Research works

Melittin Attenuates Against Circadian Rhythm Disruption-Induced Hepatic Injury Through Antioxidant and Anti-Inflammatory Effects

Background Circadian rhythm disruption (CRD) is a risk factor for metabolic and hepatic disorders. This study aimed to investigate the potential hepatoprotective effects of melittin against liver injury induced by constant light exposure in a rat model. Materials and methods Twen...

A Case of Tracheal Stent Placement under Extracorporeal Membrane Oxygenation for Airway Stenosis Caused by Subcarinal Lymph Node Metastasis from Muscle-Invasive Bladder Cancer

症例は64歳，女性。泌尿器科にて筋層浸潤性膀胱癌の治療後で，当科で非結核性抗酸菌症にて通院中であった。経過中に湿性咳嗽と喘鳴があり，吸入ステロイド薬/長時間作用性β2刺激薬配合剤およびステロイド点滴投与を行った。しかし呼吸困難感が増強し胸部CTを撮影したところ，径30 mmの気管分岐部リンパ...

Correlation between clinical communication competence and transition shock among new nurses: a cross-sectional study

New nurses face severe transition shock when entering clinical practice. Clinical communication competence is one of the essential competencies for clinical nurses and is crucial to the quality of nursing care. However, this competence is affected by various factors, and relevant...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...

Molar incisor hypomineralisation: a cross-sectional study of knowledge, clinical decision-making, and the influence of clinical experience in aesthetic and restorative dental practice

Molar incisor hypomineralisation (MIH) presents considerable diagnostic and restorative challenges in clinical practice due to its heterogeneous clinical presentation and compromised enamel structure. The present study aimed to evaluate MIH-related knowledge, confidence, and clin...

Prevalence and incidence of dementia with Lewy bodies using current McKeith diagnostic criteria (2017–2020): a population-based study

Dementia with Lewy bodies (DLB) is one of the most common neurodegenerative dementias in older adults but remains frequently underdiagnosed in routine clinical practice. Epidemiological data are limited and heterogeneous, and only a small number of population-based studies have a...

Structure Identification and Compression Behavior Analysis of 3D Fibrous Networks via Persistent Homology

Three-dimensional fibrous networks combine high porosity with a characteristic nonlinear J-shaped compressive response, yet the topological origins of this stiffening behavior remain elusive due to the complexity of their random architecture. Here we investigate the structural me...

Evaluation of the quality and reliability of YouTube videos as a source of information on oral health during pregnancy: a cross-sectional content analysis

This study aimed to evaluate the content quality, reliability, and informational value of YouTube videos regarding oral and dental health during pregnancy, while examining the correlation between quality, source type, and user engagement metrics (e.g., number of views, likes, and...

ECT/18F-FDG PET-CT for myocardial viability assessment during VA-ECMO support in AMI-related cardiogenic shock: a case series and literature review

Weaning patients from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) after acute myocardial infarction-related cardiogenic shock (AMI-CS) depends on whether the injured left ventricle can recover. Cardiac magnetic resonance imaging is often impractical during ECMO su...

A Survey of Community Pharmacists’ Perceptions and Issues Regarding the Indiscriminate Long-Term Use of Proton Pump Inhibitors

Proton pump inhibitors (PPIs) are classified as potentially inappropriate medications for older adults. Indiscriminate long-term use of PPIs after symptom resolution (indiscriminate PPIs) may increase the risk of adverse events and healthcare costs, emphasizing the need for appro...

Longitudinal Changes in the Blood Urea Nitrogen-to-Creatinine Ratio After Initiation of Abemaciclib: A Single-Center Retrospective Observational Study

Serum creatinine (Cr) elevation is frequently observed after the initiation of abemaciclib treatment. Because abemaciclib inhibits tubular creatinine secretion, Cr may increase without a true decline in glomerular filtration rate. In Japan, cystatin C is not routinely measured in...

Data-driven Physical Adjustment for Nonlinear Motion Tracking

Multiple object tracking in real-world pedestrian scenes is often degraded by false positive detections and unstable prediction-detection alignment arising from object proximity, partial occlusion, and overlapping motion. These factors can disrupt data association and lead to ina...

Crowe severity and femoral stem geometry are associated with lower-limb alignment after total hip arthroplasty for unilateral developmental dysplasia of the hip–related secondary osteoarthritis: valgus alignment trajectories

BACKGROUND: Total hip arthroplasty (THA) for secondary osteoarthritis related to developmental dysplasia of the hip (DDH) restores hip mechanics. We aimed to quantify pre-to-postoperative changes in ipsilateral knee and global lower-limb alignment after unilateral THA to determin...

Antibiotic susceptibility of genital tract isolates in pregnant women with premature pre-labour rupture of membranes (PPROM) in a low-resource setting

Premature pre - labour rupture of membranes (PPROM) is a significant obstetric complication that contributes to preterm births, maternal infections, and neonatal morbidity. The role of genital tract infections in the etiology of PPROM is well established, yet data on microbial is...

Health effects associated with emissions from household generators used for backup power in Africa: a scoping review

In many low- and middle-income countries, unreliable electricity supply has led to widespread reliance on petrol (gasoline) and diesel generators. The type of fuel influences both the quantity and composition of emissions, which contribute substantially to air pollution and pose...

Robust Image Processing Techniques for Construction Environment Monitoring Using Underwater Robots

This study proposes a robust image processing framework for underwater robot-based construction environment monitoring, targeting complex degradations observed in actual marine environments. Unlike conventional approaches that mainly consider absorption and backscattering, real u...

A Service Pressure Index (SPI) for quantifying service pressure in India’s public oral health system and its implications for curative care and Public Health Dentistry

Public oral health services in India show a persistent mismatch between nominal workforce availability and effective service delivery. Despite infrastructure and sanctioned posts, care remains predominantly symptomatic, indicating underlying system level constraints. Conventional...

Three Gorges Dam-driven redistribution, sediment-water partitioning, and health risks of heavy metals in the Yangtze River

The Three Gorges Dam (TGD), the largest hydraulic project on the Yangtze River mainstream, has altered hydrodynamic regimes and sediment transport. However, how its interplay with basin-scale pollution control policies regulates heavy metal behavior remains poorly understood. The...

Reliability and diagnostic performance of radiologic indices of the proximal humerus in evaluating bone mineral density: a retrospective study

Proximal humerus fractures (PHFs) are the third most common osteoporotic fractures. Assessment of bone mineral density (BMD) is clinically relevant in patients with PHFs. Several studies have proposed the use of radiologic indices, including the average cortical bone thickness (C...

Structural Safety Evaluation and Co-simulation-based Control Verification of a Mobile Robot for Ship Block Pretreatment

The pretreatment process in shipbuilding is essential for ensuring coating quality but involves hazardous working conditions, necessitating the introduction of automated systems. However, conventional automation systems have limitations in navigating the complex, unstructured int...