Research works

A Novel Methodology for Temporal Analysis of Consumer Wearable Sleep Data: Feasibility and Application to Early Cognitive Impairment

While sleep disturbances are recognized as early markers of Alzheimer's disease (AD), the practical application of gold-standard polysomnography (PSG) for long-term monitoring is limited. This study aims to establish a novel methodological framework for the time-series analysis o...

Comparative phytotoxicity of PFOS and its substitute OBS in mulberry and implications for a mulberry-silkworm exposure system

Perfluorooctane sulfonic acid (PFOS) is a persistent perfluoroalkyl substance known to exert adverse effects on soil and terrestrial ecosystems. However, the toxicological risks of its substitutes, particularly sodium p-perfluorinated nonenoxybenzene sulfonate (OBS), and their im...

Suspected donor-vessel ischemia in a collateral-dependent right coronary artery occlusion presenting as a de Winter-like pattern with inferior ST-segment elevation: a case report

The de Winter electrocardiographic pattern is a recognized equivalent of ST-segment elevation myocardial infarction and is most commonly associated with acute left anterior descending artery ischemia. Its coexistence with overt ST-segment elevation in another territory is uncommo...

Concurrent chemoradiotherapy for metastatic vulvar extramammary Paget’s disease involving supraclavicular nodes: a case report

Extramammary Paget's disease (EMPD) is a rare adenocarcinoma with a poor prognosis when invasive.Here, we report an exceptionally rare case of invasive vulvar EMPD in a 70-year-old woman who presented with extensive lymphadenopathy involving the inguinal, pelvic, para-aortic, and...

Effects of monensin residues on microbial community and the attenuation of antibiotic resistance genes during chicken manure composting

Monensin is a polyether ionophore antibiotic widely used to prevent coccidiosis and inhibit Gram-positive bacteria. Composting is widely regarded as an effective strategy for reducing the abundance of antibiotic resistance genes (ARGs) in manure. However, the long half-life of mo...

Mode of diagnosis of metastatic breast cancer recurrence and survival: a retrospective study

Randomized studies failed to show a survival benefit for screening asymptomatic breast cancer (BC) survivors for metastases, however, their relevance to the era of modern systemic therapies is unknown. Socioeconomic status (SES) may confound the association between mode of diagno...

Design and synthesis of 6-chloro-1,3,5-triazine-2,4-diamine linked chalcone derivatives and their antimalarial activity evaluation

A series of nine triazine-chalcone hybrid compounds (7a–i) were designed and synthesized through a molecular hybridization strategy integrating 1,3,5-triazine and chalcone moieties. The hybrids were synthesized via sequential nucleophilic substitution reactions and characterized...

Vegetative Barrier Acts as a ‘Trapper’ Rather than a ‘Filter’ for Potentially Toxic Element Contaminated Wind-Erodible Particles at the Vicinity of an Industrial Brownfield: Evaluation of a Nature-Based Solution

Brownfields can represent sources of multiple contaminants and may present health risks through airborne particle dispersion and incidental soil ingestion for surrounding populations. Remediation with nature-based solutions to mitigate legacy industrial pollution is therefore a r...

Precision switching from entecavir to tenofovir alafenamide in chronic hepatitis B: matching the patient phenotype to efficacy, safety, and value: a narrative review

Switching patients who are virologically stable with chronic hepatitis B from entecavir to tenofovir alafenamide has become routine in Korea; however, the literature has established whether switching works at the population level rather than at the patient level. This review refr...

A multi-database machine learning approach to predict depression and frailty in elderly populations with chronic conditions

Depression and frailty frequently co-occur in older adults with chronic disease, significantly impairing physical and psychological health; however, their bidirectional association remains unclear. Data from four large population-based cohorts—CHARLS, HRS, KLOSA, and SHARE—were c...

School leadership for improvement through resource allocation and infrastructure development in rural schools

Effective school improvement in resource-constrained settings depends on leadership that navigates persistent structural limitations, yet empirical evidence from rural Ethiopia remains scarce. This study contributes to Sustainable Development Goal 4 (SDG 4) by examining how leade...

Magnetization Reversal by Electric Field in Co-substituted BiFeO3

Electric-field control in multiferroic materials is attracting attention for next-generation memory devices with low power consumption and non-volatility. This review overviews magnetization reversal in cobalt-substituted BiFeO3 (BiFe1－xCoxO3), a single-phase room-temperature mu...

A triple-responsive smart controlled-release system for antifungal volatiles: toward sustainable agriculture via pathogen-targeted control and crop growth promotion

Fungal contamination causes substantial global food loss and waste. Among these, tomato gray mold caused by Botrytis cinerea is particularly severe, leading to a global reduction in tomato yield of 10–50%. Meanwhile, the overuse of conventional chemical fungicides has triggered a...

High 28-day mortality in resistant gram-negative bloodstream infections in the ICU: retrospective cohort study

Hospital-acquired bloodstream infections (BSI) caused by carbapenem-resistant and difficult-to-treat resistant (DTR) Gram-negative bacteria are a global threat associated with high mortality in (ICUs). The aim of this study was to evaluate 28-day mortality, independent risk facto...

SNP genotyping in Pseudotsuga menziesii and Pinus radiata using targeted genotyping-by-sequencing (GBS): improved Bayesian SNP calling using a beta-binomial distribution and other optimized input parameters

Single-nucleotide polymorphism markers (SNPs) have important applications in gene conservation, breeding, and fundamental genetics research. Our long-term goal is to develop routine approaches for SNP genotyping in forest trees. Ideally, these approaches would be inexpensive, abl...

Protective Effect of Ozone on Liver Ischemia–Reperfusion (I/R) Injury in Streptozotocin-Induced Diabetic Rats

The aim of this study was to investigate the effects of ozone therapy on the liver, one of the organs most affected by ischemia–reperfusion damage in people with diabetes. Thirty male Wistar albino rats were used in this study. The rats were randomly divided into four groups: the...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Integrated Pharmacokinetic Assessment and Individualized Dosing in Pediatric Critical Care

Optimizing pharmacotherapy in pediatric intensive care requires an integrated understanding of developmental physiology and critical illness-related pathophysiology. Drug exposure in children cannot be interpreted as a simple scaled version of adult pharmacokinetics. Critically i...

Machine-Learning Analysis of the Electronic Structure of Atomically Thin MnTe Films from Scanning Tunneling Spectroscopy

Layered two-dimensional (2D) van der Waals magnetic crystals based on 3d transition metals and chalcogenides are typically synthesized by chemical vapor transport, while establishing epitaxial, layer-by-layer growth under vacuum remains essential for device applications. Here, we...