Research works

Integrated prognostic framework for survival status, Cancer stages and time estimation in hepatocellular carcinoma using machine learning approaches

Current medical limitations in assessing cancer survival status, stage, and duration necessitate advancements beyond physical indicators and conventional diagnostic techniques. Improving the quality of patient treatment is an ongoing objective of the medical community. Accurate p...

Five-year survival and prognostic factors of cervical cancer (stages I-IV) in Rwanda: a population-based analysis, 2017–2021

Cervical cancer remains a leading cause of cancer-related mortality among women in low- and middle-income countries. This study assessed five-year survival and prognostic factors among patients diagnosed with cervical cancer in Rwanda. We conducted a population-based retrospectiv...

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

BACKGROUND: KRAS G12C-mutant advanced non-small cell lung cancer (NSCLC) is currently treated with KRAS G12C covalent inhibitors, such as sotorasib, or RAS (ON) G12-selective inhibitors; however, response rates and progression-free survival remain limited, with recurrence occurri...

A Parity Lock in Modulo-Based Evolution Criteria: An Ablation Study of the Reflection Loop in an Organic Coupling Architecture (Technical Report)

In a self-referential learning system (Demian Nucleus v15), hidden-layer evolution is gated by the condition total mod 10 = 0. We run three ablation conditions (control, ablate, perturb) and find that silencing the reflection loop causes evolution to halt permanently after a prun...

Deoxynivalenol-induced intestinal toxicity in piglets is mediated by multi-kingdom microbial dysbiosis and metatranscriptomic reprogramming

Mycotoxin contamination of feed and food, particularly with deoxynivalenol (DON), poses significant threats to intestinal health in livestock, yet the role of gut fungi (mycobiota) and fungal-bacterial interactions remains unclear. Across four piglet experiments integrating multi...

Single-blastomere next-generation sequencing confirms chromosomal abnormalities as the primary cause of impaired developmental potential in embryos with abnormal cleavage patterns

Abnormal cleavage impairs embryonic development, but the effects of different abnormal cleavage patterns and occurrence stages remain unclear. Previous chromosomal analyses at the blastocyst stage have failed to elucidate the underlying mechanism. This study investigated the effe...

The interaction effect of health expenditure and institutional quality on maternal and child health in Nigeria between 1978 and 2023

Poor budget allocation has been identified as one of the reasons for poor health outcomes in Nigeria. Recently, government expenditure on the health sector has increased across all tiers of government to enhance health service deliveries. However, the performance of health indica...

Robust PV fault diagnosis under data constraints using a hybrid vision transformer with cross-attention fusion and uncertainty-aware explainability

Solar photovoltaic (PV) systems are crucial in modern energy infrastructures for the shift to sustainable renewable energy, making accurate and reliable fault diagnosis essential for maximizing energy yield, operational efficiency, and system availability. However, reliable autom...

From Exactness to Decidability: The 2026 Conservativity Requirement

CENTRAL STATEMENT For the first time in this framework, the decisive question is not whether a representation is formally correct, but whether it is sufficient for the task and that question is operationally decidable. What has traditionally been treated as an epistemological que...

Novel customized 3D-printed prosthesis for complex infected bone defects: a clinical case series

Infected bone defects, especially irregular or long-segment defects, pose great clinical challenges. By performing bone defect reconstruction on patients with complex infected bone defects admitted to our hospital, this study explores the clinical efficacy of a novel customized 3...

Clinical outcomes of minimally invasive liver resection in patients with cirrhosis: A systematic review and meta-analysis

Backgrounds/Aims: The impact of cirrhosis on outcomes following minimally invasive liver resection (MILR) remains debated. This meta-analysis evaluates the effect of cirrhosis on perioperative outcomes in patients undergoing MILR. Methods: PubMed, Embase, CINAHL, Scopus, and Web...

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...

Simultaneous determination and ADME profiling of betulinic and ursolic acids from Avicennia marina in Wistar rats

Avicennia marina (grey mangrove) (AM) is a significant source of bioactive pentacyclic triterpenoids, specifically Betulinic acid (BA) and Ursolic acid (UA). Owing to their therapeutic potential, the pharmacokinetic (PK) profiles of these bioactives after administration of AM ext...

Association between adherence patterns to antifibrotic therapy and survival in fibrotic interstitial lung disease: a nationwide Austrian health claims study

Antifibrotic therapies slow disease progression in patients with progressive fibrosing interstitial lung diseases (PF-ILD). However, long-term adherence is difficult to maintain mainly due to side effects. Real-world data on adherence and its association with prognosis are still...

Targeting CD38 Across Autoimmune and Plasma Cell–Driven Immune-Mediated Diseases: Rationale, Clinical Evidence, and Emerging Therapeutic Landscape

Autoimmune diseases remain a major cause of chronic morbidity despite substantial advances in targeted immunomodulatory therapies. In many autoantibody-mediated conditions, disease refractoriness and relapse are driven by long-lived plasma cells, which are largely resistant to co...

The relationship between the uric acid to prealbumin ratio and frailty, muscle strength, and malnutrition risk in older geriatric outpatients: a retrospective cross-sectional study

Frailty, sarcopenia, and malnutrition are common in older adults; however, simple biomarkers reflecting both inflammatory and nutritional status remain limited. We aimed to evaluate the relationship between the uric acid-to-prealbumin ratio (UPR) and frailty, muscle strength, and...

Multimedia fate and transport simulation for green synthesized zero valent iron nanoparticles using SimpleBox4nano

Green synthesized zero valent iron nanoparticles (nZVI) are promoted as environmentally benign alternatives to chemically synthesized ones. Simulation models are used to predict nZVI transport and transformation during environmental remediation. The objective of this study was to...

Comparison of estimated personalized treatment rules under varying interference structures and treatment rates using dynamic weighted ordinary least squares

Dynamic treatment regimes (DTRs) are statistical methods that use patient-specific information to estimate an optimal sequence of treatments, with the end goal of maximizing a desired outcome of interest. DTRs have many useful applications to chronic disease management when patie...

Atypical CTPA contrast timing revealing a suspected right-to-left shunt in a patient with advanced COPD and concurrent pulmonary malignancy

Hypoxemia in chronic obstructive pulmonary disease (COPD) typically arises from ventilation-perfusion (V/Q) mismatch. However, refractory hypoxemia should raise concern for alternative mechanisms, such as intracardiac shunting. This report describes a rare presentation where a ca...

Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing

<p dir="ltr">Objective</p><p dir="ltr">To evaluate the clinical utility of incorporating a type 1 diabetes genetic risk score (T1DGRS) into monogenic diabetes gene panel testing for individuals referred with suspected maturity-onset diabetes of the young (MODY)...