypoprothrombinemia syndrome with combined factor II and X deficiencies: diagnostic and therapeutic challenges

Background: Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare, acquired coagulopathy characterized by the presence of lupus anticoagulant and deficiency of factor II, causing paradoxical bleeding despite prothrombotic antibodies. LAHPS may cause falsely low INR v...

Threshold-window framework reveals management-sensitive controls of CH4 and N2O emissions in flooded rice

Rice paddies are major sources of methane (CH 4 ) and nitrous oxide (N 2 O), yet co-managing water and nitrogen (N) to limit both gases remains challenging because emissions arise from non-linear interactions among multiple drivers. We combined a two-year field experiment in subt...

Virological surveillance of chikungunya in Burkina Faso in 2024

Chikungunya is an emerging arbovirus disease transmitted by mosquitoes of the genus Aedes , mainly Aedes aegypti and Aedes albopictus . Since it was first identified in Tanzania in 1952, the virus has caused numerous epidemics around the world. Despite arbovirus surveillance sinc...

Nano-boosted green coffee bean extract cream for enhanced anti-cellulite topical therapy: A randomized clinical trial

Cellulite is a prevalent cosmetic concern among postpubertal women, and the efficacy of conventional topical therapies remains limited. Green coffee bean extract (GCBE) exhibits antioxidant and lipolytic activities relevant to cellulite management; however, its topical performanc...

Class- and dose-dependent heterogeneity in the risk of medication-related osteonecrosis of the jaw among antiresorptive agents: a nationwide new-user cohort study using Korean National Health Insurance claims data

Antiresorptive agents are widely used to treat osteoporosis and skeletal complications of malignancy, but long-term use can lead to medication-related osteonecrosis of the jaw (MRONJ). No nationwide Korean study has directly compared oral and intravenous bisphosphonates with low-...

An energy-saving strategy for edge data center clusters driven by deep learning and real-time load forecasting

To address energy-saving optimization in edge data center clusters under high-density cabinet deployment, dynamic workload fluctuations, and increasingly strict energy-efficiency constraints, this paper proposes a collaborative energy-saving strategy driven by deep learning and r...

Impact of noncommunicable diseases (NCDs) on COVID-19 mortality: A study of risk factors and outcomes in a Southeast Asian population

This study investigated the association between noncommunicable disease (NCD) comorbidities and clinical outcomes of COVID-19 infection, and examined the effects of demographic factors, vaccination status, and symptom presentation on COVID-19 disease fatality in Brunei Darussalam...

An explainable machine learning model based on quantitative HRCT parameters for identifying bronchoscopically confirmed airway stenosis in tracheobronchial tuberculosis

Airway stenosis is a frequent and serious complication of tracheobronchial tuberculosis (TBTB), leading to chronic airflow obstruction and reduced quality of life. However, no individualized predictive model currently exists to assess airway narrowing risk in these patients. This...

Bilateral internal carotid artery dissection and occlusion in Eagle syndrome treated with emergency single-session bilateral carotid artery stenting: a case report

Eagle syndrome (stylocarotid variant) is a rare but potentially life-threatening cause of internal carotid artery (ICA) dissection and ischemic stroke. Bilateral ICA dissection due to Eagle syndrome has been treated with both staged and single-session bilateral carotid stenting e...