Research works

Investigation into the transforming mechanism from flash-to-conventional drought in different soil moisture layers in a highly climate-diverse basin

Study region The Indus Basin, a highly diverse climate basin in South Asia. Study focus The transformation from flash drought to conventional drought (FD-CD) poses significant challenges to drought risk and management systems, necessitating a comprehensive assessment of the dynam...

Forward‐looking breakeven cattle feeding conditions in futures markets

Abstract This study uses cointegration analysis and a vector error correction model to determine the long‐run cointegrating equation among feeder cattle, corn, and live cattle futures prices. Assuming that the cointegrating equation is reflective of breakeven conditions in cattle...

Integrative Multi-Database Bioinformatics Characterization of FANCE in Hepatocellular Carcinoma: Prognostic, Epigenetic, Immune, and ncRNA Associations

Background and Objectives: The Fanconi anemia complementation group E (FANCE) is a protein component of the Fanconi anemia (FA) DNA repair complex and contributes to genome integrity. However, its molecular and clinical relevance in liver hepatocellular carcinoma (LIHC) remains i...

Challenges in Learning Continuity during the COVID-19 Pandemic: A Methodological and Thematic Review

The COVID-19 pandemic has resulted in the physical closure of educational institutions throughout the world, but learning continues, albeit with a paradigm shift. The use of digital content in the teaching-learning process gradually began shifting from erstwhile intermittent tech...

GAMEMANCIPATION NOW! An intergenerational framework for evaluating games as participatory tools in architecture and urban planning

Games are increasingly used in architecture and urban planning to support participation, learning, and co-design, yet evaluation remains uneven: studies often report engagement and dialogue while less consistently assessing power relations, agency, and whether game outputs transl...

Surgical Success in Obstructive Sleep Apnea Patients Using Preoperative Drug‐Induced Sleep Endoscopy and Awake Endoscopy Considering Disease Severity

ABSTRACT Background Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent episodes of airway obstruction during sleep, leading to fragmented sleep and oxygen desaturation. Identifying the precise site and pattern of obstruction is essential for surgical...

Effect of Sevoflurane, Propofol, and Remifentanil on Hemodynamic Response to Pneumoperitoneum and Laparoscopic Surgery: A Randomized Controlled Trial

BACKGROUND: Although the interaction of sevoflurane, propofol, and opioids has been investigated regarding motor response to laryngoscopy, their hemodynamic impact during surgical stimulation remains unexplored. We therefore assessed the effect of sevoflurane, propofol, and remif...

Attributing Electricity-Related Greenhouse Gas Emissions to Real Water Losses in Greek Water Utilities Using Regulatory Reporting Data

Water lost from distribution networks has already consumed electricity, but the associated greenhouse gas burden is rarely quantified, because water balances and organizational emission inventories use different boundaries. This study links the two within the Greek managerial-ade...

Faster immobilization and recovery with remimazolam compared to midazolam in medetomidine–butorphanol balanced anesthesia in male Sprague–Dawley rats: a randomized crossover study

Abstract Background Balanced injectable anesthesia combining an α2-adrenoceptor agonist, a benzodiazepine, and an opioid is widely used in laboratory rodents because it provides sedation, muscle relaxation, and analgesia through complementary pharmacological mechanisms. In Japan,...

Benchmarking sex ratio at age zero as a data quality indicator for small populations: Using census 2000 as a case study

Sex ratio at birth is one of the simplest tools for evaluating the quality of population data on sex, but its usefulness as a quality-control indicator depends on knowing how much deviation from the expected value is normal statistical noise versus a genuine data problem. This pa...

Next-generation CDK inhibitors in HR+/HER2– breast cancer

Cell-cycle dysregulation is a central driver of breast cancer progression and a major therapeutic vulnerability, particularly in hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR + /HER2 – ) disease. The clinical success of cyclin-dependent kinase (C...

Phenolic Metabolites as Therapeutics for Chronic Diseases: One Researcher’s PAINS Is Another’s Translatable Polypharmacology

Abstract Phenols, natural and semisynthetic compounds in which a hydroxylated or oxygenated aromatic scaffold is a defining structural feature, occupy a paradoxical position in drug discovery. On the one hand, these compounds are frequently scrutinized for triggering Pan-Assay IN...

Predictive Role of Maternal Mid-Gestational Inflammatory Biomarkers in Preterm Birth: A Prospective Cohort Study

Spontaneous Preterm birth is a leading cause of neonatal complications, primarily driven by inflammatory processes. This is the 1st study involving pregnant women in Pakistan to examines the relationship between elevated mid-gestational levels of serum inflammatory markers and th...

Mechanical strengthening and fracture surface morphology of sustainable epoxy composites reinforced with tamarind seed powder

The main objective of this work is to experimentally evaluate the physical and mechanical characteristics of an epoxy/tamarind seed powder (TSP) composite by varying the TSP composition at 0%, 5%, 10%, 15%, and 20% by weight. TSP is added as a novel sustainable bio-filler in epox...

Cross‐Phase Impurity–Interphase Regulation for Suppressing Thermally Accelerated Failure in Ni‐Rich Pouch Lithium‐Ion Batteries

ABSTRACT Practical LiNi 0.8 Co 0.1 Mn 0.1 O 2 ||graphite pouch cells suffer rapid degradation under thermal stress because liquid‐phase impurity reactions, electrode interphase failure, and cathode–anode cross‐talk are tightly coupled. However, most strategies are designed to add...

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

TFEB drives ER stress-induced apoptosis and limits cyst growth in polycystic kidney disease

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts and loss of renal function. Here, it was demonstrated that transcription factor EB (TFEB) activation in cyst-lining epithelial cells enhances their susceptibili...

Coupling Luciferase Activation and Bioluminescence Resonance Energy Transfer Enables High-Contrast Red-Window Calcium Imaging

Abstract Genetically encoded bioluminescent calcium indicators enable excitation-free imaging of Ca2+ dynamics with low background and without excitation-associated photobleaching. However, many exhibit lower dynamic ranges than their fluorescent counterparts, motivating the deve...

Monograph 34: Voluntary Civic Self-Governance and Low-Entropy Public Infrastructure (Including Addendum A: The Law of General Understanding)

This monograph presents a civil-systems framework for reducing administrative, legal, and operational friction in modern public and managed residential spaces. By establishing a proactive "Ladies and Gentlemen" civic posture rooted in personal accountability, empathy, and mutual...

Psychometric analysis of an intersectional stigma scale for women who have experienced intimate partner violence in Botswana

Intimate Partner Violence (IPV) is pervasive in Botswana. IPV stigma may affect the mental health of women survivors. We developed and validated a new scale for intersectional stigma for women who experienced IPV in Botswana. We used a known-groups design. With interviews held in...