Research works

Longitudinal Changes in Pituitary Area in Individuals Undergoing Magnetic Resonance Imaging Checkups

Background: The aim of the study was to investigate longitudinal changes in pituitary area and their associations with baseline characteristics and lifestyle factors in individuals undergoing brain magnetic resonance imaging (MRI) checkups. Methods: A retrospective analysis was p...

Topic Modeling-Based Analysis of Research Trends in Dementia Studies: 2000~2025

치매정책과 사회적 담론에 직·간접적인 영향을 미치는 치매연구는 예방, 진단, 치료 및 생활 지원 등 다양한 측면에서의 접근이 필요하다. 국내 치매연구의 양과 질이 빠르게 증가하는 가운데 그동안의 연구 주제의 변화를 살펴보는 것이 필요하다. 본 연구에서는 2000년 이후 2025년 4월 30일까지 RIS...

Median effective infusion rate (ED50) of continuous cisatracurium for preserving interpretable TceMEP signals during intraspinal tumor resection: a prospective up-and-down sequential allocation study

Intraoperative neurophysiological monitoring (IONM), particularly transcranial electrical stimulation motor evoked potentials (TceMEP), plays a crucial role in preserving motor function during intraspinal tumor resection. However, neuromuscular blocking agents (NMBAs) may attenua...

Development and external validation of a nomogram for overall survival in oral tongue squamous cell carcinoma using machine learning-assisted feature selection

This study aimed to identify prognostic factors using machine learning-assisted feature selection and develop a Cox-based nomogram for predicting 2-year and 5-year overall survival in Oral Tongue Squamous Cell Carcinoma (OTSCC). Clinical data from 5746 OTSCC patients in the SEER...

Induction of interleukin-6 by anti-ribosomal P protein immunoglobulin G3 autoantibody in monocytes through Fcγ receptor cross-linking

Kaho Sato, M.D., Hiroe Sato, M.D., Ph.D., Tomoya Watarai, M.D., Ayako Wakamatsu, M.D., Ph.D., Daisuke Kobayashi, M.D., Ph.D., Suguru Yamamoto, M.D., Ph.D., Yoshikatsu Kaneko, M.D., Ph.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2026.0017

P1D6 inhibits FnBP-induced extracellular proteome remodeling: proteomic evidence for a novel intervention strategy in atopic dermatitis

Atopic dermatitis (AD) is an inflammatory skin disorder characterized by skin barrier impairment, chronic inflammation, and intense pruritus. Staphylococcus aureus ( S. aureus ) critically contributes to its pathogenesis; however, the mechanistic role of its virulence factor fibr...

A conserved miR-7132a/SOCS1/STAT2 regulatory axis enhances type I IFN antiviral responses in teleost fish

Type I interferon (IFN) signaling plays an essential role in restricting viral infection. Accumulating evidence indicates that microRNAs (miRNAs) serve as key regulators of the type I IFN signaling in mammals. However, whether the miRNA-mediated regulation is involved in type I I...

Three-dimensional spatio-temporal propagation dynamics from soil moisture to vegetation droughts across different eco-geographical regions of China

Study region China. Study focus This study investigated the propagation from soil moisture drought (SD) to vegetation drought (VD) across China during 1981–2020 using a three-dimensional (3-D) spatio-temporal clustering framework. SD and VD events were identified based on the Sta...

Passive sampling reveals composition of airborne bacteria and fungi across five East African cities

Airborne microbes significantly influence environmental processes and human exposure, yet they remain poorly characterized in Africa. This study presents a regional survey of airborne bacterial and fungal communities across 10 sites in five East African countries: Burundi, the De...

CantataS: a Community-aware agent-based citation Simulator

Early preprint describing CantataS, a generative agent-based model of citation dynamics that builds upon the PyABM, SASCA, SASCA-s, SASCA-ReS, and SASCA-ReSA models. This preprint is likely to be updated several times as more data is generated through simulations under the Cantat...

The Picken Complete Taxonomy for AI Governance: A Unified Instrument Framework for Board-Level AI Governance Assessment, Liability Pricing, and Sector Contagion Modelling

AI governance research has, to date, developed largely as a series of independent instruments, each addressing a discrete failure mode — regulatory exposure, vendor credibility, sector-specific liability — without a unifying framework describing how these instruments relate to on...

"From Innovation to Market" White Paper

As part of the Security Mission Information & Innovation Group (SMI2G) event, held on 23–24 April 2026 at the Conseil régional d'Île-de-France, Paris, France, the panel discussion "From Innovation to Market" brought together panellists who shared their experience in research and...

Cogenesis: Causal Singularity of Now

This document presents Cogenesis as both a universally relational ontology and a predictive physical theory. Relation entails environment: space is the unlimited relational availability within which distinction, expression, and persistence occur, while geometry, metric, dimension...

Study on Subcellular Expression Patterns of p62/SQSTM1 in Oral Squamous Cell Carcinomas: An Immunohistochemical Analysis

ABSTRACT Background p62/SQSTM1 is a multifunctional 62 kDa protein that shuttles between the nucleus and cytoplasm to maintain protein homeostasis through the autophagy machinery. Dysregulated p62 acts as an oncogenic signalling hub, activating pathways such as NF-κB, Nrf2, and m...

Exploring the Relationship Between Body Mass Index and Prostate Cancer Incidence: A Comprehensive Systematic Literature Review

Prostate cancer is the second leading cause of male cancer-related mortality in the United States, with an estimated 299,010 new cases and 35,250 deaths expected in 2024. This systematic literature review aims to explore the relationship between body mass index (BMI) and prostate...

Institute Research Agenda V1.2

opened at Institute launch V. 1.2: Adds Programme H (Title-Location Atlas).

Reconstructing Journal Thematic Identity from Article-Level Topics: A Reproducible Framework and a Preregistered Temporal Validation

Journals are conventionally described by editorial subject classifications, yet what a journal actually publishes need not coincide with its assigned label. We present a framework for reconstructing a journal's thematic identity from article-level evidence while maintaining a str...

Structural analysis of the signless Brouwer conjecture: projection thresholds, extremal families, and the Laplacian–signless gap

We study the signless Brouwer conjecture (Ashraf–Omidi–Tayfeh-Rezaie): the inequality S_k(Q) ≤ m + C(k+1,2) for the sum of the k largest eigenvalues of the signless Laplacian Q = D + A of a graph with m edges, where C(k+1,2) denotes the binomial coefficient (k+1)(k)/2. We develop...

Isometric bending discriminates intrinsic from extrinsic curvature coupling of nematic order in skin

Oriented structures in skin — hair and feather follicle axes, collagen bundles, elongatedepithelial cells — can be coarse-grained into a tangential nematic order parameter on acurved surface. Such a field couples to geometry in two physically distinct ways: intrinsically,through...

The Limits of Sacred Authority: Consent, Withdrawal, and Non-Imposition in Religious Jurisdiction

Religious traditions may teach exclusive doctrines, organize rites, credential specialists, control offices and membership, refuse recognition, and end association. This paper does not decide whether the individual, lineage, community, ancestral line, or land is the primary beare...